中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
12期
2676-2677
,共2页
徐卫波%徐文超%侯俊清%刘广超%杜信毅%李铁强
徐衛波%徐文超%侯俊清%劉廣超%杜信毅%李鐵彊
서위파%서문초%후준청%류엄초%두신의%리철강
肾细胞癌%基质金属蛋白酶-2%血管内皮生长因子%生物学行为
腎細胞癌%基質金屬蛋白酶-2%血管內皮生長因子%生物學行為
신세포암%기질금속단백매-2%혈관내피생장인자%생물학행위
Renal cell carcinoma%Matrix metalloproteinase-2%Vascular endothelial growth factor%Biological behavior
目的 探讨基质金属蛋白酶-2(MMP-2)和血管内皮生长因子(VEGF)在肾细胞癌组织中表达的临床意义.方法 选取70例肾细胞癌组织及同期30例正常肾脏组织,采用免疫组织化学方法检测MMP-2、VEGF的表达.结果 肾细胞癌组织中MMP-2和VEGF阳性表达率分别是65.71％和68.57％,且两者表达呈正相关(P＜0.05).两者表达水平均与肿瘤病理分级及临床分期有关.结论 联合检测MMP-2与VEGF有助于反映肾细胞癌生物学行为.
目的 探討基質金屬蛋白酶-2(MMP-2)和血管內皮生長因子(VEGF)在腎細胞癌組織中錶達的臨床意義.方法 選取70例腎細胞癌組織及同期30例正常腎髒組織,採用免疫組織化學方法檢測MMP-2、VEGF的錶達.結果 腎細胞癌組織中MMP-2和VEGF暘性錶達率分彆是65.71％和68.57％,且兩者錶達呈正相關(P＜0.05).兩者錶達水平均與腫瘤病理分級及臨床分期有關.結論 聯閤檢測MMP-2與VEGF有助于反映腎細胞癌生物學行為.
목적 탐토기질금속단백매-2(MMP-2)화혈관내피생장인자(VEGF)재신세포암조직중표체적림상의의.방법 선취70례신세포암조직급동기30례정상신장조직,채용면역조직화학방법검측MMP-2、VEGF적표체.결과 신세포암조직중MMP-2화VEGF양성표체솔분별시65.71％화68.57％,차량자표체정정상관(P＜0.05).량자표체수평균여종류병리분급급림상분기유관.결론 연합검측MMP-2여VEGF유조우반영신세포암생물학행위.
Objective To explore the clinical significance of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) expression in renal cell carcinoma (RCC).Methods The immunohistochemistry staining method was used to evaluate the expression of MMP-2 and VEGF in 70 cases of RCC and 30 cases of normal renal tissue as controls.Results The expression of MMP-2 and VEGF was negatively correlated (P＜0.05),and their positive rate was 65.71％ and 68.57％ respectively.They were related to tumor pathological grade and clinical stage.Conclusion MMP-2 and VEGF are objective markers to estimate the behaviors of RCC.
