CAJ | 학술논문

目的探讨MRI对常染色体隐性遗传性多囊肾病(ARPKD)胎儿的诊断价值.方法回顾性分析2005年7月至2013年12月间产前超声检查提示异常,然后行MR检查,并经引产后尸解或病理证实的ARPKD胎儿16例.MR扫描序列主要采用稳态自由进动(SSFP)序列、单次激发快速自旋回波(SSTSE)序列和快速加权序列T1WI.将产前MRI、超声表现与引产后尸解或病理结果进行对照分析.结果 16例ARPKD患儿均表现为双侧肾脏体积明显增大,SSTSE序列肾髓质弥漫性高信号小囊肿.11例合并羊水过少,11例合并双肺发育不良,6例合并肝纤维化.11例双肺发育不良和6例肝脏轻度纤维化超声均未提示,肾脏病变超声误诊1例,MRI诊断均正确.结论 MRI诊断胎儿ARPKD具有明显优势,不受羊水量的影响,能准确评价肾脏及肺异常.
목적 탐토MRI대상염색체은성유전성다낭신병(ARPKD)태인적진단개치.방법 회고성분석2005년7월지2013년12월간산전초성검사제시이상,연후행MR검사,병경인산후시해혹병리증실적ARPKD태인16례.MR소묘서렬주요채용은태자유진동(SSFP)서렬、단차격발쾌속자선회파(SSTSE)서렬화쾌속가권서렬T1WI.장산전MRI、초성표현여인산후시해혹병리결과진행대조분석.결과 16례ARPKD환인균표현위쌍측신장체적명현증대,SSTSE서렬신수질미만성고신호소낭종.11례합병양수과소,11례합병쌍폐발육불량,6례합병간섬유화.11례쌍폐발육불량화6례간장경도섬유화초성균미제시,신장병변초성오진1례,MRI진단균정학.결론 MRI진단태인ARPKD구유명현우세,불수양수량적영향,능준학평개신장급폐이상.
Objective To explore the value of MRI on fetal autosomal recessive polycystic kidney disease (ARPKD).Methods Sixteen pregnant women,aged from 28 to 38 years (average 30 years) and with gestation age from 22 to 36 weeks (average 25 weeks) underwent MR scanning with a 1.5 T MR unit within 24 to 48 hours after ultrasound examinations.The imaging sequences included steady-state free-precession (SSFP) sequence,single-shot turbo spin echo (SSTSE) sequence and T1-weighted fast imaging sequence.Prenatal US and MR imaging findings were compared with autopsy or pathological results.Results A total of 16 cases of ARPKD showed bilateral markedly enlarged kidneys and diffuse high signal small cysts in renal medulla on SSTSE sequence.Among the 16 cases,11 cases were with oligohydramnios,1 1 cases were with pulmonary hypoplasia,and 6 cases were with hepatic fibrosis.Eleven cases of pulmonary hypoplasia and 6 cases of hepatic fibrosis were all missed by US.For the diagnosis of the renal anomalies,US missed one case.MRI diagnosis was correct in all these cases.Conclusions MRI shows great advantages on the diagnosis of fetal ARPKD,and it is not affected by the amount of amniotic fluid.It can be used to evaluate kidney and lung abnormalities accurately.