中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
12期
2712-2714
,共3页
股动脉粥样硬化%高血压%内脂素%运载蛋白型前列腺素D合成酶
股動脈粥樣硬化%高血壓%內脂素%運載蛋白型前列腺素D閤成酶
고동맥죽양경화%고혈압%내지소%운재단백형전렬선소D합성매
Femoral artery atherosclerosis%Hypertension%Visfatin%Lipocalintype prostaglandin D synthase
目的 探讨血浆脂质运载蛋白型前列腺素D合成酶(L-PGDS)及内脂素水平与人股动脉粥样硬化并高血压及其相关危险因素的关系.方法 根据股动脉内膜-中层厚度(IMT)将152例患者分为股动脉粥样硬化组102例,健康对照组50例.股动脉粥样硬化组根据有无高血压分为股动脉粥样硬化并高血压组(48例),股动脉粥样硬化无高血压组(54例),测定空腹血浆L-PGDS与内脂素水平,所有受试者测定血压、身高、体质量、血脂、空腹血糖,计算体质量指数(BMI).结果 与对照组比较股AS患者血浆内脂素水平为(5.02±2.89) μg/L,明显偏高,血浆L-PGDS水平为(0.58±0.11) mg/L (P＜0.05).股AS合并高血压患者与股AS患者比较,血浆内脂素水平[(28.89 ±4.33) μg/L]及L-PGDS水平[(0.90 ±0.30) mg/L]均明显升高(P＜0.05).血浆内脂素与TG、LDL-C、CRP、BMI、IMT、DBP呈正相关,与年龄、HDL-C呈负相关(P＜0.05),血浆L-PGDS与年龄、SBP呈正相关,与BMI、IMT及LDL-C、CRP水平呈负相关.血浆内脂素与L-PGDS水平呈负相关(P＜0.05).结论 人股动脉粥样硬化并高血压患者血浆内脂素及L-PGDS水平明显改变,可能通过多种途径参与了动脉粥样硬化并高血压病的病理生理过程.
目的 探討血漿脂質運載蛋白型前列腺素D閤成酶(L-PGDS)及內脂素水平與人股動脈粥樣硬化併高血壓及其相關危險因素的關繫.方法 根據股動脈內膜-中層厚度(IMT)將152例患者分為股動脈粥樣硬化組102例,健康對照組50例.股動脈粥樣硬化組根據有無高血壓分為股動脈粥樣硬化併高血壓組(48例),股動脈粥樣硬化無高血壓組(54例),測定空腹血漿L-PGDS與內脂素水平,所有受試者測定血壓、身高、體質量、血脂、空腹血糖,計算體質量指數(BMI).結果 與對照組比較股AS患者血漿內脂素水平為(5.02±2.89) μg/L,明顯偏高,血漿L-PGDS水平為(0.58±0.11) mg/L (P＜0.05).股AS閤併高血壓患者與股AS患者比較,血漿內脂素水平[(28.89 ±4.33) μg/L]及L-PGDS水平[(0.90 ±0.30) mg/L]均明顯升高(P＜0.05).血漿內脂素與TG、LDL-C、CRP、BMI、IMT、DBP呈正相關,與年齡、HDL-C呈負相關(P＜0.05),血漿L-PGDS與年齡、SBP呈正相關,與BMI、IMT及LDL-C、CRP水平呈負相關.血漿內脂素與L-PGDS水平呈負相關(P＜0.05).結論 人股動脈粥樣硬化併高血壓患者血漿內脂素及L-PGDS水平明顯改變,可能通過多種途徑參與瞭動脈粥樣硬化併高血壓病的病理生理過程.
목적 탐토혈장지질운재단백형전렬선소D합성매(L-PGDS)급내지소수평여인고동맥죽양경화병고혈압급기상관위험인소적관계.방법 근거고동맥내막-중층후도(IMT)장152례환자분위고동맥죽양경화조102례,건강대조조50례.고동맥죽양경화조근거유무고혈압분위고동맥죽양경화병고혈압조(48례),고동맥죽양경화무고혈압조(54례),측정공복혈장L-PGDS여내지소수평,소유수시자측정혈압、신고、체질량、혈지、공복혈당,계산체질량지수(BMI).결과 여대조조비교고AS환자혈장내지소수평위(5.02±2.89) μg/L,명현편고,혈장L-PGDS수평위(0.58±0.11) mg/L (P＜0.05).고AS합병고혈압환자여고AS환자비교,혈장내지소수평[(28.89 ±4.33) μg/L]급L-PGDS수평[(0.90 ±0.30) mg/L]균명현승고(P＜0.05).혈장내지소여TG、LDL-C、CRP、BMI、IMT、DBP정정상관,여년령、HDL-C정부상관(P＜0.05),혈장L-PGDS여년령、SBP정정상관,여BMI、IMT급LDL-C、CRP수평정부상관.혈장내지소여L-PGDS수평정부상관(P＜0.05).결론 인고동맥죽양경화병고혈압환자혈장내지소급L-PGDS수평명현개변,가능통과다충도경삼여료동맥죽양경화병고혈압병적병리생리과정.
Objective To investigate the correlation between the plasma levels of lipocalintype prostaglandin D synthase (L-PGDS) and visfatin with its risk factors in human fem-oral atherosclerosis with hypertension.Methods One hundred and fifty-two patients were detected by color Doppler with intimamedia thickness (IMT) measurement.According to IMT,the patients were divided into the femoral atherosclerosis group (n =102),and control group (n =50).The femoral atherosclerosis group was sub-divided into two subgroups:48 cases of femoral AS with hypertension (AS + H) and 54 cases of femoral AS without hypertension (AS).Fasting protein level of L-PGDS and visfatin in plasma,and blood pressure,height,weight,blood lipids,fasting glucose,body mass index (BMI) were measured.Results The level of serum visfatin [(5.02 ± 2.89) μg/L] was significantly increased in AS group as compared with control group,but the level of L-PGDS [(0.58 ± 0.11) mg/L] was significantly decreased in AS group (P ＜0.05).The levels of serum visfatin [(28.89 ±4.33) μg/L] and L-PGDS [(0.90 ±0.30) mg/L] were significantly increased in AS + H subgroup as compared with AS subgroup.Correlation analysis revealed that there was a negative correlation between plasma levels of visfatin and L-PGDS (P ＜ 0.05).Plasma visfatin was positively correlated with TG,LDL-C,CRP,BMI,IMT and DBP,but negatively with age and HDL-C (P ＜ 0.05).Plasma L-PGDS level was positively correlated with age and SBP,but negatively with BMI,IMT,LDL-C and CRP levels (P ＜ 0.05).Conclusion The plasma levels of visfatin and L-PGDS significantly changed in hunan femoral artery atherosclerosis with hypertension,possibly through multiple pathways involved in atherosclerosis with hypertension pathophysiology of the disease.
