CAJ | 학술논문

目的分析低氟砖茶预防饮茶型氟中毒的干预效果.方法 2007-2010年,在内蒙古呼伦贝尔市嵯岗镇选择有饮茶习惯的35户蒙古族牧民家中常住人口为观察对象,采用无添加剂的低氟砖茶(含氟量为94.8 ～ 128.0 mg/kg),对牧民进行为期3年的干预试验,对比干预前与干预后牧民砖茶、奶茶、血、尿含氟量,经奶茶日摄氟量,X线氟骨症、骨密度及血液生物化学指标的改变,评价低氟砖茶干预饮茶型氟中毒效果.砖茶、奶茶含氟量及牧民血、尿含氟量测定采用离子选择电极法;氟斑牙诊断参照Dean法;临床氟骨症诊断参照《地方性氟骨症临床分度诊断》(GB 16396-1996);X线氟骨症诊断参照《氟骨症X线诊断》(WS 192-1999);骨密度诊断参照世界卫生组织骨质疏松诊断标准.结果干预前奶茶氟含量[(4.38±2.43) mg/L]高于干预后[(1.00±0.41)mg/L,t=6.56,P＜0.01];干预前血氟、尿氟含量[(0.068±0.018)、(3.17±1.97)mg/L]均高于干预后[(0.054±0.025)、(1.57±0.77)mg/L,t=3.24、5.78,P均＜0.01];干预前经奶茶摄氟量[(7.89±6.76)mg/d]高于干预后[(1.71±1.42)mg/d,t=7.62,P＜ 0.01].干预前与干预后X线氟骨症检出率均为32.79％(20/61),无新增病例;骨密度干预前(-0.74±1.18)低于干预后(-0.56±1.18,t=2.14,P＜0.05).血液生化检查,干预前胆固醇、低密度脂蛋白[(5.54±1.10)mmol/L、(3.28±0.68)mmol/L]均高于干预后[(4.67±0.95) mmol/L、(2.83±0.6)mmol/L,t=7.29、4.78,P均＜0.01];干预前尿素氮[(5.99±1.48) mmol/L]低于干预后[(5.45±1.42)mmol/L,t=2.24,P＜0.05].结论坚持饮用低氟砖茶可使牧民尿氟含量、经砖茶摄氟量明显降低,有预防饮茶型氟中毒的效果,并有降血脂作用,建议普遍推广.
목적 분석저불전다예방음다형불중독적간예효과.방법 2007-2010년,재내몽고호륜패이시차강진선택유음다습관적35호몽고족목민가중상주인구위관찰대상,채용무첨가제적저불전다(함불량위94.8 ～ 128.0 mg/kg),대목민진행위기3년적간예시험,대비간예전여간예후목민전다、내다、혈、뇨함불량,경내다일섭불량,X선불골증、골밀도급혈액생물화학지표적개변,평개저불전다간예음다형불중독효과.전다、내다함불량급목민혈、뇨함불량측정채용리자선택전겁법;불반아진단삼조Dean법;림상불골증진단삼조《지방성불골증림상분도진단》(GB 16396-1996);X선불골증진단삼조《불골증X선진단》(WS 192-1999);골밀도진단삼조세계위생조직골질소송진단표준.결과 간예전내다불함량[(4.38±2.43) mg/L]고우간예후[(1.00±0.41)mg/L,t=6.56,P＜0.01];간예전혈불、뇨불함량[(0.068±0.018)、(3.17±1.97)mg/L]균고우간예후[(0.054±0.025)、(1.57±0.77)mg/L,t=3.24、5.78,P균＜0.01];간예전경내다섭불량[(7.89±6.76)mg/d]고우간예후[(1.71±1.42)mg/d,t=7.62,P＜ 0.01].간예전여간예후X선불골증검출솔균위32.79％(20/61),무신증병례;골밀도간예전(-0.74±1.18)저우간예후(-0.56±1.18,t=2.14,P＜0.05).혈액생화검사,간예전담고순、저밀도지단백[(5.54±1.10)mmol/L、(3.28±0.68)mmol/L]균고우간예후[(4.67±0.95) mmol/L、(2.83±0.6)mmol/L,t=7.29、4.78,P균＜0.01];간예전뇨소담[(5.99±1.48) mmol/L]저우간예후[(5.45±1.42)mmol/L,t=2.24,P＜0.05].결론 견지음용저불전다가사목민뇨불함량、경전다섭불량명현강저,유예방음다형불중독적효과,병유강혈지작용,건의보편추엄.
Objective To analyze the effectiveness of low-fluoride brick tea on brick-tea-type fluorosis.Methods From 2007 to 2010,a 3-year-intervention trial,using low-fluoride brick tea without additives(fluorine content of 94.8-128.0 mg/kg),was carried out in Cuogang Township,Hulunbeier City of Inner Mongolia Autonomous Region,and resident from 35 Mongolia pastoralists households were involved in the trial.The followings were compared before and after the intervention trial:fluorine levels in brick tea,milk tea,blood,urine,daily fluoride intake through brick tea,the changes of X-ray,bone density and blood biochemistry indexes.Fluorine content in brick tea,milk tea,blood and urine was determined by ion selective electrode method; dental fluorosis was diagnosed by Dean method; clinical osteofluorosis was diagnosed using the reference of "Endemic Skeletal Fluorosis Diagnosis of Clinical Classification" (GB 16396-1996) ; X-ray skeletal fluorosis was diagnosed based on the reference of "Skeletal Fluorosis X-ray Diagnosis" (WS 192-1999); bone density was determined according to the reference standard of diagnosis of osteoporosis of WHO.Results Before the intervention trial fluorine content of tea[(4.38 ± 2.43)mg/L] was higher than that after the trial[(1.00 ± 0.41)mg/L,t =6.56,P ＜ 0.01] ; blood fluorine content in the population[(0.068 ± 0.018)mg/L] was higher than that after the trial[(0.054 ± 0.025)mg/L,t =3.24,P ＜ 0.01]; urinary fluoride content [(3.17 ± 1.97)mg/L] was higher than that after the trial [(1.57 ± 0.77)mg/L,t =5.78,P ＜ 0.01]; fluoride intake through milk tea [(7.89 ± 6.76)mg/d] was higher than that after the trial[(1.71 ± 1.42)mg/d,t =7.62,P ＜ 0.01].The skeletal fluorosis rate was 32.79％(20/61),no new patient was found after the trial; bone mineral density was improved,and the value before the trial(-0.74 ± 1.18) was lower than that after the trial(-0.56 ± 1.18,t =2.14,P ＜ 0.05).Blood biochemistry:cholesterol and low density lipoprotein before the trial[(5.54 ± 1.10),(3.28 ± 0.68)mmol/L] were higher than those after the trial [(4.67 ± 0.95),(2.83 ± 0.6)mmol/L,t =7.29,4.78,all P ＜ 0.01)]; blood urea nitrogen before the trial[(5.99 ± 1.48)mmol/L] was higher than that after the trial[(5.45 ± 1.42)mmol/L,t =2.24,P ＜ 0.05].Conclusions Drinking low-fluoride brick tea,can reduce the fluoride content in urine to normal level.The tea has a prevention effect on brick-tea-type fluorosis,which should be promoted.