CAJ | 학술논문

毒力因子是在病原体适应生存环境的过程中产生.烟曲霉毒力是多因素相关的,包括微小的孢子结构使之能够吸入到达宿主的肺泡,耐热特征,疏水性,快速的繁殖速度以及抵抗氧化应激反应的能力.此外,烟曲霉适应环境及代谢相关的蛋白、通路信号分子、脂类代谢产物、毒素等均可看作毒力因子.
독력인자시재병원체괄응생존배경적과정중산생.연곡매독력시다인소상관적,포괄미소적포자결구사지능구흡입도체숙주적폐포,내열특정,소수성,쾌속적번식속도이급저항양화응격반응적능력.차외,연곡매괄응배경급대사상관적단백、통로신호분자、지류대사산물、독소등균가간작독력인자.
Virulence factors are produced in the process of pathogen adapting to stress in the microenvironment.It is demonstrated that the virulence of Aspergillus fumigatus is multifactorial.Some of these characteristics include the small size of its conidia which allows them to reach the human pulmonary alveoli,its thermotolerance,hydrophobicity and its high growth rate,and resistance to oxidative stress.In addition,the proteins required for adaptation to the environment and metabolism,the channel signal molecule,lipid metabolites,and toxins are seen as virulence factors.