CAJ | 학술논문

口腔癌是头颈部较常见的恶性肿瘤之一,被动靶向是口腔癌最初的靶向治疗,靶向性差.为了更好地实现对口腔癌靶向治疗,近年来学者们转向于研究主动靶向纳米给药系统,即将靶分子连接在纳米粒表面,使其与肿瘤细胞表面特异性表达或者过度表达的某种受体结合而实现靶向,该靶向系统可将抗肿瘤药物定向输送于病变部位,达到降低不良反应、增加疗效的目的.靶向性化疗已成为口腔癌治疗的趋势.
구강암시두경부교상견적악성종류지일,피동파향시구강암최초적파향치료,파향성차.위료경호지실현대구강암파향치료,근년래학자문전향우연구주동파향납미급약계통,즉장파분자련접재납미립표면,사기여종류세포표면특이성표체혹자과도표체적모충수체결합이실현파향,해파향계통가장항종류약물정향수송우병변부위,체도강저불량반응、증가료효적목적.파향성화료이성위구강암치료적추세.
Oral cancer is one of the most common malignant tumor of the head and neck.Passive targeting is a targeted therapy for initial treatment of oral cancer,which is not always effective.In order to achieve better targeted therapy on oral cancer,researchers have turned to the study of active targeting with nano drug delivery system in recent years.With this treatment,nanoparticles are attached to the surface of the target molecules,and combine with specific expression or overexpression receptor on the surface of tumor cell to achieve target.This delivery system can transport anticancer drugs directed at the lesion site and achieve the purpose of reducing adverse drug reaction and increasing treatment efficacy.Targeted chemotherapy is increasing being used in the treatment of oral cancer.