中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
6期
359-363
,共5页
梁凤晶%肖湘%肖婷%肖朝勇%刘文%肖舟%柴学%邹冰%沈继英
樑鳳晶%肖湘%肖婷%肖朝勇%劉文%肖舟%柴學%鄒冰%瀋繼英
량봉정%초상%초정%초조용%류문%초주%시학%추빙%침계영
孤独性障碍%杏仁核%磁共振波谱学
孤獨性障礙%杏仁覈%磁共振波譜學
고독성장애%행인핵%자공진파보학
Autistic disorder%Amygdala%Magnetic resonance spectroscopy
目的 分析2～3岁孤独谱系障碍(autism spectrum disorder,ASD)儿童与发育障碍儿童杏仁核体积的差异,并对ASD儿童杏仁核体积与社会情绪功能之间的相关性进行研究.方法 对46例ASD儿童(ASD组)和39例年龄、性别、发育商与之匹配的发育障碍儿童(对照组)进行磁共振扫描,手工勾画杏仁核,比较两组杏仁核体积的差异,利用婴幼儿沟通及象征性行为发展量表(Communication and Symbolic Behavior Scales Developmental Profile,CSBS-DP)评估患儿的社会交流能力,分析杏仁核体积与临床症状的相关性.结果 与对照组相比,2～3岁ASD儿童双侧杏仁核体积明显增大[左侧:(0.83 ±0.15) cm3与(0.72±0.13) cm3,t=3.55,P=0.001;右侧:(0.86±0.15)cm3与(0.77±0.12) cm3,t =2.83,P=0.006];在控制年龄和发育商后,ASD组儿童左侧杏仁核体积与社交领域中的手势项目(r=-0.331,P=0.042)及象征性行为领域中的游戏技巧项目均呈负相关(r=-0.333,P=0.041).结论 2～3岁的ASD儿童存在杏仁核体积增大,可能与患儿的社会情绪功能受损有关.
目的 分析2～3歲孤獨譜繫障礙(autism spectrum disorder,ASD)兒童與髮育障礙兒童杏仁覈體積的差異,併對ASD兒童杏仁覈體積與社會情緒功能之間的相關性進行研究.方法 對46例ASD兒童(ASD組)和39例年齡、性彆、髮育商與之匹配的髮育障礙兒童(對照組)進行磁共振掃描,手工勾畫杏仁覈,比較兩組杏仁覈體積的差異,利用嬰幼兒溝通及象徵性行為髮展量錶(Communication and Symbolic Behavior Scales Developmental Profile,CSBS-DP)評估患兒的社會交流能力,分析杏仁覈體積與臨床癥狀的相關性.結果 與對照組相比,2～3歲ASD兒童雙側杏仁覈體積明顯增大[左側:(0.83 ±0.15) cm3與(0.72±0.13) cm3,t=3.55,P=0.001;右側:(0.86±0.15)cm3與(0.77±0.12) cm3,t =2.83,P=0.006];在控製年齡和髮育商後,ASD組兒童左側杏仁覈體積與社交領域中的手勢項目(r=-0.331,P=0.042)及象徵性行為領域中的遊戲技巧項目均呈負相關(r=-0.333,P=0.041).結論 2～3歲的ASD兒童存在杏仁覈體積增大,可能與患兒的社會情緒功能受損有關.
목적 분석2～3세고독보계장애(autism spectrum disorder,ASD)인동여발육장애인동행인핵체적적차이,병대ASD인동행인핵체적여사회정서공능지간적상관성진행연구.방법 대46례ASD인동(ASD조)화39례년령、성별、발육상여지필배적발육장애인동(대조조)진행자공진소묘,수공구화행인핵,비교량조행인핵체적적차이,이용영유인구통급상정성행위발전량표(Communication and Symbolic Behavior Scales Developmental Profile,CSBS-DP)평고환인적사회교류능력,분석행인핵체적여림상증상적상관성.결과 여대조조상비,2～3세ASD인동쌍측행인핵체적명현증대[좌측:(0.83 ±0.15) cm3여(0.72±0.13) cm3,t=3.55,P=0.001;우측:(0.86±0.15)cm3여(0.77±0.12) cm3,t =2.83,P=0.006];재공제년령화발육상후,ASD조인동좌측행인핵체적여사교영역중적수세항목(r=-0.331,P=0.042)급상정성행위영역중적유희기교항목균정부상관(r=-0.333,P=0.041).결론 2～3세적ASD인동존재행인핵체적증대,가능여환인적사회정서공능수손유관.
Objective To evaluate amygdala volumes in 2-to 3-year old children with autism spectrum disorder (ASD) in comparison with developmental disorder (DD),and to investigate the correlation between the differential changes of amygdala volume and socio-emotional function impairment.Methods Amygdala was manually traced in 46 ASD children and 39 age,sex and development quotient matched DD children using MRI for volume comparison.The correlation between differential changes of amygdala volume and socio-emotional function was assessed by the Communication and Symbolic Behavior Scales Developmental Profile (CSBS-DP) Infant-Toddler Checklist.Results Compared with DD,the volumes of bilateral amygdala were significantly larger in ASD (left:(0.83 ± 0.15) cm3 vs.(0.72 ± 0.13)cm3,t =3.55,P=0.001; right:(0.86±0.15) cm3 vs.(0.77 ±0.12) cm3,t =2.83,P=0.006).Mter age and development quotient were controlled,left amygdala size in children with ASD was significantly associated with gestures area (r =-0.331,P =0.042) and object use area (r =-0.333,P =0.041) in CSBS-DP Infant-Toddler Checklist.Conclusion The abnormal pattern of amygdala size present in 2-to 3-year-old children with ASD may be associated with their socio-emotional function impairment.
