中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
12期
1775-1779
,共5页
帕瑞昔布钠%腹腔镜%苏醒期躁动%Meta分析
帕瑞昔佈鈉%腹腔鏡%囌醒期躁動%Meta分析
파서석포납%복강경%소성기조동%Meta분석
Parecoxib Na%Laparoscopes%Emergence agitation%Meta-analysis
目的 系统分析帕瑞昔布钠预防成人腹腔镜手术麻醉苏醒期躁动的有效性和安全性,为临床合理用药提供参考.方法 通过检索PubMed、EBSCO、Springer、Ovid、EMbase、Cochrane Library、Web of Science 和中国期刊全文数据库、维普中文科技期刊数据库、万方数据库,查找帕瑞昔布钠预防成人腹腔镜手术麻醉苏醒期躁动的随机对照试验.对符合纳入标准的文献进行质量评价和资料提取,采用RevMan 5.2.7软件对苏醒期躁动的发生率及恶心呕吐等进行Meta分析.结果 最终纳入文献9篇,共计患者580例.其中帕瑞昔布钠组(在麻醉前、麻醉中或麻醉后给予帕瑞昔布钠)300例,对照组(在麻醉前、麻醉中或麻醉后给予0.9％氯化钠注射液)280例.Meta分析结果显示,与对照组相比,帕瑞昔布钠组腹腔镜手术麻醉苏醒期躁动发生率更低[相对危险度(RR)=0.23,95％置信区间:0.15 ～ 0.34],苏醒期躁动评分更低(加权均数差=-0.85,95％置信区间:-1.12～-0.57),术后恶心呕吐发生率更低(RR=0.34,95％置信区间:0.15～0.78),镇痛需求更少(RR=0.09,95％置信区间:0.02 ～0.44).结论 本研究表明帕瑞昔布钠超前镇痛,能有效预防成人腹腔镜手术麻醉苏醒期躁动,且安全性较高.
目的 繫統分析帕瑞昔佈鈉預防成人腹腔鏡手術痳醉囌醒期躁動的有效性和安全性,為臨床閤理用藥提供參攷.方法 通過檢索PubMed、EBSCO、Springer、Ovid、EMbase、Cochrane Library、Web of Science 和中國期刊全文數據庫、維普中文科技期刊數據庫、萬方數據庫,查找帕瑞昔佈鈉預防成人腹腔鏡手術痳醉囌醒期躁動的隨機對照試驗.對符閤納入標準的文獻進行質量評價和資料提取,採用RevMan 5.2.7軟件對囌醒期躁動的髮生率及噁心嘔吐等進行Meta分析.結果 最終納入文獻9篇,共計患者580例.其中帕瑞昔佈鈉組(在痳醉前、痳醉中或痳醉後給予帕瑞昔佈鈉)300例,對照組(在痳醉前、痳醉中或痳醉後給予0.9％氯化鈉註射液)280例.Meta分析結果顯示,與對照組相比,帕瑞昔佈鈉組腹腔鏡手術痳醉囌醒期躁動髮生率更低[相對危險度(RR)=0.23,95％置信區間:0.15 ～ 0.34],囌醒期躁動評分更低(加權均數差=-0.85,95％置信區間:-1.12～-0.57),術後噁心嘔吐髮生率更低(RR=0.34,95％置信區間:0.15～0.78),鎮痛需求更少(RR=0.09,95％置信區間:0.02 ～0.44).結論 本研究錶明帕瑞昔佈鈉超前鎮痛,能有效預防成人腹腔鏡手術痳醉囌醒期躁動,且安全性較高.
목적 계통분석파서석포납예방성인복강경수술마취소성기조동적유효성화안전성,위림상합리용약제공삼고.방법 통과검색PubMed、EBSCO、Springer、Ovid、EMbase、Cochrane Library、Web of Science 화중국기간전문수거고、유보중문과기기간수거고、만방수거고,사조파서석포납예방성인복강경수술마취소성기조동적수궤대조시험.대부합납입표준적문헌진행질량평개화자료제취,채용RevMan 5.2.7연건대소성기조동적발생솔급악심구토등진행Meta분석.결과 최종납입문헌9편,공계환자580례.기중파서석포납조(재마취전、마취중혹마취후급여파서석포납)300례,대조조(재마취전、마취중혹마취후급여0.9％록화납주사액)280례.Meta분석결과현시,여대조조상비,파서석포납조복강경수술마취소성기조동발생솔경저[상대위험도(RR)=0.23,95％치신구간:0.15 ～ 0.34],소성기조동평분경저(가권균수차=-0.85,95％치신구간:-1.12～-0.57),술후악심구토발생솔경저(RR=0.34,95％치신구간:0.15～0.78),진통수구경소(RR=0.09,95％치신구간:0.02 ～0.44).결론 본연구표명파서석포납초전진통,능유효예방성인복강경수술마취소성기조동,차안전성교고.
Objective To provide a systematic review of parecoxib preventing post-laparoscopic-operative emergence agitation in adults plus reliable clinical evidences for an ideal pharmacological management of emergence agitation.Methods A comprehensive literature search was conducted to identify randomized controlled trials that focused on parecoxib preventing emergence agitation post-laparoscopic-operative in adults.The databases included PubMed,EBSCO,Springer,Ovid,EMbase,Cochrane Library,Web of Science and the China Nation Knowledge Infrastructure,Weipu Data Base and Wanfang Data Base.Literature screening had inclusive and exclusive criteria; data extracting,quality assessment and the incidence of emergence agitation,nausea and vomiting were analyzed.Results Nine articles had a total of 580 patients,including 300 cases of parecoxib and 280 cases of saline.The results of meta-analyses showed:compared with normal saline group,parecoxib group had a lower incidence of emergence agitation [relative risk(RR) =0.23,95％ Confidence interval (CI):0.15-0.34],lower RS score (Weighted mean difference =-0.85,95％ CI:-1.12--0.57),lower incidence of postoperative nausea and vomiting(RR =0.34,95％ CI:0.15-0.78),lower analgesic requirement(RR =0.09,95％ CI:0.02-0.44).Conclusion Parecoxib during preemptive analgesia can have a protective effect on emergence agitation.
