CAJ | 학술논문

目的了解有偿献血人群血浆雌二醇(estradiol,E2)及白细胞介素12(interleukin 12,IL-12)水平及其与丙型肝炎病毒(hepatitis C Virus,HCV)感染转归的关系.方法将199例既往有偿献血人群分为健康对照组、自限清除组、持续感染组,检测其血浆E2、IL-12浓度及肝功能指标.结果多因素Logistic回归分析显示献全血史(P=0.040)和单采血浆史(P ＜0.001)是HCV感染的危险因素.未发现血浆E2、IL-12浓度在三组间的差异存在统计学意义(P均＞0.05).血浆E2和IL-12水平存在正相关关系(r =0.672,P＜0.001).结论有偿献血是丙型肝炎传播的一个重要危险因素;E2可能正向调节IL-12的表达,但其对IL-12及HCV感染转归的影响还有待进一步研究.
목적 료해유상헌혈인군혈장자이순(estradiol,E2)급백세포개소12(interleukin 12,IL-12)수평급기여병형간염병독(hepatitis C Virus,HCV)감염전귀적관계.방법 장199례기왕유상헌혈인군분위건강대조조、자한청제조、지속감염조,검측기혈장E2、IL-12농도급간공능지표.결과 다인소Logistic회귀분석현시헌전혈사(P=0.040)화단채혈장사(P ＜0.001)시HCV감염적위험인소.미발현혈장E2、IL-12농도재삼조간적차이존재통계학의의(P균＞0.05).혈장E2화IL-12수평존재정상관관계(r =0.672,P＜0.001).결론 유상헌혈시병형간염전파적일개중요위험인소;E2가능정향조절IL-12적표체,단기대IL-12급HCV감염전귀적영향환유대진일보연구.
Objective To determine the association of plasma estradiol (E2) and interleukin 12 (IL-12) levels with hepatitis C virus (HCV) infection outcomes in paid blood donors.Metbods Totally 199 participants were categorized into three groups,including 72 healthy controls,39 cases who had spontaneous clearance and 88 subjects with persistent HCV infection.We determined all participates' plasma E2concentration,IL-12 level and liver function.Results Multivariate logistic regression analysis showed that the history of full blood donation (P =0.040) and the history of plasma donation (P ＜0.001) were significantly associated with HCV infection.There were no statistically significant differences in the plasma E2 concentration and IL-12 level among the three groups (all P ＞ 0.05).Furthermore,the plasma E2 concentration was positively correlated with IL-12 level (r =0.672,P ＜ 0.001) among the population.Conclusion Paid blood donation is a risk factor of HCV infection.Although our study indicated that estradiol may positively regulate the expression of IL-12,its biological function and effects on IL-12 and HCV infection remains to be elucidated in further large and functional studies.