CAJ | 학술논문

目的探讨新诊2型糖尿病患者糖化血红蛋白(HbA1c)水平与颈动脉内中膜厚度(CIMT)的相关性.方法病例对照研究.选取南京市鼓楼医院2013年1月至2014年2月确诊的159例新诊2型糖尿病患者,按HbA1c数值分为A组(HbA1c≤7.0％,n=44),B组(7.0％＜HbA1c≤9.0％,n =58)和C组(HbA1c＞9.0％,n=57).检测新诊2型糖尿病患者糖化血红蛋白、血脂水平,并对患者进行颈动脉超声检查.采用Pearson直线相关对HbA1c与各指标的相关性进行分析;采用单因素方差检验分析三组间的临床资料.同时采用logistic回归分析进行统计学分析.结果单因素方差分析显示,C组右CIMT、左CIMT、平均CIMT和最大CIMT水平高于B组和A组,差异有统计学意义.Logistic逐步回归分析显示年龄和HbA1c是最大CIMT的危险因素[年龄,风险比(OR)=1.103,95％置信区间(CI)=1.038 ～1.173,P＜0.05;HbA1c,OR =2.531,95％ CI=1.558～4.111,P＜0.05].结论新诊2型糖尿病患者中,HbA1c水平与CIMT显著相关,HbA1c是最大CIMT增厚的独立危险因素,HbA1c水平升高与最大CIMT增厚显著相关.
목적 탐토신진2형당뇨병환자당화혈홍단백(HbA1c)수평여경동맥내중막후도(CIMT)적상관성.방법 병례대조연구.선취남경시고루의원2013년1월지2014년2월학진적159례신진2형당뇨병환자,안HbA1c수치분위A조(HbA1c≤7.0％,n=44),B조(7.0％＜HbA1c≤9.0％,n =58)화C조(HbA1c＞9.0％,n=57).검측신진2형당뇨병환자당화혈홍단백、혈지수평,병대환자진행경동맥초성검사.채용Pearson직선상관대HbA1c여각지표적상관성진행분석;채용단인소방차검험분석삼조간적림상자료.동시채용logistic회귀분석진행통계학분석.결과 단인소방차분석현시,C조우CIMT、좌CIMT、평균CIMT화최대CIMT수평고우B조화A조,차이유통계학의의.Logistic축보회귀분석현시년령화HbA1c시최대CIMT적위험인소[년령,풍험비(OR)=1.103,95％치신구간(CI)=1.038 ～1.173,P＜0.05;HbA1c,OR =2.531,95％ CI=1.558～4.111,P＜0.05].결론 신진2형당뇨병환자중,HbA1c수평여CIMT현저상관,HbA1c시최대CIMT증후적독립위험인소,HbA1c수평승고여최대CIMT증후현저상관.
Objective To examine the relationship between glycated hemoglobin (HbA1c and carotid intima-media thickness (CIMT) in newly diagnosed 2 diabetes patients.Methods A total of 159 newly diagnosed type 2 diabetes patients visiting the Drum Tower Hospital,Nanjing,were collected from January 2013 to February 2014.All patients were divided into A group (HbA1c ≤7.0％,n =44),B group (7.0％＜ HbA1c≤9.0％,n=58) and C group (HbA1c＞9.0％,n=57) HbA1c,triacylglycerol (TG),total cholesterol (TC),high density lipoprotein cholesterol-C (HDL-C),low density lipoprotein cholesterol-C (LDL-C),lipoprotein A I (APOA I) and lipoprotein B (APOB).CIMT and the presence of carotid plaques were determined using ultrasonography.Pearson's correlation test was performed to examine various correlations.The effect of glycaemic control on various parameters was evaluated by one-way analysis of variance.Logistic regression analysis was used for statistical analysis.Results C group demonstrated significantly higher left CIMT,right CIMT,average CIMT and maximal CIMT levels as compared to A group and B group.Logistic stepwise regression analysis indicated that the independent factors of maximal CIMT were age and HbA1c [age,odds ratio (OR) =1.103,95％ confidence interval (CI):1.038-1.173,P ＜ 0.05; HbA1c,OR=2.531,95％CI:1.558-4.111,P＜0.05].Conclusion HbA1c was significantly associated with CIMT in newly diagnosed diabetes patients.This study indicated that HbA1c might be an independent factor of elevated maximal CIMT in newly diagnosed type 2 diabetes patients.