中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
1期
24-25
,共2页
吕帅国%李长生%李廷坤%汪蕾%孙亚林%卢锡华
呂帥國%李長生%李廷坤%汪蕾%孫亞林%盧錫華
려수국%리장생%리정곤%왕뢰%손아림%로석화
帕瑞昔布钠%炎症%导管消融术%肝肿瘤
帕瑞昔佈鈉%炎癥%導管消融術%肝腫瘤
파서석포납%염증%도관소융술%간종류
Parecoxib%Inflammation%Catheter ablation%Liver neoplasms
目的 评价帕瑞昔布钠对CT引导下经皮肝癌射频消融术患者术后炎性反应的影响.方法 择期行CT引导下经皮肝癌射频消融术的患者40例,性别不限,年龄45～68岁,体质量48 ～75 kg,ASA分级Ⅱ或Ⅲ级,肝功能Child-Pugh分级A级,采用随机数字表法将患者分为对照组(C组)和帕瑞昔布钠组(P组),每组20例.麻醉诱导:静脉注射异丙酚1～2 mg/kg和芬太尼2～4 μg/kg,插入喉罩后行机械通气.麻醉维持:吸入2％七氟醚,靶控输注瑞芬太尼,血浆靶浓度4 μg/L.术中维持BIS值45 ～60.P组于手术开始时静脉注射帕瑞昔布钠40 mg,C组给予等容量氯化钠注射液.分别于麻醉前、术后2h、24h和48 h时抽取上肢静脉血样,测定血浆肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)的浓度.结果 与C组比较,P组术后2h、24 h和48 h时血浆TNF-α和IL-8的浓度降低(P＜0.05).结论 帕瑞昔布钠可降低CT引导下经皮肝癌射频消融患者术后全身炎性反应.
目的 評價帕瑞昔佈鈉對CT引導下經皮肝癌射頻消融術患者術後炎性反應的影響.方法 擇期行CT引導下經皮肝癌射頻消融術的患者40例,性彆不限,年齡45～68歲,體質量48 ～75 kg,ASA分級Ⅱ或Ⅲ級,肝功能Child-Pugh分級A級,採用隨機數字錶法將患者分為對照組(C組)和帕瑞昔佈鈉組(P組),每組20例.痳醉誘導:靜脈註射異丙酚1～2 mg/kg和芬太尼2～4 μg/kg,插入喉罩後行機械通氣.痳醉維持:吸入2％七氟醚,靶控輸註瑞芬太尼,血漿靶濃度4 μg/L.術中維持BIS值45 ～60.P組于手術開始時靜脈註射帕瑞昔佈鈉40 mg,C組給予等容量氯化鈉註射液.分彆于痳醉前、術後2h、24h和48 h時抽取上肢靜脈血樣,測定血漿腫瘤壞死因子-α(TNF-α)和白細胞介素-8(IL-8)的濃度.結果 與C組比較,P組術後2h、24 h和48 h時血漿TNF-α和IL-8的濃度降低(P＜0.05).結論 帕瑞昔佈鈉可降低CT引導下經皮肝癌射頻消融患者術後全身炎性反應.
목적 평개파서석포납대CT인도하경피간암사빈소융술환자술후염성반응적영향.방법 택기행CT인도하경피간암사빈소융술적환자40례,성별불한,년령45～68세,체질량48 ～75 kg,ASA분급Ⅱ혹Ⅲ급,간공능Child-Pugh분급A급,채용수궤수자표법장환자분위대조조(C조)화파서석포납조(P조),매조20례.마취유도:정맥주사이병분1～2 mg/kg화분태니2～4 μg/kg,삽입후조후행궤계통기.마취유지:흡입2％칠불미,파공수주서분태니,혈장파농도4 μg/L.술중유지BIS치45 ～60.P조우수술개시시정맥주사파서석포납40 mg,C조급여등용량록화납주사액.분별우마취전、술후2h、24h화48 h시추취상지정맥혈양,측정혈장종류배사인자-α(TNF-α)화백세포개소-8(IL-8)적농도.결과 여C조비교,P조술후2h、24 h화48 h시혈장TNF-α화IL-8적농도강저(P＜0.05).결론 파서석포납가강저CT인도하경피간암사빈소융환자술후전신염성반응.
Objective To investigate the effects of parecoxib on inflammatory response in patients after CT-guided percutaneous radio-frequency ablation (RFA) for liver cancer.Methods Forty ASA Ⅱ or Ⅲ and Child-Pugh A patients of both sexes aged 45-68 years old,weighing 48-75 kg,undergoing CT-guided percutaneous radio-frequency ablation for liver cancer,were randomly divided into two groups (n =20 each):control group (group C) and parecoxib group (group P).Anesthesia was induced with propofol 1-2 mg/kg and fentanyl 2-4 pg/kg and maintained with inhalation of 2％ sevoflurane and TCI remifentanil(Cp 4μg/L).Laryngeal mask airway was inserted,and the patients were mechanically ventilated.BIS value was maintained at 45-60.Blood samples were taken from veins of upper limb before surgery(T0) and at 2 h,24 h and 48 h after surgery(T1-3) for determination of plasma TNF-αand IL-8 concentrations.Results Compared with group C,plasma concentrations of TNF-α and IL-8 were significantly decreased at 2 h,24 h and 48 h after operation in group P(P ＜0.05).Conclusions Parecoxib can reduce the inflammatory response after CT-guided percutaneous radio-frequency ablation for liver cancer.
