中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2014年
12期
1392-1395
,共4页
戴丐国%伍登海%连建安%马红梅%姜斌华
戴丐國%伍登海%連建安%馬紅梅%薑斌華
대개국%오등해%련건안%마홍매%강빈화
微生态制剂%肝性脑病%肠内营养%肠黏膜屏障
微生態製劑%肝性腦病%腸內營養%腸黏膜屏障
미생태제제%간성뇌병%장내영양%장점막병장
Probiotics%Hepatic encephalopathy%Enteral nutrition%Intestinal mucosal barrier
目的 观察微生态制剂联合肠内营养治疗对肝性脑病患者血清内毒素、肿瘤坏死因子α(TNF-α)、白细胞介素18(IL-18)、血氨水平及全身营养状态的影响.方法 选取60例肝性脑病患者,在常规保肝利尿等治疗基础上,随机分为3组分别给予口服培菲康加肠内营养、单纯口服培菲康、单纯静脉营养治疗,疗程均为2周.分别检测治疗前后第7天、第14天血清内毒素、TNF-α、IL-18、血氨及白蛋白水平.结果 与治疗前相比,培菲康联合肠内营养治疗能明显降低血清内毒素、TNF-α、IL-18及血氨水平,明显升高血浆白蛋白,与单用培菲康和单用静脉营养治疗相比差异有统计学意义(P＜0.05).结论 微生态制剂联合肠内营养治疗能有效清除肝性脑病患者血氨、降低内毒素血症、保护肠黏膜屏障及改善机体的营养状态,是临床治疗肝性脑病安全有效方法.
目的 觀察微生態製劑聯閤腸內營養治療對肝性腦病患者血清內毒素、腫瘤壞死因子α(TNF-α)、白細胞介素18(IL-18)、血氨水平及全身營養狀態的影響.方法 選取60例肝性腦病患者,在常規保肝利尿等治療基礎上,隨機分為3組分彆給予口服培菲康加腸內營養、單純口服培菲康、單純靜脈營養治療,療程均為2週.分彆檢測治療前後第7天、第14天血清內毒素、TNF-α、IL-18、血氨及白蛋白水平.結果 與治療前相比,培菲康聯閤腸內營養治療能明顯降低血清內毒素、TNF-α、IL-18及血氨水平,明顯升高血漿白蛋白,與單用培菲康和單用靜脈營養治療相比差異有統計學意義(P＜0.05).結論 微生態製劑聯閤腸內營養治療能有效清除肝性腦病患者血氨、降低內毒素血癥、保護腸黏膜屏障及改善機體的營養狀態,是臨床治療肝性腦病安全有效方法.
목적 관찰미생태제제연합장내영양치료대간성뇌병환자혈청내독소、종류배사인자α(TNF-α)、백세포개소18(IL-18)、혈안수평급전신영양상태적영향.방법 선취60례간성뇌병환자,재상규보간이뇨등치료기출상,수궤분위3조분별급여구복배비강가장내영양、단순구복배비강、단순정맥영양치료,료정균위2주.분별검측치료전후제7천、제14천혈청내독소、TNF-α、IL-18、혈안급백단백수평.결과 여치료전상비,배비강연합장내영양치료능명현강저혈청내독소、TNF-α、IL-18급혈안수평,명현승고혈장백단백,여단용배비강화단용정맥영양치료상비차이유통계학의의(P＜0.05).결론 미생태제제연합장내영양치료능유효청제간성뇌병환자혈안、강저내독소혈증、보호장점막병장급개선궤체적영양상태,시림상치료간성뇌병안전유효방법.
Objective To evaluate the effect of microecologic treatment combined enteral nutrition on serum endotoxin,tumor necrosis factor-α (TNF-α),interleukin-18 (IL-18),blood ammonia levels and nutritional status in patients with hepatic encephalopathy.Methods 60 patients with hepatic encephalopathy were allocted randomly into 3 groups,on the basis of conventional liver protective therapy and uragogue with one group given probiotics plus enteral nutrition,one given probiotics only,and the 3rd group given intravenous nutrition.The whole course of treatment was four weeks.Serum levels of endotoxin,TNF-α,IL-18,ammonia and albumin were determined before and on the 7th and 14th day after treatment.Results The levels of serum endotoxin,TNF-α,IL-18 and blood ammonia in the combined treatment group decreased remarkably after treatment,while the level of serum albumin elevated markedly.The difference was significant at statistics as compared with the only probiotics group and intravenous nutrition group (P＜0.05).Conclusion Microecologic treatment combined enteral nutrition could effectively reduce blood ammonia and serum endotoxin levels,protect intestinal mucosal barrier,as well as improve nutritional status of patients with hepatic encephalopathy,which was considered as a safe and efficient therapy.
