中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2014年
12期
992-995
,共4页
祁佩红%史大鹏%李四保%郭希让
祁珮紅%史大鵬%李四保%郭希讓
기패홍%사대붕%리사보%곽희양
磁共振成像,弥散%视神经损伤%诱发电位,视觉
磁共振成像,瀰散%視神經損傷%誘髮電位,視覺
자공진성상,미산%시신경손상%유발전위,시각
Diffusion magnetic resonance imaging%Optic nerve injuries%Evoked potentials,visual
目的 探讨3.0 T MR扩散张量成像(DTI)对前部缺血性视神经病变(AION)的诊断价值.方法 2008年7月至2010年7月收集26例单侧亚急性AION患者行双侧视神经DTI和图形视觉诱发电位(P-VEP)检查,测量患侧与健侧视神经各向异性分数(FA)、ADC、垂直扩散率(λ1)、平行扩散率(λ//)值,以及P-VEP参数P100值和振幅A值.采用配对样本t检验比较患侧与健侧测量结果,并采用Pearson相关分析患侧视神经DTI参数与P-VEP参数之间的相关性.结果 患侧视神经FA、ADC、λ//λ⊥值分别为0.28±0.07、(1.43±0.20)×10-3mm2/s、(1.79±0.16)×10-3 mm2/s 、(1.25±0.17)×10-3 mm2/s,健侧视神经对应值分别为0.57±0.05、(1.04±0.17)×10-3 mm2/s、(1.71±0.19)×10-3mm2/s、(0.75±0.08)×10-3 mm2/s.与健侧视神经比较,患侧视神经FA值下降,ADC、λ//升高,差异具有统计学意义(t值分别为-19.269、10.537、15.301,P值均＜0.01),λ⊥值差异无统计学意义(t=1.632,P＞0.05).患侧眼与健侧眼P-VEP参数P100值分别为(132.7±17.5)、(94.9±9.1)ms,振幅A值分别为(4.53±1.70)、(9.66±2.52) μV,患侧眼P100值明显延长,振幅A值明显降低,与健侧眼比较差异均有统计学意义(t值分别为10.114、-9.300,P值均＜0.01).FA值和P-VEP的P100潜伏期呈负相关(r=-0.619,P＜0.01).患侧眼的ADC值、λ⊥值与P-VEP振幅A值呈明显负相关(r值分别为-0.722、-0.634,P值均＜0.01),FA值与P-VEP振幅A值呈正相关(r=0.539,P＜0.01).结论 DTI可以敏感地发现前部缺血性视神经的扩散障碍,可以作为缺血性视神经病变临床辅助评价手段.
目的 探討3.0 T MR擴散張量成像(DTI)對前部缺血性視神經病變(AION)的診斷價值.方法 2008年7月至2010年7月收集26例單側亞急性AION患者行雙側視神經DTI和圖形視覺誘髮電位(P-VEP)檢查,測量患側與健側視神經各嚮異性分數(FA)、ADC、垂直擴散率(λ1)、平行擴散率(λ//)值,以及P-VEP參數P100值和振幅A值.採用配對樣本t檢驗比較患側與健側測量結果,併採用Pearson相關分析患側視神經DTI參數與P-VEP參數之間的相關性.結果 患側視神經FA、ADC、λ//λ⊥值分彆為0.28±0.07、(1.43±0.20)×10-3mm2/s、(1.79±0.16)×10-3 mm2/s 、(1.25±0.17)×10-3 mm2/s,健側視神經對應值分彆為0.57±0.05、(1.04±0.17)×10-3 mm2/s、(1.71±0.19)×10-3mm2/s、(0.75±0.08)×10-3 mm2/s.與健側視神經比較,患側視神經FA值下降,ADC、λ//升高,差異具有統計學意義(t值分彆為-19.269、10.537、15.301,P值均＜0.01),λ⊥值差異無統計學意義(t=1.632,P＞0.05).患側眼與健側眼P-VEP參數P100值分彆為(132.7±17.5)、(94.9±9.1)ms,振幅A值分彆為(4.53±1.70)、(9.66±2.52) μV,患側眼P100值明顯延長,振幅A值明顯降低,與健側眼比較差異均有統計學意義(t值分彆為10.114、-9.300,P值均＜0.01).FA值和P-VEP的P100潛伏期呈負相關(r=-0.619,P＜0.01).患側眼的ADC值、λ⊥值與P-VEP振幅A值呈明顯負相關(r值分彆為-0.722、-0.634,P值均＜0.01),FA值與P-VEP振幅A值呈正相關(r=0.539,P＜0.01).結論 DTI可以敏感地髮現前部缺血性視神經的擴散障礙,可以作為缺血性視神經病變臨床輔助評價手段.
