CAJ | 학술논문

目的研究厦门地区人群全血糖化血红蛋白(HbA1c)水平的分布情况,以探讨该地区人群HbA1c与性别、年龄之间的关系.方法横断面调查.收集2013年1月至2014年4月在厦门大学附属中山医院体检的10 487份样本,应用日本Arkray HA-8180型全自动糖化血红蛋白分析仪检测HbA1c,分析不同性别和年龄组之间HbA1c水平的差异,探索HbA1c与年龄之间的规律,比较采用不同的糖尿病(DM)诊断标准的情况.两组间比较采用Independent-Samples T Test,多组间比较先采用单因素方差分析(One-way ANOVA),组间两两比较采用LSD-T检验.不同变量间的相关分析采用Pearson相关分析及线性回归.结果 10 487例体检者以及其中9 436例HbA1c＜6.5％的体检者的HbA1c与年龄均呈正相关,线性回归方程分别为HbA1c(％)=0.021 2×年龄(岁)+4.811 9(r=0.348 9,P=0.000)和HbA1c(％)=0.010 9×年龄(岁)+5.094 4(r =0.425 7,P=0.000);HbA1c在男、女之间的差异具有统计学意义(P＜0.001)且男性的总体水平高于女性;不同性别人群的HbA1c水平均呈现出随年龄增大而逐渐增高的趋势;依据2010年美国糖尿病协会(ADA)标准,糖尿病高危人群占39.60％,比以国际专家委员会标准识别出的高危人群比例高出2.55倍.结论厦门地区HbA1c水平与年龄、性别均有关,提示有必要建立不同的参考区间和DM诊断切点.采用2010年ADA标准可识别出更多的DM高危人群,尤其适合在体检筛查中的应用.
목적 연구하문지구인군전혈당화혈홍단백(HbA1c)수평적분포정황,이탐토해지구인군HbA1c여성별、년령지간적관계.방법 횡단면조사.수집2013년1월지2014년4월재하문대학부속중산의원체검적10 487빈양본,응용일본Arkray HA-8180형전자동당화혈홍단백분석의검측HbA1c,분석불동성별화년령조지간HbA1c수평적차이,탐색HbA1c여년령지간적규률,비교채용불동적당뇨병(DM)진단표준적정황.량조간비교채용Independent-Samples T Test,다조간비교선채용단인소방차분석(One-way ANOVA),조간량량비교채용LSD-T검험.불동변량간적상관분석채용Pearson상관분석급선성회귀.결과 10 487례체검자이급기중9 436례HbA1c＜6.5％적체검자적HbA1c여년령균정정상관,선성회귀방정분별위HbA1c(％)=0.021 2×년령(세)+4.811 9(r=0.348 9,P=0.000)화HbA1c(％)=0.010 9×년령(세)+5.094 4(r =0.425 7,P=0.000);HbA1c재남、녀지간적차이구유통계학의의(P＜0.001)차남성적총체수평고우녀성;불동성별인군적HbA1c수평균정현출수년령증대이축점증고적추세;의거2010년미국당뇨병협회(ADA)표준,당뇨병고위인군점39.60％,비이국제전가위원회표준식별출적고위인군비례고출2.55배.결론 하문지구HbA1c수평여년령、성별균유관,제시유필요건립불동적삼고구간화DM진단절점.채용2010년ADA표준가식별출경다적DM고위인군,우기괄합재체검사사중적응용.
Objective To study the distribution of glycosylated hemoglobin A1c (HbA1c) levels in Xiamen,and to investigate the relationship among HbA1c level and gender and age.Methods This was a cross-sectional study.10 487 cases of physical examination individuals in Zhongshan hospital from January 2013 to April 2014 were recruited.HbA1c was measured by ARKRAY HA-8180 automatic glycosylated hemoglobin analyzer (Japan).All data were collected for analyzing the HbA1c levels in different sex and age groups,exploring the rule between HbA1c and age,and comparing the different diagnostic criteria of diabetes mellitus(DM).Differences between the two groups were compared using the Independent Samples T Test.The measurement data of multiple group were compared with single factor analysis of variance (One way ANOVA),and the comparison between two groups was performed with LSD T test.Correlation between different variables was analyzed by Pearson correlation and linear regression.Results Focused on all the 10 487 cases and 9 436 cases with HbA1c ＜ 6.5％ physical examination population,the levels of HbA1c were positively correlated with age,the linear regression equations were HbA1c (％) =0.021 2 × age (years) + 4.811 9 (r =0.348 9,P=0.000) and HbA1c(％) =0.010 9 × age (years) + 5.0944 (r=0.4257,P =0.000)respectively; HbA1c levels in male physical examination population were significantly higher than those in females (P ＜ 0.001),moreover,in different gender groups,HbA1c level had gradually risen with increasing age.Patients at risk for diabetes (prediabetes,39.60％) diagnosed by the criteria of 2010 American Diabetes Association (ADA) were 2.55 times more than those diagnosed by the criteria of international expert committee (15.55％).Conclusions The HbA1c level is related to age and gender in Xiamen city.It is necessary to establish different reference intervals and DM diagnostic cut-off point.The criteria of 2010 ADA can identify more high-risk DM individuals,with is especially suitable for the physical examination screening.