中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2014年
6期
558-561
,共4页
洪婷婷%汪军%孟忻%高新晓%刘广峰%范颖%顾铮%贾宇颂%王华
洪婷婷%汪軍%孟忻%高新曉%劉廣峰%範穎%顧錚%賈宇頌%王華
홍정정%왕군%맹흔%고신효%류엄봉%범영%고쟁%가우송%왕화
糖尿病视网膜病变/并发症%黄斑水肿%视觉障碍/病理生理学%体层摄影术,光学相干
糖尿病視網膜病變/併髮癥%黃斑水腫%視覺障礙/病理生理學%體層攝影術,光學相榦
당뇨병시망막병변/병발증%황반수종%시각장애/병리생이학%체층섭영술,광학상간
Diabetic retinopathy/complications%Macular edema%Vision disorders/ physiopathology%Tomography,optical coherence
目的 观察糖尿病黄斑水肿(DME)患眼不同眼底自身荧光(FAF)和光相干断层扫描(OCT)图像分型以及黄斑中心凹视网膜厚度(CRT)、黄斑体积与最佳矫正视力(BCVA)的关系.方法 临床检查确诊的DME患者47例84只眼纳入研究.所有患眼均行BCVA、眼底彩色照相、FAF、OCT检查.根据FAF检查结果,将患眼分为正常组、单囊样增强组、多囊样增强组;OCT检查结果,将患眼分为弥漫水肿型、囊样水肿型、浆液视网膜脱离型.其中,正常组、单囊样增强组、多囊样增强组分别为30、20、34只眼;OCT检查所见的弥漫水肿、囊样水肿、浆液视网膜脱离分别为44、18、22只眼.统计FAF各组中不同OCT分型者的比例;不同FAF分型患眼BCVA、平均CRT、平均黄斑体积的关系;不同OCT分型患眼平均CRT、平均黄斑体积与BCVA的关系.结果 患眼平均BCVA 0.38±0.26;平均CRT(360.23±139.40) μm;平均黄斑体积(9.59±1.97) mm3.正常组、单囊样增强组中,弥漫水肿型患眼分别占本组患眼的83.3％、60.0％;多囊样增强组中浆液视网膜脱离型患眼占本组患眼的50.0％.正常组、单囊样增强组、多囊样增强组患眼平均BCVA分别为0.47±0.26、0.43±0.30、0.28±0.19;平均CRT分别为(275.50±58.22)、(315.50±100.55)、(461.29±147.68) μm;平均黄斑体积分别为(8.67±1.03)、(8.94±1.63)、(10.79±2.20) mm3.3组间平均BCVA(x2 =11.34)、CRT(x2 =30.25)、黄斑体积(x2=20.14)比较,差异有统计学意义(P＜0.05).弥漫水肿型、囊样水肿型、浆液脱离型患眼平均BVCA分别为0.43±0.25、0.45±0.30、0.22±0.14;平均CRT分别为(272.41±48.62)、(402.84±134.89)、(505.67±135.20) μm;平均黄斑体积分别为(8.58±0.95)、(9.22±1.33)、(12.03±2.01)mm3.不同类型黄斑水肿患眼平均BCVA(x2=11.79)、CRT(x2 =42.38)、黄斑体积(x2=39.00)比较,差异有统计学意义(P＜0.05).相关性分析结果显示,CRT与黄斑体积呈显著相关(r=0.85,P＜0.05);BCVA与CRT、黄斑体积呈负相关(r=-0.31、-0.34,P＞0.05).结论 正常组、单囊样增强组弥漫水肿型患眼最多,多囊样增强组浆液脱离型患眼最多.FAF分型较OCT分型,与视力的关系更加密切.
目的 觀察糖尿病黃斑水腫(DME)患眼不同眼底自身熒光(FAF)和光相榦斷層掃描(OCT)圖像分型以及黃斑中心凹視網膜厚度(CRT)、黃斑體積與最佳矯正視力(BCVA)的關繫.方法 臨床檢查確診的DME患者47例84隻眼納入研究.所有患眼均行BCVA、眼底綵色照相、FAF、OCT檢查.根據FAF檢查結果,將患眼分為正常組、單囊樣增彊組、多囊樣增彊組;OCT檢查結果,將患眼分為瀰漫水腫型、囊樣水腫型、漿液視網膜脫離型.其中,正常組、單囊樣增彊組、多囊樣增彊組分彆為30、20、34隻眼;OCT檢查所見的瀰漫水腫、囊樣水腫、漿液視網膜脫離分彆為44、18、22隻眼.統計FAF各組中不同OCT分型者的比例;不同FAF分型患眼BCVA、平均CRT、平均黃斑體積的關繫;不同OCT分型患眼平均CRT、平均黃斑體積與BCVA的關繫.結果 患眼平均BCVA 0.38±0.26;平均CRT(360.23±139.40) μm;平均黃斑體積(9.59±1.97) mm3.正常組、單囊樣增彊組中,瀰漫水腫型患眼分彆佔本組患眼的83.3％、60.0％;多囊樣增彊組中漿液視網膜脫離型患眼佔本組患眼的50.0％.正常組、單囊樣增彊組、多囊樣增彊組患眼平均BCVA分彆為0.47±0.26、0.43±0.30、0.28±0.19;平均CRT分彆為(275.50±58.22)、(315.50±100.55)、(461.29±147.68) μm;平均黃斑體積分彆為(8.67±1.03)、(8.94±1.63)、(10.79±2.20) mm3.3組間平均BCVA(x2 =11.34)、CRT(x2 =30.25)、黃斑體積(x2=20.14)比較,差異有統計學意義(P＜0.05).瀰漫水腫型、囊樣水腫型、漿液脫離型患眼平均BVCA分彆為0.43±0.25、0.45±0.30、0.22±0.14;平均CRT分彆為(272.41±48.62)、(402.84±134.89)、(505.67±135.20) μm;平均黃斑體積分彆為(8.58±0.95)、(9.22±1.33)、(12.03±2.01)mm3.不同類型黃斑水腫患眼平均BCVA(x2=11.79)、CRT(x2 =42.38)、黃斑體積(x2=39.00)比較,差異有統計學意義(P＜0.05).相關性分析結果顯示,CRT與黃斑體積呈顯著相關(r=0.85,P＜0.05);BCVA與CRT、黃斑體積呈負相關(r=-0.31、-0.34,P＞0.05).結論 正常組、單囊樣增彊組瀰漫水腫型患眼最多,多囊樣增彊組漿液脫離型患眼最多.FAF分型較OCT分型,與視力的關繫更加密切.