목적 탐토3.0 T MR확산장량성상(DTI)대전부결혈성시신경병변(AION)적진단개치.방법 2008년7월지2010년7월수집26례단측아급성AION환자행쌍측시신경DTI화도형시각유발전위(P-VEP)검사,측량환측여건측시신경각향이성분수(FA)、ADC、수직확산솔(λ1)、평행확산솔(λ//)치,이급P-VEP삼수P100치화진폭A치.채용배대양본t검험비교환측여건측측량결과,병채용Pearson상관분석환측시신경DTI삼수여P-VEP삼수지간적상관성.결과 환측시신경FA、ADC、λ//λ⊥치분별위0.28±0.07、(1.43±0.20)×10-3mm2/s、(1.79±0.16)×10-3 mm2/s 、(1.25±0.17)×10-3 mm2/s,건측시신경대응치분별위0.57±0.05、(1.04±0.17)×10-3 mm2/s、(1.71±0.19)×10-3mm2/s、(0.75±0.08)×10-3 mm2/s.여건측시신경비교,환측시신경FA치하강,ADC、λ//승고,차이구유통계학의의(t치분별위-19.269、10.537、15.301,P치균＜0.01),λ⊥치차이무통계학의의(t=1.632,P＞0.05).환측안여건측안P-VEP삼수P100치분별위(132.7±17.5)、(94.9±9.1)ms,진폭A치분별위(4.53±1.70)、(9.66±2.52) μV,환측안P100치명현연장,진폭A치명현강저,여건측안비교차이균유통계학의의(t치분별위10.114、-9.300,P치균＜0.01).FA치화P-VEP적P100잠복기정부상관(r=-0.619,P＜0.01).환측안적ADC치、λ⊥치여P-VEP진폭A치정명현부상관(r치분별위-0.722、-0.634,P치균＜0.01),FA치여P-VEP진폭A치정정상관(r=0.539,P＜0.01).결론 DTI가이민감지발현전부결혈성시신경적확산장애,가이작위결혈성시신경병변림상보조평개수단.
Objective To study the value of MR diffusion tensor imaging (MR-DTI)using a 3.0 T scanner in anterior ischemic optic neuropathy(AION).Methods A total of 26 patients suffering from unilateral subacute AION were examined using DTI and pattern visual evoked potential(P-VEP).The parameters values of optic nerves including fractional anisotropy (FA),ADC,vertical diffusivity (λ⊥),paralleldiffusion (λ//),P100 value and amplitude were obtained.Paired t-tests were used for comparing the FA,ADC,λ⊥,and λ// values of the two groups.Correlations of DTI parameters and P-VEP parameters were analysed by using the Pearson rank correlation analysis.Results The values of FA,ADC,λ//,and λ_ in the affected nerve were 0.28±0.07,(1.43±0.20) ×103 mm2/s,(1.79±0.16) ×10-3 mm2/s,and (1.25±0.17) ×10-3 mm2/s respectively,and the corresponding values of unaffected nerve were 0.57±0.05,(1.04±0.17) ×10-3 mm2/s,(1.71 ±0.19) × 10-3 mm2/s,and (0.75±0.08) × 10-3 mm2/s respectively.Compared to unaffected contralateral nerves,the mean FA was reduced,the mean ADC,λ⊥ were increased in the affected nerves(t=-19.269,10.537,15.301,P＜0.01).However,there were no significant difference of the λ//(t=l.632,P＞0.05).There was significant negative correlation between ADC and P-VEP amplitude in affected optic nerves (r=-0.722,P＜0.01).There was moderate negative correlation between λ⊥ and P-VEP amplitude in affected optic nerves (r=-0.634,P＜0.01).There was moderate correlation between FA and P-VEP amplitude (r=0.539,P＜0.01).There was no correlation between λ// and P-VEP amplitude.There was moderate negative correlation between FA and P-VEP P100 latency(r =-0.619,P＜0.01).Conclusions DTI can sensitively detect diffusional abnormality of anterior ischemic optic neuropathy.DTI could be used as a supplemental way in the assessment of AION.
