中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
12期
1749-1751
,共3页
肺疾病,慢性阻塞性%呼吸功能不全%支气管舒张药物
肺疾病,慢性阻塞性%呼吸功能不全%支氣管舒張藥物
폐질병,만성조새성%호흡공능불전%지기관서장약물
Pulmonary disease,chronic obstructive%Respiratory insufficiency%Bronchodilators%Treatment outcome%Adverse drug actions
目的 探讨支气管舒张药物联合用于治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的疗效及安全性.方法 将深圳市龙岗区第三人民医院于2012年3月至2014年3月收治的62例COPD合并呼吸衰竭患者按Doll's随机数字表法分为观察组和对照组,各31例.对照组给予持续吸氧和内科药物治疗等常规治疗,观察组在对照组基础上联合使用硫酸沙丁胺醇气雾剂和异丙托溴铵气雾剂治疗.比较2组患者治疗效果、血气分析指标、住院时间及不良反应发生率.结果 观察组有效率[96.8％ (30/31)]高于对照组[83.9％(26/31)],差异有统计学意义(P =0.038).治疗后,观察组氧分压[(70±6)mmHg(1 mmHg =0.133 kPa)]高于治疗前[(48 ±6)mmHg]和对照组同时间[(60±10)mmHg],二氧化碳分压[(42±5)mmHg]低于治疗前[(64 ±8)mmHg]和对照组同时间[(46±7)mmHg],差异均有统计学意义(均P＜0.05).对照组平均住院时间长于观察组[(18.7±3.0)d比(15.1±1.8)d],差异有统计学意义(P＜0.05).对照组与观察组的不良反应发生率比较[16.1％ (5/31)比25.8％ (8/31)],差异无统计学意义(P＞0.05).结论 支气管舒张药物联合应用可明显改善COPD合并呼吸衰竭患者的临床症状和血气参数,有效缩短患者的住院时间.
目的 探討支氣管舒張藥物聯閤用于治療慢性阻塞性肺疾病(COPD)閤併呼吸衰竭的療效及安全性.方法 將深圳市龍崗區第三人民醫院于2012年3月至2014年3月收治的62例COPD閤併呼吸衰竭患者按Doll's隨機數字錶法分為觀察組和對照組,各31例.對照組給予持續吸氧和內科藥物治療等常規治療,觀察組在對照組基礎上聯閤使用硫痠沙丁胺醇氣霧劑和異丙託溴銨氣霧劑治療.比較2組患者治療效果、血氣分析指標、住院時間及不良反應髮生率.結果 觀察組有效率[96.8％ (30/31)]高于對照組[83.9％(26/31)],差異有統計學意義(P =0.038).治療後,觀察組氧分壓[(70±6)mmHg(1 mmHg =0.133 kPa)]高于治療前[(48 ±6)mmHg]和對照組同時間[(60±10)mmHg],二氧化碳分壓[(42±5)mmHg]低于治療前[(64 ±8)mmHg]和對照組同時間[(46±7)mmHg],差異均有統計學意義(均P＜0.05).對照組平均住院時間長于觀察組[(18.7±3.0)d比(15.1±1.8)d],差異有統計學意義(P＜0.05).對照組與觀察組的不良反應髮生率比較[16.1％ (5/31)比25.8％ (8/31)],差異無統計學意義(P＞0.05).結論 支氣管舒張藥物聯閤應用可明顯改善COPD閤併呼吸衰竭患者的臨床癥狀和血氣參數,有效縮短患者的住院時間.
목적 탐토지기관서장약물연합용우치료만성조새성폐질병(COPD)합병호흡쇠갈적료효급안전성.방법 장심수시룡강구제삼인민의원우2012년3월지2014년3월수치적62례COPD합병호흡쇠갈환자안Doll's수궤수자표법분위관찰조화대조조,각31례.대조조급여지속흡양화내과약물치료등상규치료,관찰조재대조조기출상연합사용류산사정알순기무제화이병탁추안기무제치료.비교2조환자치료효과、혈기분석지표、주원시간급불량반응발생솔.결과 관찰조유효솔[96.8％ (30/31)]고우대조조[83.9％(26/31)],차이유통계학의의(P =0.038).치료후,관찰조양분압[(70±6)mmHg(1 mmHg =0.133 kPa)]고우치료전[(48 ±6)mmHg]화대조조동시간[(60±10)mmHg],이양화탄분압[(42±5)mmHg]저우치료전[(64 ±8)mmHg]화대조조동시간[(46±7)mmHg],차이균유통계학의의(균P＜0.05).대조조평균주원시간장우관찰조[(18.7±3.0)d비(15.1±1.8)d],차이유통계학의의(P＜0.05).대조조여관찰조적불량반응발생솔비교[16.1％ (5/31)비25.8％ (8/31)],차이무통계학의의(P＞0.05).결론 지기관서장약물연합응용가명현개선COPD합병호흡쇠갈환자적림상증상화혈기삼수,유효축단환자적주원시간.
Objective To explore the therapeutic effect and security of multiple bronchodilators treating chronic obstructive pulmonary diseases(COPD) complicated with respiratory failure.Methods Sixty-two cases of COPD with respiratory failure were divided into two groups according to the Doll's random number table method.31 cases were in control group and had conventional therapy,including persistent oxygen inspiration and drug treatment.Other 31 cases were in observer group and had multiple bronchodilators on the basis of conventional therapy.The changes of clinical symptoms,parameters of blood gas,adverse drug actions and hospital stays were compared.Results The effective rate of observation group [96.8％ (30/31)] was higher than that of the control group [83.9％ (26/31)],the difference was statistically significant (P =0.038).After treatment,the oxygen tension of observation group [(70 ±6)mmHg] was higher than that of the control group[(60 ± 10)mmHg],the partial pressure of carbon dioxide of observation group [(42 ± 5) mmHg] was lower than that of the control group [(46 ± 7) mmHg],the difference were statistically significant differences(all P ＜ 0.05).The average stay of the control group was longer than that of the observation group[(18.71 ± 3.0) d vs (15.1 ± 1.8) d],the difference was statistically significant(P ＜ 0.05).The differences of incidence of adverse reaction of the control group and observation group showed no significance [16.1％ (5/31) vs 16.1％ (8/31),P ＞ 0.05].Conclusion The combined application of bronchodilator can obviously improve the clinlcal symptom,decrease the time in hospital,has better curative effect of the COPD patients complicated with respiratory failure.
