中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
33期
19-20
,共2页
银屑病%白细胞介素17%白细胞介素10
銀屑病%白細胞介素17%白細胞介素10
은설병%백세포개소17%백세포개소10
Psoriasis%Interleukin-17%Interleukin-10
目的 探讨银屑病与白细胞介素(IL)-17、IL-10表达的相关性.方法 采用酶联免疫吸附试验法检测32例银屑病患者(银屑病组)和30例健康体检者(对照组)血清IL-17和IL-10水平,并进行相关性分析.结果 银屑病组血清IL-17水平高于对照组[(57.59±11.99) ng/L比(33.27 ±6.49) ng/L],IL-10水平低于对照组[(25.38 ±4.32) ng/L比(32.01±5.54)n g/L],差异均有统计学意义(￡=9.84,5.27,P＜0.01).银屑病患者血清IL-17与IL-10呈负相关(r=-0.70,P＜0.01).结论 银屑病发病可能与IL-17、IL-10水平的失衡存在一定关联.
目的 探討銀屑病與白細胞介素(IL)-17、IL-10錶達的相關性.方法 採用酶聯免疫吸附試驗法檢測32例銀屑病患者(銀屑病組)和30例健康體檢者(對照組)血清IL-17和IL-10水平,併進行相關性分析.結果 銀屑病組血清IL-17水平高于對照組[(57.59±11.99) ng/L比(33.27 ±6.49) ng/L],IL-10水平低于對照組[(25.38 ±4.32) ng/L比(32.01±5.54)n g/L],差異均有統計學意義(￡=9.84,5.27,P＜0.01).銀屑病患者血清IL-17與IL-10呈負相關(r=-0.70,P＜0.01).結論 銀屑病髮病可能與IL-17、IL-10水平的失衡存在一定關聯.
목적 탐토은설병여백세포개소(IL)-17、IL-10표체적상관성.방법 채용매련면역흡부시험법검측32례은설병환자(은설병조)화30례건강체검자(대조조)혈청IL-17화IL-10수평,병진행상관성분석.결과 은설병조혈청IL-17수평고우대조조[(57.59±11.99) ng/L비(33.27 ±6.49) ng/L],IL-10수평저우대조조[(25.38 ±4.32) ng/L비(32.01±5.54)n g/L],차이균유통계학의의(￡=9.84,5.27,P＜0.01).은설병환자혈청IL-17여IL-10정부상관(r=-0.70,P＜0.01).결론 은설병발병가능여IL-17、IL-10수평적실형존재일정관련.
Objective To investigate the relationship between interleukin (IL)-17 and IL-10 in psoriasis.Methods The expression of IL-17 and IL-10 was measured by enzyme-linked immunosorbent assay in 32 patients with psoriasis (psoriasis group) and 30 normal controls (control group).The correlation of IL-17 and IL-10 was analyzed.Results The expression of IL-17 in psoriasis group was higher than that in control group[(57.59 ± 11.99) ng/L vs.(33.27 ± 6.49) ng/L] (t =9.84,P ＜ 0.01).The expression of IL-10 in psoriasis group was lower than that in control group [(25.38 ± 4.32) ng/L vs.(32.01 ± 5.54) ng/L] (t =5.27,P＜ 0.01).There was negative correlation between IL-17 and IL-10 in patients with psoriasis (r =-0.70,P ＜ 0.01).Conclusion The pathogenesis of psoriasis may be related to imbalance of IL-17 and IL-10.
