CAJ | 학술논문

目的采用优化的基于体素的形态学测量(OVBM)的方法初步探讨注意缺陷多动障碍(ADHD)儿童全脑灰质结构左右非对称性异常.方法 2005年1月至2006年12月在北京大学第六医院门诊、符合美国精神障碍诊断与统计手册第四版(DSM-Ⅳ)中ADHD诊断标准的25例男孩(ADHD组)及27名年龄、性别、利手相匹配的正常对照(对照组),使用定式临床诊断性会谈量表(CDIS)进行临床诊断及分型,采集结构磁共振成像(MRI)数据,使用OVBM的方法,计算出全脑灰质每个体素的非对称性指数(AI),对AI进行组间比较.结果两组被试全脑灰质的非对称模式相似,组间比较发现ADHD患者额上回(MNI坐标:17,49,26)及额中回(MNI坐标:33,-5,63)的非对称性与正常对照的左＞右的模式相反(经过整体错误率进行多重比较校正至P ＜0.05).结论 ADHD儿童存在前额叶灰质左右非对称性的异常,非对称性异常可能是ADHD的神经病理机制之一.
목적 채용우화적기우체소적형태학측량(OVBM)적방법초보탐토주의결함다동장애(ADHD)인동전뇌회질결구좌우비대칭성이상.방법 2005년1월지2006년12월재북경대학제륙의원문진、부합미국정신장애진단여통계수책제사판(DSM-Ⅳ)중ADHD진단표준적25례남해(ADHD조)급27명년령、성별、리수상필배적정상대조(대조조),사용정식림상진단성회담량표(CDIS)진행림상진단급분형,채집결구자공진성상(MRI)수거,사용OVBM적방법,계산출전뇌회질매개체소적비대칭성지수(AI),대AI진행조간비교.결과 량조피시전뇌회질적비대칭모식상사,조간비교발현ADHD환자액상회(MNI좌표:17,49,26)급액중회(MNI좌표:33,-5,63)적비대칭성여정상대조적좌＞우적모식상반(경과정체착오솔진행다중비교교정지P ＜0.05).결론 ADHD인동존재전액협회질좌우비대칭성적이상,비대칭성이상가능시ADHD적신경병리궤제지일.
Objective Mounting evidence suggests that attention deficit/hyperactivity disorder (ADHD) is related with abnormal anatomical asymmetry in some brain regions,such as basal ganglia.However,few cross-sectional studies have examined the abnormalities of anatomical asymmetry in whole brain of ADHD.Thus this cross-sectional study was to explore the anatomical asymmetry in whole brain of ADHD with optimized voxel-based morphometry (OVBM).Methods Twenty-five boys with ADHD and 27 age and gender-matched controls were recruited.All participants were right-handed.The grey matter concentration of each voxel was calculated with OVBM.A statistical evaluation of grey matter asymmetry was then conducted on normalized grey matter images and their flipped counterparts.Results One-sample t-test revealed that the whole-brain anatomical asymmetry pattern was similar in two groups.Through group comparisons,ADHD showed reversed left-greater-than-right asymmetry in superior and middle frontal gyri versus controls.Conclusion Anatomical asymmetry of prefrontal cortex is abnormal in children with ADHD.And abnormal anatomical asymmetry may play an important role in the pathophysiology of ADHD.