CAJ | 학술논문

目的探讨染色体1p/19q杂合性缺失与少突胶质细胞肿瘤临床病理特征的关系.方法采用荧光免疫原位杂交技术检测73例少突胶质细胞肿瘤1p/19q杂合性缺失,并随访观察预后.结果少突胶质细胞肿瘤年轻患者(＜ 60岁)1p/19q缺失高于老年患者(＞60岁,P＜0.01);好发部位(额、顶、枕叶)的少突胶质细胞肿瘤1p/19q缺失与其他部位比较差异无统计学意义(P＞0.05),与性别及肿瘤级别均无明显相关(P＞0.05);少突胶质细胞肿瘤患者存在1p/19q联合缺失的中位生存时间为74个月,5年总生存率为72％;仅存在1p缺失者中位生存时间为43个月,5年总生存率为29％;而不存在1p/19q缺失者中位生存时间39个月,5年总生存率为18％.1p/19q联合缺失者中位生存时间长于仅存在1p缺失组,差异有统计学意义(P＜0.05);且1p/19q缺失组中位生存时间也长于1 p/19q未缺失组,差异有统计学意义(P＜0.05).仅存在1p缺失组中位生存时间虽然长于不存在1p/19q缺失组,但差异无统计学意义(Pp＞0.05).结论少突胶质细胞肿瘤1p/19q缺失与患者年龄明显相关,与患者性别、肿瘤发生部位及肿瘤级别无明显相关;少突胶质细胞肿瘤中染色体1p/19q杂合性缺失对患者的化疗敏感性及预后有关,可以作为分子分型的标准.
목적 탐토염색체1p/19q잡합성결실여소돌효질세포종류림상병리특정적관계.방법 채용형광면역원위잡교기술검측73례소돌효질세포종류1p/19q잡합성결실,병수방관찰예후.결과 소돌효질세포종류년경환자(＜ 60세)1p/19q결실고우노년환자(＞60세,P＜0.01);호발부위(액、정、침협)적소돌효질세포종류1p/19q결실여기타부위비교차이무통계학의의(P＞0.05),여성별급종류급별균무명현상관(P＞0.05);소돌효질세포종류환자존재1p/19q연합결실적중위생존시간위74개월,5년총생존솔위72％;부존재1p결실자중위생존시간위43개월,5년총생존솔위29％;이불존재1p/19q결실자중위생존시간39개월,5년총생존솔위18％.1p/19q연합결실자중위생존시간장우부존재1p결실조,차이유통계학의의(P＜0.05);차1p/19q결실조중위생존시간야장우1 p/19q미결실조,차이유통계학의의(P＜0.05).부존재1p결실조중위생존시간수연장우불존재1p/19q결실조,단차이무통계학의의(Pp＞0.05).결론 소돌효질세포종류1p/19q결실여환자년령명현상관,여환자성별、종류발생부위급종류급별무명현상관;소돌효질세포종류중염색체1p/19q잡합성결실대환자적화료민감성급예후유관,가이작위분자분형적표준.
Objective To investigate the relationship between the loss of heterozygosity (LOH)on chromosome 1p/19q and clinicopathologic feature in oligodendroglial tumors.Methods The LOH on chromosome 1 p/19q was detected with fluorescence in situ hybridization in 73 patients with oligodendroglial tumors,and the prognosis was followed up.Results The positive rate of the LOH on chromosome 1p/19q in oligodendroglioma in younger patients (＜ 60 years old) was higher than in older patients (＞ 60 years old),(P ＜ 0.01).There was no statistically significant difference in the LOH on chromosome 1 p/19q betwcen the oligodendroglial tumors at frontal lobe and other lobes (P ＞ 0.05).There was no statistically significant difference in the LOH on chromosome 1p/19q in oligodendroglioma between low grade and high grade (P ＞0.05).There was no statistically significant difference in the LOH on chromosome 1p/19q in oligodendroglioma between males and females.The median survival time of patients with the LOH on chromosome 1 p/19q of oligodendroglioma was 74 months,and total 5-year survival rate was 72％.The median survival time in patients with 1 p LOH was 43 months,and the total 5-year survival rate was 29％.The median survival time of patients without 1 p/19q LOH was 39 months,and total 5-year survival rate was 18％.The median survival time of patients with 1p/19q LOH was significantly longer than that of those with 1 p LOH (P ＜ 0.05).The median survival time of patients with 1 p/19q LOH was significantly longer than that of those without 1 p/19q LOH (P ＜ 0.05).The median survival time of patients with 1 p LOH was longer than that in those without 1p/19q LOH,but there was no statistically significant difference (P＞0.05).Conclusion The LOH on chromosome 1 p/19q in oligodendroglioma was obviously correlated with patients' age,but not with gender,tumor location and tumor grade.There were correlations between the LOH on chromosome 1 p/19q of oligodendroglioma and chemotherapy sensibility and prognosis.The LOH on chromosome 1p/19q of oligodendroglioma can act as the classified standard of molecular subtyping.