CAJ | 학술논문

目的用Meta分析方法综合评估长期天然高本底辐照对人群外周血染色体畸变率的影响.方法检索国内外相关中英文数据库文献,并按照事先定义的纳入和排除标准,剔除不符合要求的文献,对纳入文献采用Meta分析方法进行综合定量分析,对9篇有染色体畸变率的研究进行综合分析,其中,2篇为单独报道易位率,2篇为单独报道非稳定性畸变率,综合报道的5篇.高本底辐射组研究总人数17 777人,对照组总人数10 386人.用Stata 12.0进行分析,Q检验和I2检验反映异质性的大小,发表偏倚用漏斗图法、Begg秩相关和Egger线性回归法识别.结果长期居住于天然高本底辐射地区的居民外周血染色体易位率和非稳定性畸变(双着丝粒+环状染色体、断片)率高于对照地区,其OR和95％ CI分别为:1.57(1.10,2.24)和2.04(1.32,3.14);对易位率影响的研究中,男性、女性、成人和中国地区的OR和95％CI分别为1.24(1.09,1.42)、1.37(1.17,1.60)、1.17(1.05,1.30)、1.38(1.25,1.51),异质性检验I2分别为0.00、0.00、69.50％和0.00;对非稳定性畸变率影响的研究中,女性、成人、儿童、伊朗和中国地区的OR和95％ CI分别为3.78(2.40,5.97)、2.60(2.25,3.00)、1.03 (0.85,1.24)、3.19(2.46,4.13)和1.64(1.33,2.02),异质性检验I2分别为:0.00、69.60％、0.00、21.60％和0.00;高本底辐射、性别和年龄是上述异质性的来源.结论长期暴露于天然高本底辐射会增加外周血淋巴细胞染色体易位率和非稳定性畸变率,应综合分析其对高本底辐射暴露人群产生的健康风险,为建立防护措施和出台相关政策提供科学依据.
목적 용Meta분석방법종합평고장기천연고본저복조대인군외주혈염색체기변솔적영향.방법 검색국내외상관중영문수거고문헌,병안조사선정의적납입화배제표준,척제불부합요구적문헌,대납입문헌채용Meta분석방법진행종합정량분석,대9편유염색체기변솔적연구진행종합분석,기중,2편위단독보도역위솔,2편위단독보도비은정성기변솔,종합보도적5편.고본저복사조연구총인수17 777인,대조조총인수10 386인.용Stata 12.0진행분석,Q검험화I2검험반영이질성적대소,발표편의용루두도법、Begg질상관화Egger선성회귀법식별.결과 장기거주우천연고본저복사지구적거민외주혈염색체역위솔화비은정성기변(쌍착사립+배상염색체、단편)솔고우대조지구,기OR화95％ CI분별위:1.57(1.10,2.24)화2.04(1.32,3.14);대역위솔영향적연구중,남성、녀성、성인화중국지구적OR화95％CI분별위1.24(1.09,1.42)、1.37(1.17,1.60)、1.17(1.05,1.30)、1.38(1.25,1.51),이질성검험I2분별위0.00、0.00、69.50％화0.00;대비은정성기변솔영향적연구중,녀성、성인、인동、이랑화중국지구적OR화95％ CI분별위3.78(2.40,5.97)、2.60(2.25,3.00)、1.03 (0.85,1.24)、3.19(2.46,4.13)화1.64(1.33,2.02),이질성검험I2분별위:0.00、69.60％、0.00、21.60％화0.00;고본저복사、성별화년령시상술이질성적래원.결론 장기폭로우천연고본저복사회증가외주혈림파세포염색체역위솔화비은정성기변솔,응종합분석기대고본저복사폭로인군산생적건강풍험,위건립방호조시화출태상관정책제공과학의거.
Objective To quantitatively analyze the effects of high background radiation area (HBRA) on the frequencies of translocation and unstable chromosome aberrations in human peripheral blood lymphocytes.Methods Based on the data from 9 published articles retrieved from 7 electronic databases,the Meta-analysis was performed to evaluate the effects of high natural background radiation (HNBR) on the frequencies of chromosome aberrations in the peripheral blood lymphocytes in 17 777 persons from HBRA and 10 386 from the control area (CA).Cochrane's Q and I2 statistics were used to evaluate heterogeneity among studies and pooling odds ratio (OR) with 95％ confidence intervals (95％ CI) were calculated using random-effect models.Publication bias was also calculated by funnel plot,Egger linear regression test and Begg rank correlation test.Results The pooling OR of translocation [OR(95％ CI) =1.57(1.10-2.24)] and unstable chromosome aberration [OR(95％ CI) =2.04(1.32-3.14)] of long-term exposed inhabitants living in HBRA were higher than control.The subgroup analysis showed that,fortranslocation,the OR (95％ CI) were 1.24 (1.09-1.42,I2 =0.00) for male,1.37 (1.17-1.60,I2 =0.00) for female,1.17 (1.05-1.30,I2 =69.50％) for adults,and 1.38 (1.25-1.51,I2 =0.00) for Chinese.For unstable chromosome aberration,the OR (95％ CI) were 3.78 (2.40-5.97,I2 =0.00) for female,2.60 (2.25-3.00,I2 =69.60％) for adults,1.03(0.85-1.24,I2 =0.00) for children,3.19 (2.46-4.13,I2 =21.60％) for Iranian,and 1.64 (1.33-2.02,I2 =0.00) for Chinese.HBRA,age and sex differences were the reasons of above heterogeneity.Conclusions To the inhabitants living in HBRA,the frequencies of translocation and unstable chromosome aberration of peripheral blood lymphocytes are higher than those in control area.More comprehensive analysis should be performed to assess the health risk in HBRA inhabitants,which may arise new stragety in radiation protection.