中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2014年
12期
2894-2896,封4
,共4页
姜冠潮%廖贻达%李晓%杨帆%王俊
薑冠潮%廖貽達%李曉%楊帆%王俊
강관조%료이체%리효%양범%왕준
肺癌%脑转移%半胱氨酰天冬氨酸特异性蛋白酶-8
肺癌%腦轉移%半胱氨酰天鼕氨痠特異性蛋白酶-8
폐암%뇌전이%반광안선천동안산특이성단백매-8
Lung cancer%Brain metastasis%Cysteinyl aspartate-specific protease-8
目的 探讨半胱氨酰天冬氨酸特异性蛋白酶(Caspase)-8在非小细胞肺癌脑转移中的预测价值.方法 采用免疫组织化学方法研究284例手术治疗的非小细胞肺癌患者Caspase-8的表达,利用Kaplan-Meier法评价脑转移发生时间与Caspase-8表达的关系.结果 284例患者中,女104例,男180例;平均年龄(62.5±10.5)岁;中位随访时间29.5个月(12 ～ 108个月),随访期间共有8.1％ (23/284)的患者发生了脑转移.在Caspase-8高表达组脑转移发生率为14.0％ (15/107),而Caspase-8低表达组脑转移发生率仅为4.5％(8/177).单因素和多因素Cox回归模型提示,Caspase-8是肺癌脑转移的独立危险因素.Caspasc-8高表达能够预测早期的脑转移(Log-rank检验,P＜0.05).结论 Caspase-8高表达与非小细胞肺癌患者术后脑转移明显相关,Caspase-8可以作为肺癌脑转移高危患者筛选的标志.
目的 探討半胱氨酰天鼕氨痠特異性蛋白酶(Caspase)-8在非小細胞肺癌腦轉移中的預測價值.方法 採用免疫組織化學方法研究284例手術治療的非小細胞肺癌患者Caspase-8的錶達,利用Kaplan-Meier法評價腦轉移髮生時間與Caspase-8錶達的關繫.結果 284例患者中,女104例,男180例;平均年齡(62.5±10.5)歲;中位隨訪時間29.5箇月(12 ～ 108箇月),隨訪期間共有8.1％ (23/284)的患者髮生瞭腦轉移.在Caspase-8高錶達組腦轉移髮生率為14.0％ (15/107),而Caspase-8低錶達組腦轉移髮生率僅為4.5％(8/177).單因素和多因素Cox迴歸模型提示,Caspase-8是肺癌腦轉移的獨立危險因素.Caspasc-8高錶達能夠預測早期的腦轉移(Log-rank檢驗,P＜0.05).結論 Caspase-8高錶達與非小細胞肺癌患者術後腦轉移明顯相關,Caspase-8可以作為肺癌腦轉移高危患者篩選的標誌.
목적 탐토반광안선천동안산특이성단백매(Caspase)-8재비소세포폐암뇌전이중적예측개치.방법 채용면역조직화학방법연구284례수술치료적비소세포폐암환자Caspase-8적표체,이용Kaplan-Meier법평개뇌전이발생시간여Caspase-8표체적관계.결과 284례환자중,녀104례,남180례;평균년령(62.5±10.5)세;중위수방시간29.5개월(12 ～ 108개월),수방기간공유8.1％ (23/284)적환자발생료뇌전이.재Caspase-8고표체조뇌전이발생솔위14.0％ (15/107),이Caspase-8저표체조뇌전이발생솔부위4.5％(8/177).단인소화다인소Cox회귀모형제시,Caspase-8시폐암뇌전이적독립위험인소.Caspasc-8고표체능구예측조기적뇌전이(Log-rank검험,P＜0.05).결론 Caspase-8고표체여비소세포폐암환자술후뇌전이명현상관,Caspase-8가이작위폐암뇌전이고위환자사선적표지.
Objective To valuate cysteinyl aspartate-specific protease (Caspase)-8 as a useful marker in predicting non-small cell lung cancer (NSCLC) metastasis to brain.Methods Caspase-8 was detected by immunohistochemistry in 284 NSCLC patients who received surgery during Apr.2004 to Apr.2012.Time to brain metastasis was estimated using Kaplan-Meier method.Results There were 104 females and 180 males in the whole 284 patients.The average age was (62.5 ± 10.5) years (29-85 years).The median follow-up time was 29.5 months (12-108 months).There was 8.1％ (23/284) of the patients who experienced brain metastasis.Brain metastasis was identified in 14.0％ (15/107) patients in Caspase-8 high expression group,and only 4.5％ (8/177) patients in low level group developed brain metastasis.Univariate logistic regression and multivariable Cox regression analysis demonstrated Caspase-8 was an independent variable affecting lung cancer brain metastasis.Elevated Caspase-8 predicted early spread to brain (Log-rank test,P ＜ 0.05).Conclusion High level of Caspase-8 was associated with increased incidence of brain metastasis after surgery in NSCLC patients.Caspase-8 can be used as a biomarker for identification of patients at high risk of brain metastasis.
