CAJ | 학술논문

目的研究豚鼠Oddi括约肌运动功能在胆囊色素结石形成中的作用.方法 34只成年雄性Hartley豚鼠随机分为胆色素结石组和对照组.胆色素结石组(根据处死的时间分为4个亚组),给予致石饮食.3、6、9和12周后对两组行Oddi括约肌测压并检测肌电活动.结果胆色素结石的发生率分别为0、0、16.7％和66.7％(3周、6周、9周和12周).肌电活动的频率在3周组(P＜0.05)明显减小.肌电活动的幅度有缩小的趋势,但差异无统计学意义.Oddi括约肌收缩频率在9周组(P＜0.05)明显减小.Oddi括约肌基础压及胆总管压在12周组明显升高[(25 ±8)mmHg(1 mmHg =0.133 kPa)至(41±12) mmHg和(22 ±8)mmHg至(39±12) mmHg,P＜0.05].结论致胆色素结石饮食能够诱发Oddi括约肌功能紊乱.Oddi括约肌运动功能紊乱是胆色素结石形成的一个重要因素.
목적 연구돈서Oddi괄약기운동공능재담낭색소결석형성중적작용.방법 34지성년웅성Hartley돈서수궤분위담색소결석조화대조조.담색소결석조(근거처사적시간분위4개아조),급여치석음식.3、6、9화12주후대량조행Oddi괄약기측압병검측기전활동.결과 담색소결석적발생솔분별위0、0、16.7％화66.7％(3주、6주、9주화12주).기전활동적빈솔재3주조(P＜0.05)명현감소.기전활동적폭도유축소적추세,단차이무통계학의의.Oddi괄약기수축빈솔재9주조(P＜0.05)명현감소.Oddi괄약기기출압급담총관압재12주조명현승고[(25 ±8)mmHg(1 mmHg =0.133 kPa)지(41±12) mmHg화(22 ±8)mmHg지(39±12) mmHg,P＜0.05].결론 치담색소결석음식능구유발Oddi괄약기공능문란.Oddi괄약기운동공능문란시담색소결석형성적일개중요인소.
Objective To investigate the role of motility of Oddi's sphincter in pigment gallbladder stone formation in the model of guinea pigs.Methods Thirty-four general adult male Hartley guinea pigs were divided randomly into two groups.Control group (10 guinea pigs)and pigment stone groups (24 guinea pigs,which were divided into 4 subgroups with 6 guinea pigs each according to the time they were sacrificed),fed with pigment lithogenic diet.After 3,6,9 and 12 weeks later,Oddi's sphincter manometry and myoelectric activity record were obtained by multifunctional physiograph at each stage.Results The incidence of pigment gallstone formation was 0,0,16.7％ and 66.7％ in 3w,6w,9w and 12w group,respectively.The frequency of myoelectric activity decreased apparently in the 3w group(P ＜ 0.05).The amplitude of myoelectric activity had the tendency of decreasing but not statistically significant.The motility frequency of Oddi's sphincter decreased greatly in the 9w group (P ＜ 0.05).The basal pressure of Oddi's sphincter and common bile duct increased markedly in the 12w group [from (25 ± 8) mmHg (1 mmHg =0.133 kPa) to (41 ± 12) mmHg and from (22 ± 8) mmHg to (39 ± 12) mmHg,P ＜ 0.05)].Conclusions Pigment lithogenic diet may induce dysfunction of Oddi's sphincter.The disturbance of Oddi's sphincter motility may play a role in pigment gallstone formation.