中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2014年
11期
1342-1345
,共4页
刘影%安建斌%周娜磊%马景学%史俊芳%戴丽%任韬冉
劉影%安建斌%週娜磊%馬景學%史俊芳%戴麗%任韜冉
류영%안건빈%주나뢰%마경학%사준방%대려%임도염
频域光相干断层扫描%眼底荧光血管造影%Stargardt病
頻域光相榦斷層掃描%眼底熒光血管造影%Stargardt病
빈역광상간단층소묘%안저형광혈관조영%Stargardt병
Spectral-domain optical coherence tomography%Fundus fluorescence angiography%Stargardt's disease
目的 探讨频域光相干断层扫描(SD-OCT)联合眼底荧光血管造影(FFA)诊断Star-gardt病.方法 回顾性病例系列研究.对2008年1月至2013年12月在河北医大第二医院眼科就诊的21例(42只眼)Stargardt病的SD-OCT和FFA临床资料,分析总结其影像特征.结果 Stargardt病双眼病变对称,不同病变时期FFA和SD-OCT表现不同的特征.早期:眼底黄斑区污秽,色素紊乱,少量黄色斑点;FFA呈横椭圆形斑驳状透见荧光;SD-OCT黄斑区IS/OS层反射信号减弱或缺失,其余各层基本正常.中期:眼底黄斑区横椭圆形轻度萎缩灶,周围黄色斑点;FFA呈横椭圆形斑驳状透见荧光;SD-OCT黄斑区IS/OS层、外核层反射信号缺失,外丛状层塌陷,视网膜变薄;晚期:眼底黄斑区金箔样反光,横椭圆形萎缩灶,透见脉络膜大血管,周围大量黄色斑点;FFA呈“靶环”状透见荧光,周围斑点状透见荧光;SD-OCT黄斑区IS/OS层、外核层、外丛状层反射信号缺失,RPE层反射信号条带明显变薄,脉络膜反射信号明显增强,黄斑全层萎缩.结论 SD-OCT联合FFA可以明确诊断Star-gardt病,SD-OCT有助于评估病变的严重程度.
目的 探討頻域光相榦斷層掃描(SD-OCT)聯閤眼底熒光血管造影(FFA)診斷Star-gardt病.方法 迴顧性病例繫列研究.對2008年1月至2013年12月在河北醫大第二醫院眼科就診的21例(42隻眼)Stargardt病的SD-OCT和FFA臨床資料,分析總結其影像特徵.結果 Stargardt病雙眼病變對稱,不同病變時期FFA和SD-OCT錶現不同的特徵.早期:眼底黃斑區汙穢,色素紊亂,少量黃色斑點;FFA呈橫橢圓形斑駁狀透見熒光;SD-OCT黃斑區IS/OS層反射信號減弱或缺失,其餘各層基本正常.中期:眼底黃斑區橫橢圓形輕度萎縮竈,週圍黃色斑點;FFA呈橫橢圓形斑駁狀透見熒光;SD-OCT黃斑區IS/OS層、外覈層反射信號缺失,外叢狀層塌陷,視網膜變薄;晚期:眼底黃斑區金箔樣反光,橫橢圓形萎縮竈,透見脈絡膜大血管,週圍大量黃色斑點;FFA呈“靶環”狀透見熒光,週圍斑點狀透見熒光;SD-OCT黃斑區IS/OS層、外覈層、外叢狀層反射信號缺失,RPE層反射信號條帶明顯變薄,脈絡膜反射信號明顯增彊,黃斑全層萎縮.結論 SD-OCT聯閤FFA可以明確診斷Star-gardt病,SD-OCT有助于評估病變的嚴重程度.
목적 탐토빈역광상간단층소묘(SD-OCT)연합안저형광혈관조영(FFA)진단Star-gardt병.방법 회고성병례계렬연구.대2008년1월지2013년12월재하북의대제이의원안과취진적21례(42지안)Stargardt병적SD-OCT화FFA림상자료,분석총결기영상특정.결과 Stargardt병쌍안병변대칭,불동병변시기FFA화SD-OCT표현불동적특정.조기:안저황반구오예,색소문란,소량황색반점;FFA정횡타원형반박상투견형광;SD-OCT황반구IS/OS층반사신호감약혹결실,기여각층기본정상.중기:안저황반구횡타원형경도위축조,주위황색반점;FFA정횡타원형반박상투견형광;SD-OCT황반구IS/OS층、외핵층반사신호결실,외총상층탑함,시망막변박;만기:안저황반구금박양반광,횡타원형위축조,투견맥락막대혈관,주위대량황색반점;FFA정“파배”상투견형광,주위반점상투견형광;SD-OCT황반구IS/OS층、외핵층、외총상층반사신호결실,RPE층반사신호조대명현변박,맥락막반사신호명현증강,황반전층위축.결론 SD-OCT연합FFA가이명학진단Star-gardt병,SD-OCT유조우평고병변적엄중정도.
Objective To investigate the significance of combined SD-OCT and FFA in the diag nosis of Stargardt's disease.Methods Retrospective case series study.The SD-OCT and FFA images of 21 patients (42 eyes) with Stargardt's disease were collected and thereafter summarized the characteristics.Results The Stargardt's disease was known as bilateral ocular disorder with variable features at different stages.At the early stage,it presented as macula pigment disturbance and yellow flecks on biomicroscopy,mottled transmitted fluorescence on FFA,and the disruption and defect of IS/OS with normal choroidal appearance on SD-OCT.At the medium stage,Stargardt's disease was observed as mild oval-like atrophy lesion encircled by yellow dots by ophthalmoscope,mottled window defect at macula on FFA,and defect or absence of IS/OS,outer nuclear layer and outer plexiform layer signals on SD-OCT.While at the late stage,it was observed with golden reflection and oval atrophy lesion circled by yellow flecks by ophthalmoscope,target-like and dot-like window defect on FFA,and the disappearance of inner nuclear layer,outer plexiform layer and IS/OS layer,thinning of RPE layer and enhancement of choroid on SD-OCT,which indicated the atrophy of macular layers.Conclusions The combination of SD-OCT and FFA can diagnose Stargardt's disease precisely,and what's more,SD-OCT is of great importance in evaluating the severity of the disease.