中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2014年
12期
952-958
,共7页
糖尿病视网膜病变%视网膜新生血管化%内皮,血管%内皮细胞%伪足%血管内皮生长因子A
糖尿病視網膜病變%視網膜新生血管化%內皮,血管%內皮細胞%偽足%血管內皮生長因子A
당뇨병시망막병변%시망막신생혈관화%내피,혈관%내피세포%위족%혈관내피생장인자A
Diabetic retinopathy%Retinal neovascularization%Endothelium,vascular%Endothelial cells%Pseudopodia%Vascular endothelial growth factor A
尖细胞是血管内皮细胞的一种,其迁移和出芽是新生血管产生的使动因素.近年来的临床和基础研究发现糖尿病视网膜病变(DR)患者和动物模型的新生血管中存在大量的尖细胞,血管内皮生长因子(VEGF)调控尖细胞的迁移和出芽,降解细胞外基质,在VEGF-Delta like-Notch信号指引下募集周细胞,形成新生血管;而同时尖细胞中miRNA的表达改变也参与新生血管的调控.本文就尖细胞在DR中的作用机制进行综述,对抗新生血管药物靶点研究的前景进行展望.
尖細胞是血管內皮細胞的一種,其遷移和齣芽是新生血管產生的使動因素.近年來的臨床和基礎研究髮現糖尿病視網膜病變(DR)患者和動物模型的新生血管中存在大量的尖細胞,血管內皮生長因子(VEGF)調控尖細胞的遷移和齣芽,降解細胞外基質,在VEGF-Delta like-Notch信號指引下募集週細胞,形成新生血管;而同時尖細胞中miRNA的錶達改變也參與新生血管的調控.本文就尖細胞在DR中的作用機製進行綜述,對抗新生血管藥物靶點研究的前景進行展望.
첨세포시혈관내피세포적일충,기천이화출아시신생혈관산생적사동인소.근년래적림상화기출연구발현당뇨병시망막병변(DR)환자화동물모형적신생혈관중존재대량적첨세포,혈관내피생장인자(VEGF)조공첨세포적천이화출아,강해세포외기질,재VEGF-Delta like-Notch신호지인하모집주세포,형성신생혈관;이동시첨세포중miRNA적표체개변야삼여신생혈관적조공.본문취첨세포재DR중적작용궤제진행종술,대항신생혈관약물파점연구적전경진행전망.
Tip cells are one kind of vascular endothelial cells.Migration and sprouting of tip cells is the first step of angiogenesis.In recent years,researchers found a large number of tip endothelial cells in new blood vessels of diabetic retinopathy patients and animal models.Vascular endothelial growth factor (VEGF) regulates the migration and budding of tip cells and dissolves the extracellular matrix.Pericyte recruitment guided by the VEGF-DLL-Notch signal pathway is necessary for neovascularization.The change of miRNA in tip cells is also involved in the regulation of angiogenesis.This paper focuses on the mechanism of endothelial tip cells in diabetic retinopathy and prospects for the future research of anti-angiogenesis drug targets.(Chin J Ophthalmol,2014,50:952-958)
