CAJ | 학술논문

目的探讨甲胎蛋白(AFP)阳性,癌胚抗原(CEA)阳性胃癌患者临床病理特征及两者联合分析时与胃癌临床病理特征间的关系.方法分析860例胃癌患者术前血清AFP阳性,CEA阳性者的临床病理特征.结果与阴性者比较,AFP阳性患者病理分化程度更低(低分化者92.3％比69.5％),分期更晚(Ⅲ±Ⅳ期88.5％比59.9％),淋巴结阳性率更高(80.8％比59.1％),更易浸润神经(46.2％比27.2％,P＜0.05);CEA阳性患者病理分化程度更低(低分化者78.5％比70.4％),肿瘤浸润层次更深(T4者84.1％比59.4％),分期更晚(Ⅲ+Ⅳ期78.5％比55.0％),淋巴结阳性率更高(75.2％比54.5％),更易浸润脉管(34.1％比21.0％)(P＜0.05).联合分析,AFP(+)-CEA(+)、AFP(+)-CEA(-)、AFP(-)-CEA(+)、AFP(-)-CEA(-)在分化程度、临床分期、淋巴及脉管浸润方面差异有统计学意义(P＜0.05).结论术前血清AFP,CEA阳性与胃癌临床病理密切相关.
목적 탐토갑태단백(AFP)양성,암배항원(CEA)양성위암환자림상병리특정급량자연합분석시여위암림상병리특정간적관계.방법 분석860례위암환자술전혈청AFP양성,CEA양성자적림상병리특정.결과 여음성자비교,AFP양성환자병리분화정도경저(저분화자92.3％비69.5％),분기경만(Ⅲ±Ⅳ기88.5％비59.9％),림파결양성솔경고(80.8％비59.1％),경역침윤신경(46.2％비27.2％,P＜0.05);CEA양성환자병리분화정도경저(저분화자78.5％비70.4％),종류침윤층차경심(T4자84.1％비59.4％),분기경만(Ⅲ+Ⅳ기78.5％비55.0％),림파결양성솔경고(75.2％비54.5％),경역침윤맥관(34.1％비21.0％)(P＜0.05).연합분석,AFP(+)-CEA(+)、AFP(+)-CEA(-)、AFP(-)-CEA(+)、AFP(-)-CEA(-)재분화정도、림상분기、림파급맥관침윤방면차이유통계학의의(P＜0.05).결론 술전혈청AFP,CEA양성여위암림상병리밀절상관.
Objective To evaluate the clinicopathological characteristics of alpha fetal protein (AFP)-positive gastric cancer and carcinoembryonic antigen (CEA)-positive gastric cancer,and combined effect of AFP and CEA on clinicopathological characteristics of gastric cancer.Methods 860 patients with gastric cancer in total were reviewed and the relationship between serum AFP and CEA with clinicopathological factors was analyzed.Results There was poorer differentiation (poor differentiation 92.3％ vs.69.5％),more advanced clinical stage (Ⅲ + Ⅳ stage 88.5％ vs.59.9％),more marked lymphatic (80.8％ vs.59.1％) and nerve invasion (46.2％ vs.27.2％) in AFP-positive gastric cancer patients than in the negative group (P ＜ 0.05).Compared with CEA-negative gastric cancer patients,the CEApositive patients with poorer differentiation (poor differentiation 78.5％ vs.70.4％),deeper depth of invasion (T4,84.1％ vs.59.4％),more advanced clinical stage (m + Ⅳ stage 78.5％ vs.55.0％),more marked lymphatic (75.2％ vs.54.5％) and vascular invasion (34.1％ vs.21.0％) (P ＜ 0.05).The result of combined analysis showed that there was significant difference among AFP (+)-CEA (+),AFP (+)-CEA (-),AFP (-)-CEA (+),and AFP (-)-CEA (-) (P＜0.05).Conclusion The clinicopathological features of AFP-positive or CEA-positive gastric cancer patients were quite different from the negative group.