CAJ | 학술논문

目的观察国产替吉奥胶囊联合三维适型放疗治疗老年责门癌的疗效及安全性.方法 2009年1月至2011年9月收治46例老年贲门癌患者,排除放化疗禁忌证后,第1周期化疗开始口服国产替吉奥胶囊(维康达)40 mg,2次/d,第1～14天,21 d为1个周期,同步贲门原发病灶及周围淋巴结行三维适型放疗,1.8 Gy/次,每周5次,DT39.6 ～ 54.0 Gy,4～5.5周完成放疗,继续完成共3～6个周期的化疗.治疗过程中观察患者的消化道不良反应、骨髓抑制情况和治疗耐受性.治疗结束后观察近期疗效并随访1、2年生存率.结果放疗结束2、4个月消化道症状得到改善,总有效率(完全缓解率+部分缓解率)为82.6％,1年生存率为84.7％,2年生存率为65.2％.结论国产替吉奥胶囊低剂量口服化疗联合三维适型放疗治疗老年贲门癌,不良反应可耐受,安全性可,对因失去手术机会、拒绝静脉化疗或手术的老年贲门癌患者改善吞咽困难和疼痛症状,提高生存期,具有一定的临床疗效,推荐临床进一步研究.
목적 관찰국산체길오효낭연합삼유괄형방료치료노년책문암적료효급안전성.방법 2009년1월지2011년9월수치46례노년분문암환자,배제방화료금기증후,제1주기화료개시구복국산체길오효낭(유강체)40 mg,2차/d,제1～14천,21 d위1개주기,동보분문원발병조급주위림파결행삼유괄형방료,1.8 Gy/차,매주5차,DT39.6 ～ 54.0 Gy,4～5.5주완성방료,계속완성공3～6개주기적화료.치료과정중관찰환자적소화도불량반응、골수억제정황화치료내수성.치료결속후관찰근기료효병수방1、2년생존솔.결과 방료결속2、4개월소화도증상득도개선,총유효솔(완전완해솔+부분완해솔)위82.6％,1년생존솔위84.7％,2년생존솔위65.2％.결론 국산체길오효낭저제량구복화료연합삼유괄형방료치료노년분문암,불량반응가내수,안전성가,대인실거수술궤회、거절정맥화료혹수술적노년분문암환자개선탄인곤난화동통증상,제고생존기,구유일정적림상료효,추천림상진일보연구.
Objective To observe the curative effect and safety of the domestic type for S-1 capsule combined the three-dimensional conformal radiotherapy (3-DCT) in the treatment of aged patients with cardiac cancer.Methods Forty-six elderly patients with cardia cancer were studied from January 2009 to September 2011.After ruling out the contraindications of chemotherapy and radiotherapy,the patients were given oral chemotherapy with the domestic S-1 capsules (Weikangda),40 mg,2 times/day,d1-14,21 days for one circle,combined with synchronous three dimentional conformal radiation on local primay lessions and metastatic nudes.It' s dose was 1.8 Gy/time,five times a week,DT 39.6-54 Gy.It took 4-5.5 weeks to complete the radiation,following with a total 3-6 cycles of chemotherapy.The gastrointestinal side effects and bone marrow suppression were observed,and the treatment tolerance were researched during the treatment.The recent curative effect and follow-up of 1,2 year survival rate were studied.Results The patients' digestive tract symptoms were improved after radiation over 2 months and 4 months.The objective response rate (CR + PR) was 82.6％,1 year survival rate was 84.7％ and 2 year survival rate was 65.2％.Conclusions The domestic type for S-1 capsule combined the three-dimensional conformal radiotherapy (3-DCT) in the treatment of aged patients with cardiac cancer is practicable and safe,the clinical currative effect is better and the further clinical research is recommend.