中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2014年
12期
924-927
,共4页
樊春月%王艳艳%张莹%郎丽%邓小峰%程樱
樊春月%王豔豔%張瑩%郎麗%鄧小峰%程櫻
번춘월%왕염염%장형%랑려%산소봉%정앵
鼠神经生长因子%职业性手臂振动病
鼠神經生長因子%職業性手臂振動病
서신경생장인자%직업성수비진동병
Mouse nerve growth factor%,Occupational hand-arm vibration disease
目的 观察鼠神经生长因子(NGF)治疗职业性手臂振动病(HAVD)的效果.方法 采用随机对照临床试验的方法,将64例HAVD患者随机分为治疗组(32例)和对照组(32例),对照组给予丹参、小牛血去蛋白提取物改善循环,甲钴胺片及维生素B6营养神经治疗;治疗组在对照组治疗的基础上加用NGF 30 μg/d,肌内注射,4周为1个疗程,治疗2个疗程,每疗程间休息15d.结果 治疗后,两组患者的临床症状和体征(手麻、手痛和双手痛觉、触觉及振动觉减弱)、冷水复温试验(CWLT)、神经-肌电图(ENMG)均比治疗前有不同程度改善(P＜0.05),治疗组的改善与对照组比较更为显著(P＜0.05).结论 NGF可以显著改善手麻、手痛的症状和双手痛觉、触觉、振动觉减弱体征及改善CWLT、ENMG,对HAVD的治疗有较好的疗效且较为安全,对于HAVD患者,应早期发现,早期诊断.早期予NGF治疗,可改善患者预后.
目的 觀察鼠神經生長因子(NGF)治療職業性手臂振動病(HAVD)的效果.方法 採用隨機對照臨床試驗的方法,將64例HAVD患者隨機分為治療組(32例)和對照組(32例),對照組給予丹參、小牛血去蛋白提取物改善循環,甲鈷胺片及維生素B6營養神經治療;治療組在對照組治療的基礎上加用NGF 30 μg/d,肌內註射,4週為1箇療程,治療2箇療程,每療程間休息15d.結果 治療後,兩組患者的臨床癥狀和體徵(手痳、手痛和雙手痛覺、觸覺及振動覺減弱)、冷水複溫試驗(CWLT)、神經-肌電圖(ENMG)均比治療前有不同程度改善(P＜0.05),治療組的改善與對照組比較更為顯著(P＜0.05).結論 NGF可以顯著改善手痳、手痛的癥狀和雙手痛覺、觸覺、振動覺減弱體徵及改善CWLT、ENMG,對HAVD的治療有較好的療效且較為安全,對于HAVD患者,應早期髮現,早期診斷.早期予NGF治療,可改善患者預後.
목적 관찰서신경생장인자(NGF)치료직업성수비진동병(HAVD)적효과.방법 채용수궤대조림상시험적방법,장64례HAVD환자수궤분위치료조(32례)화대조조(32례),대조조급여단삼、소우혈거단백제취물개선순배,갑고알편급유생소B6영양신경치료;치료조재대조조치료적기출상가용NGF 30 μg/d,기내주사,4주위1개료정,치료2개료정,매료정간휴식15d.결과 치료후,량조환자적림상증상화체정(수마、수통화쌍수통각、촉각급진동각감약)、랭수복온시험(CWLT)、신경-기전도(ENMG)균비치료전유불동정도개선(P＜0.05),치료조적개선여대조조비교경위현저(P＜0.05).결론 NGF가이현저개선수마、수통적증상화쌍수통각、촉각、진동각감약체정급개선CWLT、ENMG,대HAVD적치료유교호적료효차교위안전,대우HAVD환자,응조기발현,조기진단.조기여NGF치료,가개선환자예후.
Objective To investigate the efficacy of mouse nerve growth factor (mNGF) in treating occupational hand-arm vibration disease (HAVD).Methods Sixty-four patients with HAVD were equally and randomly divided into treatment group and control group.The control group was given Salvia miltiorrhiza Bunge and deproteinized extract of calf blood to improve circulation,and also given methylcobalamin tablets and vitamin B6 for neurotrophic treatment.In addition to the above treatments for the control group,the treatment group was also given 30 μg/d mNGF by intramuscular injection for two courses (4 weeks for each course) with a 15-day interval.Results Both the treatment group and the control group showed significant improvements in clinical symptoms and signs (hand numbness and pain,and reduced senses of touch,pain,and vibration),cold water loading test (CWLT),and electroneuromyography (ENMG) after treatments (P＜0.05).And the treatment group had significantly more improvements than the control group (P＜0.05).Conclusion mNGF can significantly improve hand numbness and pain,reduced senses of touch,pain,and vibration,CWLT,and ENMG,so it has better clinical effect and safety in treating HAVD.Early diagnosis and treatment can improve the outcome of patients with HAVD.
