CAJ | 학술논문

研究证实异常表达的胃泌素与其受体结合后可激活相应的信号转导通路,促进大肠癌细胞增殖、抑制凋亡,而这一过程也与微小RNA(miRNA)的表达失调相关.研究表明,miRNA在大肠癌中的调控机制与胃泌素促大肠癌细胞增殖的信号通路存在多个交叉点,因此可能存在一条“胃泌素-miRNA-靶基因”信号转导通路.若能对该通路加以了解并对相关因素施以控制,将会为大肠癌的基因靶向治疗开辟一条新的途径.
연구증실이상표체적위비소여기수체결합후가격활상응적신호전도통로,촉진대장암세포증식、억제조망,이저일과정야여미소RNA(miRNA)적표체실조상관.연구표명,miRNA재대장암중적조공궤제여위비소촉대장암세포증식적신호통로존재다개교차점,인차가능존재일조“위비소-miRNA-파기인”신호전도통로.약능대해통로가이료해병대상관인소시이공제,장회위대장암적기인파향치료개벽일조신적도경.
It has been demonstrated that the combination of abnomal expression of gastrin with its receptor can promote cell proliferation and inhibit apoptosis in colorectal neoplasms via signal transduction pathways,which is related with the abnormal expression of miRNA.Researches show that there are multiple intersections between the molecule mechanisms of miRNA and the signaling pathway of gastrin in promoting colorectal cancer cell proliferation.It may exist a "gastrin-miRNA-target gene" signaling transduction pathway.Knowing the mechanism of the signaling pathway and controlling the related factors will open another avenue for the gene targeted therapy of colorectal neoplasms.