CAJ | 학술논문

TGR5是一类胆汁酸膜受体,表达于多种组织细胞中,参与体内多种代谢和免疫疾病的发生.TGR5能够调节胆汁酸代谢,也参与血糖血脂代谢,减轻胰岛素抵抗,增加机体能量消耗,维持机体代谢稳定.在肝脏免疫中TGR5表达并调控单核细胞及Kupffer细胞.TGR5抑制Kupffer细胞炎症因子的表达和释放,调控树突状细胞的分化成熟,进而调控适应性免疫反应.本文主要讨论TGR5在肝脏代谢与免疫中的作用及其相关机制,揭示其在相关肝脏疾病中的临床意义.
TGR5시일류담즙산막수체,표체우다충조직세포중,삼여체내다충대사화면역질병적발생.TGR5능구조절담즙산대사,야삼여혈당혈지대사,감경이도소저항,증가궤체능량소모,유지궤체대사은정.재간장면역중TGR5표체병조공단핵세포급Kupffer세포.TGR5억제Kupffer세포염증인자적표체화석방,조공수돌상세포적분화성숙,진이조공괄응성면역반응.본문주요토론TGR5재간장대사여면역중적작용급기상관궤제,게시기재상관간장질병중적림상의의.
TGR5,expressing in many tissue cells,is a kind of bile acid membrane receptor and participates in a variety of metabolic and immune diseases.Activated TGR5 can keep the metabolism system in a steady state by mediating the metabolism of bile acid,lipid,and blood sugar,reducing insulin resistance and increasing the body's energy consumption; TGR5 could regulate the immune responses of mononuclear cell and Kupffer cell in the liver.For example,it can regulate the adaptive immune response by inhibiting the expression and release of inflammatory cytokines in Kupffer cells,and regulating the differentiation and maturation of dendritic cells.This review mainly focused on the function of TGR5 in liver metabolism and immune and further explored the related mechanism,as well as its clinical significance in related liver diseases.