中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
12期
2796-2798
,共3页
张明辉%李国军%陈欣欣%武豪杰%王晓
張明輝%李國軍%陳訢訢%武豪傑%王曉
장명휘%리국군%진흔흔%무호걸%왕효
2型糖尿病%硫化氢%骨质疏松
2型糖尿病%硫化氫%骨質疏鬆
2형당뇨병%류화경%골질소송
Type-2 diabetic mellitus%Hydrogen sulfide%Osteoporosis
目的 应用硫化氢对糖尿病骨质疏松模型大鼠干预,观察硫化氢对2型糖尿病骨质疏松的影响.方法 选取2个月龄的SD大鼠90只进行造模,其中25只设立为正常对照组(A组),29只为糖尿病组(B组),30只为硫化氢处理糖尿病组(C组),在造模成功后的2、4、6周对大鼠进行血糖、糖耐量及骨密度测定.结果 2、4、6周后空腹血糖,C组分别为(12.32±2.89)、(13.32±2.12)、(12.42±2.74) mmol/L,B组分别为(14.71 ±4.87)、(16.71 ±5.39)、(17.71±5.23) mmol/L,C组血糖水平相对于B组空腹血糖的状况改善明显,差异有统计学意义(P＜0.05).2、6周后行骨密度测定,C组分别为(1.52±0.21)、(1.24±0.23) g/cm2,B组分别为(1.12 ±0.10)、(1.03±0.10) g/cm2,B组骨密度明显低于C组,差异有统计学意义(P＜0.05).结论 硫化氢可以抑制糖尿病所致的骨质疏松.
目的 應用硫化氫對糖尿病骨質疏鬆模型大鼠榦預,觀察硫化氫對2型糖尿病骨質疏鬆的影響.方法 選取2箇月齡的SD大鼠90隻進行造模,其中25隻設立為正常對照組(A組),29隻為糖尿病組(B組),30隻為硫化氫處理糖尿病組(C組),在造模成功後的2、4、6週對大鼠進行血糖、糖耐量及骨密度測定.結果 2、4、6週後空腹血糖,C組分彆為(12.32±2.89)、(13.32±2.12)、(12.42±2.74) mmol/L,B組分彆為(14.71 ±4.87)、(16.71 ±5.39)、(17.71±5.23) mmol/L,C組血糖水平相對于B組空腹血糖的狀況改善明顯,差異有統計學意義(P＜0.05).2、6週後行骨密度測定,C組分彆為(1.52±0.21)、(1.24±0.23) g/cm2,B組分彆為(1.12 ±0.10)、(1.03±0.10) g/cm2,B組骨密度明顯低于C組,差異有統計學意義(P＜0.05).結論 硫化氫可以抑製糖尿病所緻的骨質疏鬆.
목적 응용류화경대당뇨병골질소송모형대서간예,관찰류화경대2형당뇨병골질소송적영향.방법 선취2개월령적SD대서90지진행조모,기중25지설립위정상대조조(A조),29지위당뇨병조(B조),30지위류화경처리당뇨병조(C조),재조모성공후적2、4、6주대대서진행혈당、당내량급골밀도측정.결과 2、4、6주후공복혈당,C조분별위(12.32±2.89)、(13.32±2.12)、(12.42±2.74) mmol/L,B조분별위(14.71 ±4.87)、(16.71 ±5.39)、(17.71±5.23) mmol/L,C조혈당수평상대우B조공복혈당적상황개선명현,차이유통계학의의(P＜0.05).2、6주후행골밀도측정,C조분별위(1.52±0.21)、(1.24±0.23) g/cm2,B조분별위(1.12 ±0.10)、(1.03±0.10) g/cm2,B조골밀도명현저우C조,차이유통계학의의(P＜0.05).결론 류화경가이억제당뇨병소치적골질소송.
Objective To evaluate the protective effects of hydrogen sulfide supplementation against osteoporosis in diabetic osteoporosis rats.Methods The rat diabetic model was established in 90 two-month-old SD rats,and injected with sodium hydrogen sulfide.The rats were randomly divided into three groups:group A,sham control (SHAM) ; group B,diabetic osteoporosis rats; and group C,rats supplemented with hydrogen sulfide.At 2nd,4th and 6th week after model establishment blood glucose,sugar tolerance and bone density were measured in rats.Results The diabetic rats showed a significant decrease in blood glucose levels.Blood glucose was significantly higher in group B than in group A,and the group C rats fasting blood glucose respected to group B improve significantly,and a significant decrease in measure bone density in A group rats compared to B group rats.Conclusion (1) Hydrogen sulfide have a regulatory role on the metabolism of calcium and phosphorus in the blood.(2) Hydrogen sulfide can improve the situation of osteoporosis.