목적 관찰당뇨병황반수종(DME)환안불동안저자신형광(FAF)화광상간단층소묘(OCT)도상분형이급황반중심요시망막후도(CRT)、황반체적여최가교정시력(BCVA)적관계.방법 림상검사학진적DME환자47례84지안납입연구.소유환안균행BCVA、안저채색조상、FAF、OCT검사.근거FAF검사결과,장환안분위정상조、단낭양증강조、다낭양증강조;OCT검사결과,장환안분위미만수종형、낭양수종형、장액시망막탈리형.기중,정상조、단낭양증강조、다낭양증강조분별위30、20、34지안;OCT검사소견적미만수종、낭양수종、장액시망막탈리분별위44、18、22지안.통계FAF각조중불동OCT분형자적비례;불동FAF분형환안BCVA、평균CRT、평균황반체적적관계;불동OCT분형환안평균CRT、평균황반체적여BCVA적관계.결과 환안평균BCVA 0.38±0.26;평균CRT(360.23±139.40) μm;평균황반체적(9.59±1.97) mm3.정상조、단낭양증강조중,미만수종형환안분별점본조환안적83.3％、60.0％;다낭양증강조중장액시망막탈리형환안점본조환안적50.0％.정상조、단낭양증강조、다낭양증강조환안평균BCVA분별위0.47±0.26、0.43±0.30、0.28±0.19;평균CRT분별위(275.50±58.22)、(315.50±100.55)、(461.29±147.68) μm;평균황반체적분별위(8.67±1.03)、(8.94±1.63)、(10.79±2.20) mm3.3조간평균BCVA(x2 =11.34)、CRT(x2 =30.25)、황반체적(x2=20.14)비교,차이유통계학의의(P＜0.05).미만수종형、낭양수종형、장액탈리형환안평균BVCA분별위0.43±0.25、0.45±0.30、0.22±0.14;평균CRT분별위(272.41±48.62)、(402.84±134.89)、(505.67±135.20) μm;평균황반체적분별위(8.58±0.95)、(9.22±1.33)、(12.03±2.01)mm3.불동류형황반수종환안평균BCVA(x2=11.79)、CRT(x2 =42.38)、황반체적(x2=39.00)비교,차이유통계학의의(P＜0.05).상관성분석결과현시,CRT여황반체적정현저상관(r=0.85,P＜0.05);BCVA여CRT、황반체적정부상관(r=-0.31、-0.34,P＞0.05).결론 정상조、단낭양증강조미만수종형환안최다,다낭양증강조장액탈리형환안최다.FAF분형교OCT분형,여시력적관계경가밀절.
Objective To assess and classify the features of fundus autofluorescence (FAF) with optical coherence tomography (OCT) in clinically significant diabetic macular edema according to the criteria reported by ETDRS.Methods Eighty-four eyes of 47 diabetic patients with untreated clinically significant macular edema (CSME) diagnosed by OCT/FAF examination were enrolled in this study.The mean BCVA was 0.38±0.26,CRT was (360.23±139.40) μm and volume was (9.59±1.97) mm3.According to the FAF patterns,the CSME patients were divided into normal group (30 eyes),single-spot group (20 eyes),and multiple-spot group (22 eyes).There were 44,18 and 22 eyes with diffuse edema,cystoid edema and serous retinal detachment,respectively.The correlation of visual acuity with central retinal thickness and total volume of macular was analyzed between different groups.Results In the normal group and the singlespot group,the prevalence of the diffuse type was highest in the OCT (83.3％,60.0％).In the multiplespot group,the prevalence of the SRD type was highest in the OCT (50.0％).In the three FAF pattern groups,the BCVA were 0.47±0.26,0.43±0.30,0.28±0.19; the CRT were (272.41±48.62),(402.84±134.89),(505.67±135.20) μm ; the total volume was (8.67± 1.03),(8.94± 1.63),(10.79±2.20) mm3.The BCVA were 0.43±0.25,0.45±0.30,0.22±0.14; the CRT were (272.41± 48.62),(402.84±134.89),(505.67± 135.20) μm ; the total volume was (8.58±0.95)、(9.22± 1.33)、(12.03±2.01) mm3 in eyes with diffuse edema,cystoid edema and serous retinal detachment,respectively (r=-0.31,-0.34; P＞ 0.05).Correlation analysis showed CRT positively correlated to volume (r=0.85,P＜ 0.05),BCVA negatively correlated to CRT and volume (r=-0.31,-0.34; P＞ 0.05).Conclusion There are more diffuse edema eyes in normal group and single-spot group,while serous retinal detachmen in multiple-spot group.FAF correlates better with visual acuity than OCT patterns.
