CAJ | 학술논문

目的评估行玻璃体腔药物注射Avastin (bevacizumab,rhuMAb-VEGF)治疗的早产儿视网膜病变(retinopathy of Premature,ROP)病例的临床疗效.方法对2010年7月至2013年9月在广州市妇女儿童医疗中心眼科就诊的22例行玻璃体腔药物注射Avastin治疗的ROP患儿44只眼的临床治疗经过与疗效.所有患儿经筛查确诊后,在24 h内行玻璃体腔注射Avastin 0.03 ml/次,术后3～15 d行第一次复诊,随访8～21周,平均随访时间15周.结果 AP-ROP完全退化6例12只眼,病情控制2例4只眼.全身情况较差的典型ROP患儿完全退化4例8只眼,病情控制2例4只眼.阈值期ROP患儿完全退化4例8只眼,病情控制4例8只眼.结论对于AP-ROP患儿、典型ROP患儿,单独给予玻璃体腔注射Avastin,可多次给药,每次治疗期限不超过药物半衰期,能控制病情,基本不需要给予激光治疗.
목적 평고행파리체강약물주사Avastin (bevacizumab,rhuMAb-VEGF)치료적조산인시망막병변(retinopathy of Premature,ROP)병례적림상료효.방법 대2010년7월지2013년9월재엄주시부녀인동의료중심안과취진적22례행파리체강약물주사Avastin치료적ROP환인44지안적림상치료경과여료효.소유환인경사사학진후,재24 h내행파리체강주사Avastin 0.03 ml/차,술후3～15 d행제일차복진,수방8～21주,평균수방시간15주.결과 AP-ROP완전퇴화6례12지안,병정공제2례4지안.전신정황교차적전형ROP환인완전퇴화4례8지안,병정공제2례4지안.역치기ROP환인완전퇴화4례8지안,병정공제4례8지안.결론 대우AP-ROP환인、전형ROP환인,단독급여파리체강주사Avastin,가다차급약,매차치료기한불초과약물반쇠기,능공제병정,기본불수요급여격광치료.
Objective To study the clinical characteristics and outcome of the special cases of ROP after treated by intravitreal injections of Avastin.Methods A retrospective clinical analysis was performed on the data from 22 cases (44 eyes) of patients with ROP.All patients were treated within 24 hours by intravitreal injections with Avastin of 0.03 ml/eye/dose.Results In group of AP-ROP,6 cases (12 eyes) were stopped,2 cases (4 eyes) were controlled.In group of poor condition,4 cases (8 eyes) were stopped,2 cases (4 eyes) were controlled.In the group of threshold period ROP,4 cases (8 eyes) were stopped,4 cases (8 eyes) were controlled.Conclusions To the AP-ROP patients and typical ROP patients,treated by intravitreal injection can effectively control the development of the disease,in the time before and after 20 days (half-life period of Avastin),when growth disorder of new blood vessels appeared again.If give children Avastin injection again timely,most of patients won't appear large avascular and which needn't laser treatment.