CAJ | 학술논문

目的探讨利用MRI原始数据构建人正常离体胎盘动静脉血管网数字化三维模型的方法.方法收集6例孕妇足月分娩排出的离体胎盘,应用改良的自凝牙托材料对胎盘血管进行灌注,然后行增强T1高分辨率各向同性容积激发序列(T1e-THRIVE)的MRI扫描,将采集的原始数据导入Mimics 14.0软件中,行胎盘动静脉血管网三维重建,并与胎盘动静脉血管网铸型标本进行对比.结果 (1)MRI扫描在二维图像上可清晰呈现胎盘动静脉血管,利用MRI原始数据成功地构建出正常离体胎盘动静脉血管网数字化三维模型,三维模型真实、清晰地显示出胎盘动静脉各级血管,立体感强,并可提供图像大小的缩放、任意角度的旋转.(2)对胎盘动静脉血管网数字化三维模型进行结构分析显示,脐带中有1根脐静脉(第1级)及2根脐动脉(第1级),脐静脉在脐带根部开始往下分至5～7级,2根脐动脉在脐带根部吻合成血窦,再逐渐分级,末梢血管网分支丰富,终止于胎盘母体面.(3)将重建的胎盘动静脉血管网数字化三维模型与胎盘动静脉血管网铸型标本进行对比,结果显示,胎盘动静脉血管网数字化三维模型的血管网结构、形态、血管角度及走行方向,均与胎盘动静脉血管网铸型标本一致,两者的血管网形态相似性极高.结论利用MRI原始数据构建人正常离体胎盘动静脉血管网数字化三维模型是一种有效研究胎盘血管的新方法,其三维模型图像具有立体感强、血管光滑饱满、任意角度旋转且无辐射等优点,为临床在体胎盘血管的研究奠定了基础.
목적 탐토이용MRI원시수거구건인정상리체태반동정맥혈관망수자화삼유모형적방법.방법 수집6례잉부족월분면배출적리체태반,응용개량적자응아탁재료대태반혈관진행관주,연후행증강T1고분변솔각향동성용적격발서렬(T1e-THRIVE)적MRI소묘,장채집적원시수거도입Mimics 14.0연건중,행태반동정맥혈관망삼유중건,병여태반동정맥혈관망주형표본진행대비.결과 (1)MRI소묘재이유도상상가청석정현태반동정맥혈관,이용MRI원시수거성공지구건출정상리체태반동정맥혈관망수자화삼유모형,삼유모형진실、청석지현시출태반동정맥각급혈관,입체감강,병가제공도상대소적축방、임의각도적선전.(2)대태반동정맥혈관망수자화삼유모형진행결구분석현시,제대중유1근제정맥(제1급)급2근제동맥(제1급),제정맥재제대근부개시왕하분지5～7급,2근제동맥재제대근부문합성혈두,재축점분급,말소혈관망분지봉부,종지우태반모체면.(3)장중건적태반동정맥혈관망수자화삼유모형여태반동정맥혈관망주형표본진행대비,결과현시,태반동정맥혈관망수자화삼유모형적혈관망결구、형태、혈관각도급주행방향,균여태반동정맥혈관망주형표본일치,량자적혈관망형태상사성겁고.결론 이용MRI원시수거구건인정상리체태반동정맥혈관망수자화삼유모형시일충유효연구태반혈관적신방법,기삼유모형도상구유입체감강、혈관광활포만、임의각도선전차무복사등우점,위림상재체태반혈관적연구전정료기출.
Objective To investigate the reconstruction of digital three-dimensional (3D) model of normal human placental vascular network based on MRI data in vitro.Methods Six full term placentas were collected,casted with modified self-curing denture base resin and scanned by T1 e-THRIVE high resolution magnetic resonance imaging.MRI images were imported into Mimics 14.0 software for 3D reconstruction,and the 3D model was compared with placental vascular casting model.Results (1) The placental vascular network could be obtained on MR 2D images.The 3D model were reconstructed successfully,which showed clear,realistic images.The 3D model could be zoomed and revolved from any direction to observe the branches of arteries and veins.(2) The umbilical vein and 2 umbilical arteries could be seen in the 3D model.In the root of the umbilical cord,the umbilical vein divided into 5-7 branches.While the 2 umbilical arteries anatomoses to form blood sinus and then devided into sub-branches.All the peripheral vessels ended in chorionic plate with abundant sub-branches.(3) When compared with the casting of placental arterial-venous vascular network,the morphology,structure,angle and trend of vessels in 3D model was consistent with the casting network.Conclusions Reconstruction of digital 3D model of normal human placental vascular network based on MRI in vitro is a new and promising method for the study of placental vasculature.It has better vascular exposure,free rotation,radiation-free.It provides a promising base for the study of placental vasculature in vivo in the future.