CAJ | 학술논문

目的探讨肺大细胞神经内分泌癌患者手术治疗前后外周血中性粒细胞/淋巴细胞比值(NLR)对预后的影响.方法分析28例肺大细胞神经内分泌癌患者临床资料,单因素分析年龄、吸烟指数、病理类型、肿瘤分期、术前术后NLR、和术前NLR/术后NLR比值等对预后的影响,差异有统计学意义的单因素进入Cox回归模型进行多因素分析.结果单因素分析显示年龄(P＜0.05)、吸烟指数(P＜0.05)、病理类型(P＜0.05)、肿瘤分期(P＜0.05)、术前NLR≥2.5(P ＜0.05)和术后NLR≥3.5(P＜0.05)影响患者预后.Cox回归分析显示肿瘤分期(P＜0.05)、术前NLR≥2.5(P ＜0.05)和术后NLR≥3.5(P ＜0.05)为影响患者术后生存率的独立危险因素.结论对于接受手术的肺大细胞神经内分泌癌患者,术前术后NLR升高可能提示其预后不良.
목적 탐토폐대세포신경내분비암환자수술치료전후외주혈중성립세포/림파세포비치(NLR)대예후적영향.방법 분석28례폐대세포신경내분비암환자림상자료,단인소분석년령、흡연지수、병리류형、종류분기、술전술후NLR、화술전NLR/술후NLR비치등대예후적영향,차이유통계학의의적단인소진입Cox회귀모형진행다인소분석.결과 단인소분석현시년령(P＜0.05)、흡연지수(P＜0.05)、병리류형(P＜0.05)、종류분기(P＜0.05)、술전NLR≥2.5(P ＜0.05)화술후NLR≥3.5(P＜0.05)영향환자예후.Cox회귀분석현시종류분기(P＜0.05)、술전NLR≥2.5(P ＜0.05)화술후NLR≥3.5(P ＜0.05)위영향환자술후생존솔적독립위험인소.결론 대우접수수술적폐대세포신경내분비암환자,술전술후NLR승고가능제시기예후불량.
Objective To analyze the impact of pre-and postoperative neutrophil-lymphocyte ratio (NLR) on the survival of patients with pulmonary large cell neuroendocrine carcinoma (LCNEC).Methods The clinical data of 28 patients with pulmonary LCNEC were retrospectively reviewed,and the predictors of univariate analyses included gender,age,smoking history,pathological type and tumor stage,pre-and postoperative neutrophil-lymphocyte ratio (NLR) and preoperative NLR/postoperative NLR,etc.The analysis of Cox multiple regression was performed to determine the parameters of predicting the LCNEC prognosis.Results Univariate analysis showed that age (P ＜ 0.05),smoking history (P ＜ 0.05),pathological type (P ＜ 0.05),tumor stage (P ＜ 0.05),preoperative NLR ≥2.5 (P ＜ 0.05) and postoperative NLR ≥ 3.5 (P ＜ 0.05) were prognostic factors.Multivariate analysis revealed that tumor stage (P ＜0.05),preoperative NLR ≥2.5 (P ＜0.05) and postoperative NLR ≥3.5 (P ＜ 0.05) were independent prognostic factors.Conclusion The elevated pre-and postoperative NLR may predict the LCNEC patients with a poor prognosis after surgery.