中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
1期
62-64
,共3页
黄斑水肿%雷珠单抗%激光
黃斑水腫%雷珠單抗%激光
황반수종%뢰주단항%격광
Macular edema%Ranibizumab%Laser
目的 比较雷珠单抗玻璃体腔内注射联合激光和曲安奈德玻璃体腔内注射联合激光治疗糖尿病性黄斑水肿的效果.方法 将84例(90眼)糖尿病性黄斑水肿患者按照数字表法随机分为两组,观察组42例(44眼)采用雷珠单抗玻璃体腔内注射联合激光治疗,对照组42例(46眼)采用曲安奈德玻璃体腔内注射联合激光治疗.治疗后1、3、6、12个月对患者行视力、眼底、眼底荧光血管造影、黄斑区视网膜厚度检查.结果 观察组治疗后1、3、6、12个月时显效率为70.5％、79.6％、76.2％、70.7％;对照组治疗后1、3、6、12个月时显效率为69.6％、80.4％、69.4％、60.0％,两组治疗后1、3个月显效率比较差异无统计学意义(t=0.7246、0.3094,P＞0.05),观察组治疗后6、12个月显效率明显高于对照组(t =3.7068、5.7728,P＜0.05).观察组治疗后12个月视力变化较对照组更明显(t=2.0962,P＜0.05).观察组治疗后6、12个月黄斑中心凹视网膜厚度变化比对照组更明显(t=5.7206,3.6258,P＜0.05).结论 在治疗糖尿病性黄斑水肿中,雷珠单抗玻璃体腔内注射联合激光远期效果优于曲安奈德玻璃体腔内注射联合激光治疗.
目的 比較雷珠單抗玻璃體腔內註射聯閤激光和麯安奈德玻璃體腔內註射聯閤激光治療糖尿病性黃斑水腫的效果.方法 將84例(90眼)糖尿病性黃斑水腫患者按照數字錶法隨機分為兩組,觀察組42例(44眼)採用雷珠單抗玻璃體腔內註射聯閤激光治療,對照組42例(46眼)採用麯安奈德玻璃體腔內註射聯閤激光治療.治療後1、3、6、12箇月對患者行視力、眼底、眼底熒光血管造影、黃斑區視網膜厚度檢查.結果 觀察組治療後1、3、6、12箇月時顯效率為70.5％、79.6％、76.2％、70.7％;對照組治療後1、3、6、12箇月時顯效率為69.6％、80.4％、69.4％、60.0％,兩組治療後1、3箇月顯效率比較差異無統計學意義(t=0.7246、0.3094,P＞0.05),觀察組治療後6、12箇月顯效率明顯高于對照組(t =3.7068、5.7728,P＜0.05).觀察組治療後12箇月視力變化較對照組更明顯(t=2.0962,P＜0.05).觀察組治療後6、12箇月黃斑中心凹視網膜厚度變化比對照組更明顯(t=5.7206,3.6258,P＜0.05).結論 在治療糖尿病性黃斑水腫中,雷珠單抗玻璃體腔內註射聯閤激光遠期效果優于麯安奈德玻璃體腔內註射聯閤激光治療.
목적 비교뢰주단항파리체강내주사연합격광화곡안내덕파리체강내주사연합격광치료당뇨병성황반수종적효과.방법 장84례(90안)당뇨병성황반수종환자안조수자표법수궤분위량조,관찰조42례(44안)채용뢰주단항파리체강내주사연합격광치료,대조조42례(46안)채용곡안내덕파리체강내주사연합격광치료.치료후1、3、6、12개월대환자행시력、안저、안저형광혈관조영、황반구시망막후도검사.결과 관찰조치료후1、3、6、12개월시현효솔위70.5％、79.6％、76.2％、70.7％;대조조치료후1、3、6、12개월시현효솔위69.6％、80.4％、69.4％、60.0％,량조치료후1、3개월현효솔비교차이무통계학의의(t=0.7246、0.3094,P＞0.05),관찰조치료후6、12개월현효솔명현고우대조조(t =3.7068、5.7728,P＜0.05).관찰조치료후12개월시력변화교대조조경명현(t=2.0962,P＜0.05).관찰조치료후6、12개월황반중심요시망막후도변화비대조조경명현(t=5.7206,3.6258,P＜0.05).결론 재치료당뇨병성황반수종중,뢰주단항파리체강내주사연합격광원기효과우우곡안내덕파리체강내주사연합격광치료.
Objective To compare the effect of intravitreal injection of ranibizumab combined with laser and intravitreal injection of triamcinolone acetonide combined with laser on diabetic macular edema.Methods Eighty-four cases(90 eyes) with diabetic macular edema were randomly divided into two groups according to figures.The observation group(42 cases,44 eyes) were operated through intravitreal injection of ranibizumab combined with laser and the control group(44 cases,46 eyes) were operated through intravitreal injection of triamcinolone acetonide combined with laser.To detect the visual acuity,fundus,fundus fluorescein angiography and macular thickness 1,3,6,12 months after treatment.Results 1,3,6,12 months after treatment,the effective rates were 70.5％,79.6％,76.2％,70.7％ in the observation group and 69.6％,80.4％,69.4％,60.0％ in the control group.There were no significant difference between the two groups 1,3months after treatment(t =0.7246,0.3094,P ＞ 0.05),the effective rates in the observation group were significantly higher than that in control group 6,12 month after treatment (t =3.7068,5.7728,P ＜ 0.05).Twelve months after treatment,the vision changes in the observation group was significantly better than the control group (t =2.0962,P ＜ 0.05).And 6,12 months after the treatment,foveal retinal thickness changes in the observation group were improved significantly than that in the control group (t =5.7206,3.6258,P ＜ 0.05).Conclusions In the treatment of diabetic macular edema,long-term effect through intravitreal injection of ranibizumab combined with laser was improved significantly than intravitreal injection of triamcinolone acetonide combined with laser.
