中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2014年
11期
1494-1497
,共4页
受精,体外%受精%视网膜病,早产儿%发病率%回顾性研究
受精,體外%受精%視網膜病,早產兒%髮病率%迴顧性研究
수정,체외%수정%시망막병,조산인%발병솔%회고성연구
Fertilization in vitro%Fertilization%Retinopathy of prematurity%Incidence%Retrospective studies
目的 探讨自然受孕儿与试管婴儿的早产儿视网膜病变(ROP)发病率差异性及相关影响因素分析.方法 回顾性分析2008年1月至2012年4月间就诊于温州医科大学附属第二医院&育英儿童医院的早产儿共1 183例的临床资料,将其中1 058例自然受孕儿设为Ⅰ组,125例试管婴儿设为Ⅱ组,将ROP筛查结果记录,对两组ROP发病率差异性进行pear-son x2检验,将胎数、出生体质量、孕周、新生儿呼吸窘迫综合征、动脉导管未闭、新生儿高胆红素血症、颅内出血、新生儿窒息、先天性心脏病、新生儿贫血、新生儿败血症、支气管肺发育不良等疾病与ROP进行spearman相关性统计学分析.结果 Ⅰ组中ROP有138例,发病率为13.0％;Ⅱ组中ROP有17例,发病率为13.6％,两组ROP发病率差异无统计学意义(P＞0.05).以胎数、出生体质量、孕周分类,两组的ROP发病率差异无统计学意义(P＞0.05).出生体质量、孕周与ROP呈负相关(r=-0.13,-0.159,P＜0.05);胎数与ROP无关(P＞0.05);新生儿呼吸窘迫综合征与ROP呈正相关(r=0.096,P＜0.05);动脉导管未闭等疾病与ROP均无关(P＞0.05).结论 温州地区自然受孕儿与试管婴儿ROP发病率没有显著性差异.
目的 探討自然受孕兒與試管嬰兒的早產兒視網膜病變(ROP)髮病率差異性及相關影響因素分析.方法 迴顧性分析2008年1月至2012年4月間就診于溫州醫科大學附屬第二醫院&育英兒童醫院的早產兒共1 183例的臨床資料,將其中1 058例自然受孕兒設為Ⅰ組,125例試管嬰兒設為Ⅱ組,將ROP篩查結果記錄,對兩組ROP髮病率差異性進行pear-son x2檢驗,將胎數、齣生體質量、孕週、新生兒呼吸窘迫綜閤徵、動脈導管未閉、新生兒高膽紅素血癥、顱內齣血、新生兒窒息、先天性心髒病、新生兒貧血、新生兒敗血癥、支氣管肺髮育不良等疾病與ROP進行spearman相關性統計學分析.結果 Ⅰ組中ROP有138例,髮病率為13.0％;Ⅱ組中ROP有17例,髮病率為13.6％,兩組ROP髮病率差異無統計學意義(P＞0.05).以胎數、齣生體質量、孕週分類,兩組的ROP髮病率差異無統計學意義(P＞0.05).齣生體質量、孕週與ROP呈負相關(r=-0.13,-0.159,P＜0.05);胎數與ROP無關(P＞0.05);新生兒呼吸窘迫綜閤徵與ROP呈正相關(r=0.096,P＜0.05);動脈導管未閉等疾病與ROP均無關(P＞0.05).結論 溫州地區自然受孕兒與試管嬰兒ROP髮病率沒有顯著性差異.
목적 탐토자연수잉인여시관영인적조산인시망막병변(ROP)발병솔차이성급상관영향인소분석.방법 회고성분석2008년1월지2012년4월간취진우온주의과대학부속제이의원&육영인동의원적조산인공1 183례적림상자료,장기중1 058례자연수잉인설위Ⅰ조,125례시관영인설위Ⅱ조,장ROP사사결과기록,대량조ROP발병솔차이성진행pear-son x2검험,장태수、출생체질량、잉주、신생인호흡군박종합정、동맥도관미폐、신생인고담홍소혈증、로내출혈、신생인질식、선천성심장병、신생인빈혈、신생인패혈증、지기관폐발육불량등질병여ROP진행spearman상관성통계학분석.결과 Ⅰ조중ROP유138례,발병솔위13.0％;Ⅱ조중ROP유17례,발병솔위13.6％,량조ROP발병솔차이무통계학의의(P＞0.05).이태수、출생체질량、잉주분류,량조적ROP발병솔차이무통계학의의(P＞0.05).출생체질량、잉주여ROP정부상관(r=-0.13,-0.159,P＜0.05);태수여ROP무관(P＞0.05);신생인호흡군박종합정여ROP정정상관(r=0.096,P＜0.05);동맥도관미폐등질병여ROP균무관(P＞0.05).결론 온주지구자연수잉인여시관영인ROP발병솔몰유현저성차이.
Objective To investigate whether the incidence and severity of retinopathy of prematurity (ROP) differs between infants conceived naturally and those who were in vitro fertilization (IVF),and to analyze ROP-related factors,with a comparative case series.Methods This was a study on premature infants who required screening and treatment of ROP in the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University,carried out between January 2008 and April 2012.One thousand and one hundred eighty three infants met the study criteria and were divided into two groups:natural conception (group Ⅰ,1058 infants) and IVF (group Ⅱ,125 infants).Multiple variables were recorded,including birth weight (BW),gestational age (GA),number of births (NOB,singleton/twins/triplets),type of conception (natural conception/IVF),neonatal respiratory distress syndrome (NRDS),patent ductus arteriosus (PDA),neonatal asphyxia,neonatal hyperbilirubinemia (NHB),intracranial hemorrhage (IH),congenital heart disease (CHD),neonatal anemia,neonatal sepsis,and bronchopulmonary dysplasia (BPD).The results of ophthalmological examinations were also recorded.The incidence of ROP between groups was compared with the Pearson Chi-square test.We applied Spearman correlation analysis to identify the variables that were most significantly associated with ROP.Results There were 138 infants of ROP in group Ⅰ (total 1058,13.0％),and 17 in group Ⅱ (total 125,13.6％),without significant difference in the presence of ROP between two groups (P ＞ 0.05).No significant difference was found in the presence of ROP affected by BW,GA,NOB,NRDS and other diseases between two groups (P ＞ 0.05).A significantly inverse association was found between ROP and BW (P ＜ 0.05),and between ROP and GA (P ＜ 0.05).No association was found between ROP and NOB (P ＞ 0.05).There was no significant difference in the presence of diseases between infants conceived naturally and those by IVF in group ROP (P ＞ 0.05).A significant association was found between ROP and NRDS (P ＜ 0.05).No association was found between ROP and diseases (PDA,neonatal asphyxia,NHB,IH,CHD,neonatal anemia,neonatal sepsis,and BPD).Conclusions Our study shows that IVF was not a risk factor for ROP.
