CAJ | 학술논문

目的评价伐尼克兰在临床实践中对戒烟门诊患者戒烟的有效性.方法采用前瞻性观察性研究设计,选择符合纳入标准的吸烟者799人,每名患者首诊时进行标准的基线问卷评估,并在第1、第3和第6个月进行随访.由经过培训的医师对每名患者完成面对面的咨询和个体化戒烟干预.接受药物辅助戒烟者定为心理干预联合药物组(n=272),未用药者为单纯心理干预组(n=527).采用意向性分析的统计学方法分析比较两组的7天时点戒烟率、3个月随访时的1个月持续戒烟率和6个月随访时的3个月持续戒烟率.结果 6个月随访时,心理干预联合药物组的7天时点戒烟率显著高于单纯心理干预组(34.6％vs.23.1％;OR=1.75,95％ CI:1.27 ～ 2.42;P＜0.001),心理干预联合药物组的3个月持续戒烟率也显著高于单纯心理干预组(31.3％vs.18.2％; OR=2.04,95％CI:1.46 ～ 2.86;P＜0.001).1和3个月随访时,心理干预联合药物组无论是7天时点戒烟率还是1个月持续戒烟率均高于单纯心理干预组.结论在真实临床实践的戒烟门诊中,给予戒烟者药物辅助戒烟可有效提高戒烟率.
목적 평개벌니극란재림상실천중대계연문진환자계연적유효성.방법 채용전첨성관찰성연구설계,선택부합납입표준적흡연자799인,매명환자수진시진행표준적기선문권평고,병재제1、제3화제6개월진행수방.유경과배훈적의사대매명환자완성면대면적자순화개체화계연간예.접수약물보조계연자정위심리간예연합약물조(n=272),미용약자위단순심리간예조(n=527).채용의향성분석적통계학방법분석비교량조적7천시점계연솔、3개월수방시적1개월지속계연솔화6개월수방시적3개월지속계연솔.결과 6개월수방시,심리간예연합약물조적7천시점계연솔현저고우단순심리간예조(34.6％vs.23.1％;OR=1.75,95％ CI:1.27 ～ 2.42;P＜0.001),심리간예연합약물조적3개월지속계연솔야현저고우단순심리간예조(31.3％vs.18.2％; OR=2.04,95％CI:1.46 ～ 2.86;P＜0.001).1화3개월수방시,심리간예연합약물조무론시7천시점계연솔환시1개월지속계연솔균고우단순심리간예조.결론 재진실림상실천적계연문진중,급여계연자약물보조계연가유효제고계연솔.
Objective To evaluate the effectiveness of Varenicline for smoking cessation in a community-based smoking-cessation-clinic (SCC) in Chinese smokers.Methods A prospective observational study was conducted in Beijing,China.799 smokers (762 men and 37 women) were assessed on data gathered from structured questionnaires at baseline and follow up programs at 1,3 and 6 months.Trained physician counselors provided free individual counseling and follow-up interviews with brief counseling for all the subjects.272 subjects were additionally prescribed Varenicline according to their own choice and reported data were compared to those without Varenicline.Outcomes were self-reported,regarding the 7-day point prevalence on abstinence rate and continuous abstinence rates at 1,3 and 6 month follow-up periods.Results At 6-month and by intention-to-treat,the 7-day point prevalence on abstinence rate with Varenicline and counseling,was significantly higher than the group with counseling only (34.6％ versus 23.1％ ; OR=1.75,95％ CI:1.27-2.42; P＜0.001).The 3-month continuous abstinence rate at 6 month was higher in the group with Varenicline (31.3％ versus 18.2％ ; OR=2.04,95％ CI:1.46-2.86; P＜0.001).Varenicline also showed better outcomes at 1 and 3 month follow-up.Conclusion Varenicline prescription in the smoking cessation clinic appeared to be effective that doubled the rates of quitting among Chinese smokers in the practice at a community-based SCC.