CAJ | 학술논문

目的观察触珠蛋白在甲状腺乳头状癌组织中的表达,探讨其在甲状腺乳头状癌发生发展中的作用.方法构建人甲状腺乳头状癌组织微阵列,采用免疫组织化学方法检测触珠蛋白在112例甲状腺乳头状癌,67例结节性甲状腺肿以及50例正常甲状腺组织中的表达.结果 112例甲状腺乳头状癌组织中触珠蛋白阳性表达率为79％,与结节性甲状腺肿(12％)和正常甲状腺组织(8％)比较,差异有统计学意义(P＜0.05).结节性甲状腺肿和正常甲状腺组织触珠蛋白的表达比较差异无统计学意义(P＞0.05).结论触珠蛋白与人甲状腺乳头状癌发生密切相关,而且对甲状腺乳头状癌的发展起重要作用.
목적 관찰촉주단백재갑상선유두상암조직중적표체,탐토기재갑상선유두상암발생발전중적작용.방법 구건인갑상선유두상암조직미진렬,채용면역조직화학방법검측촉주단백재112례갑상선유두상암,67례결절성갑상선종이급50례정상갑상선조직중적표체.결과 112례갑상선유두상암조직중촉주단백양성표체솔위79％,여결절성갑상선종(12％)화정상갑상선조직(8％)비교,차이유통계학의의(P＜0.05).결절성갑상선종화정상갑상선조직촉주단백적표체비교차이무통계학의의(P＞0.05).결론 촉주단백여인갑상선유두상암발생밀절상관,이차대갑상선유두상암적발전기중요작용.
Objective To explore the role of haptoglobin in papillary thyroid carcinoma by applying tissue microarraies.Methods We constructed the tissue microarraies with 11 papillary thyroid carcinomas,67 benign thyroid nodes and 50 normal thyroid tissues.Immunohistochemical method was applied to detect the expression of haptoglobin in papillary thyroid carcinoma,benign thyroid node and normal thyroid tissues.Results In 112 cases of papillary thyroid carcinomas,the positive expression rate of haptoglobin was 79％.Papillary thyroid carcinoma samples expressed much higher haptoglobin levels than benign thyroid node (12％) and normal thyroids (8％,P ＜0.05).However,there was no statistically significant difference in the haptoglobin expression between benign thyroid node and normal thyroid tissues (P ＞0.05).Conclusion Haptoglobin is closely related with the occurrence of human papillary thyroid carcinoma.Furthermore,it may play an important role in development and evolution of this malignant tumor.