中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
46期
3652-3654
,共3页
李一雷%王颖%刘新媛%郭昊%王征%翟宁%李久宏
李一雷%王穎%劉新媛%郭昊%王徵%翟寧%李久宏
리일뢰%왕영%류신원%곽호%왕정%적저%리구굉
银屑病%血管内皮生长因子类%免疫组织化学%酶联免疫吸附试验
銀屑病%血管內皮生長因子類%免疫組織化學%酶聯免疫吸附試驗
은설병%혈관내피생장인자류%면역조직화학%매련면역흡부시험
Psoriasis%Vascular endothelial growth factors%Immunohistochemistory%Enzyme-linked immunosorbent assay
目的 探讨血管内皮生长因子(VEGF)与银屑病发病的关系.方法 选取2011年12月至2013年5月中国医科大学附属第一医院皮肤科诊断的寻常型银屑病患者,采用免疫组化法检测34例银屑病患者皮损和21例正常皮肤标本中VEGF的表达情况;采用酶联免疫吸附法(ELISA)检测70例寻常性银屑病患者和39名健康人血清中VEGF的表达.结果 银屑病患者皮损VEGF表达阳性率高于对照组(x2=13.34,P＜0.01);银屑病患者血清中VEGF表达亦明显高于对照组[(501±13)比(413±5)ng/L,t =2.32,P＜0.01].银屑病面积与严重性指数(PASI)评分＞10分的患者血清VEGF水平显著高于PASI评分≤10分的患者[(530±18)比(451±8) ng/L,t =2.18,P＜0.01].结论 银屑病患者VEGF水平的变化可能与其发病有关.
目的 探討血管內皮生長因子(VEGF)與銀屑病髮病的關繫.方法 選取2011年12月至2013年5月中國醫科大學附屬第一醫院皮膚科診斷的尋常型銀屑病患者,採用免疫組化法檢測34例銀屑病患者皮損和21例正常皮膚標本中VEGF的錶達情況;採用酶聯免疫吸附法(ELISA)檢測70例尋常性銀屑病患者和39名健康人血清中VEGF的錶達.結果 銀屑病患者皮損VEGF錶達暘性率高于對照組(x2=13.34,P＜0.01);銀屑病患者血清中VEGF錶達亦明顯高于對照組[(501±13)比(413±5)ng/L,t =2.32,P＜0.01].銀屑病麵積與嚴重性指數(PASI)評分＞10分的患者血清VEGF水平顯著高于PASI評分≤10分的患者[(530±18)比(451±8) ng/L,t =2.18,P＜0.01].結論 銀屑病患者VEGF水平的變化可能與其髮病有關.
목적 탐토혈관내피생장인자(VEGF)여은설병발병적관계.방법 선취2011년12월지2013년5월중국의과대학부속제일의원피부과진단적심상형은설병환자,채용면역조화법검측34례은설병환자피손화21례정상피부표본중VEGF적표체정황;채용매련면역흡부법(ELISA)검측70례심상성은설병환자화39명건강인혈청중VEGF적표체.결과 은설병환자피손VEGF표체양성솔고우대조조(x2=13.34,P＜0.01);은설병환자혈청중VEGF표체역명현고우대조조[(501±13)비(413±5)ng/L,t =2.32,P＜0.01].은설병면적여엄중성지수(PASI)평분＞10분적환자혈청VEGF수평현저고우PASI평분≤10분적환자[(530±18)비(451±8) ng/L,t =2.18,P＜0.01].결론 은설병환자VEGF수평적변화가능여기발병유관.
Objective To explore the relationship between vascular endothelial growth factor (VEGF) and the onset of psoriasis.Methods The intensity and site expression of VEGF in 34 psoriatic lesions and skin samples of 21 normal controls were observed by immunohistochemistory from December 2011to May 2013.And the serum levels of VEGF in 70 psoriasis vulgaris and 39 normal controls were measured by enzyme-linked immunosorbent assay (ELISA).Results The expression of VEGF in psoriatic lesions was much higher than that in normal controls(x2 =13.34,P ＜ 0.01).The serum level of VEGF in psoriasis vulgaris was higher than that in normal controls ((501 ± 13) vs (413 ± 5) ng/L,t =2.32,P ＜ 0.01).The serum level of VEGF in psoriasis vulgaris with PASI score ＞ 10 was higher than that with PASI score ≤ 10((530±18)vs(451 ± 8) ng/L,t =2.18,P ＜0.01).Conclusion VEGF may play a role in the pathogenesis of psoriasis.
