中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2015年
1期
51-54
,共4页
董媛%张钰%夏英杰%王兵%陈跃国
董媛%張鈺%夏英傑%王兵%陳躍國
동원%장옥%하영걸%왕병%진약국
二苯甲酮类%溴化苯类%眼药水%角膜切削术,上皮下,激光%疼痛%眼表现
二苯甲酮類%溴化苯類%眼藥水%角膜切削術,上皮下,激光%疼痛%眼錶現
이분갑동류%추화분류%안약수%각막절삭술,상피하,격광%동통%안표현
Benzophenones%Bromobenzenes%Ophthalmic solutions%Keratectomy,subepithelial,laser-assisted%Pain%Eye manifestations
目的 探讨0.1％溴芬酸钠水合物滴眼液对减轻准分子激光角膜上皮瓣下磨镶术(LASEK)后眼部刺激症状的疗效.方法 前瞻性随机对照研究.将接受LASEK治疗的屈光不正患者64例随机分为两组,每组选取右眼入组观察,溴芬酸钠组在术前3d及术后1d给予0.1％溴芬酸钠水合物滴眼液2次/d,对照组在术前3d及术后1d给予0.5％酮咯酸氨丁三醇滴眼液4次/d,在术后1、3、5、7d观察眼部刺激症状分级、持续时间、角膜上皮愈合时间以及裸眼视力,对符合正态分布的计量资料组间比较采用￡检验,非正态分布的计量资料比较采用秩和检验,计数资料的比较采用x2检验,重复测量资料采用重复测量设计的方差分析.结果 溴芬酸钠组患者滴用0.1％溴芬酸钠水合物滴眼液眼部无任何不适,对照组患者滴用0.5％酮咯酸氨丁三醇滴眼液,87.5％眼部有刺痛、烧灼感等不适,持续时间2～3s.溴芬酸钠组患者术后眼部刺激症状0、1、2级的比例分别为31.2％(10/32)、68.8％(22/32)、0.0％ (0/32),与对照组相比差异无统计学意义(Z=-1.625,P=0.104);溴芬酸钠组术后刺激症状持续时间中位数为2.00d,较对照组缩短(Z=-2.895,P=0.004);溴芬酸钠组与对照组术后角膜上皮愈合时间中位数均为5.00d,差异无统计学意义(Z=-1.723,P=0.085),两组术后1d、3d、5d、1个月、3个月裸眼视力差异均无统计学意义(F=2.086,2.180,2.869,0.143,0.401;P＞0.05).结论 0.1％溴芬酸钠滴眼液能有效缓解LASEK术后眼部刺激症状,患者的耐受性与使用便利性比0.5％酮咯酸氨丁三醇滴眼液更好.
目的 探討0.1％溴芬痠鈉水閤物滴眼液對減輕準分子激光角膜上皮瓣下磨鑲術(LASEK)後眼部刺激癥狀的療效.方法 前瞻性隨機對照研究.將接受LASEK治療的屈光不正患者64例隨機分為兩組,每組選取右眼入組觀察,溴芬痠鈉組在術前3d及術後1d給予0.1％溴芬痠鈉水閤物滴眼液2次/d,對照組在術前3d及術後1d給予0.5％酮咯痠氨丁三醇滴眼液4次/d,在術後1、3、5、7d觀察眼部刺激癥狀分級、持續時間、角膜上皮愈閤時間以及裸眼視力,對符閤正態分佈的計量資料組間比較採用￡檢驗,非正態分佈的計量資料比較採用秩和檢驗,計數資料的比較採用x2檢驗,重複測量資料採用重複測量設計的方差分析.結果 溴芬痠鈉組患者滴用0.1％溴芬痠鈉水閤物滴眼液眼部無任何不適,對照組患者滴用0.5％酮咯痠氨丁三醇滴眼液,87.5％眼部有刺痛、燒灼感等不適,持續時間2～3s.溴芬痠鈉組患者術後眼部刺激癥狀0、1、2級的比例分彆為31.2％(10/32)、68.8％(22/32)、0.0％ (0/32),與對照組相比差異無統計學意義(Z=-1.625,P=0.104);溴芬痠鈉組術後刺激癥狀持續時間中位數為2.00d,較對照組縮短(Z=-2.895,P=0.004);溴芬痠鈉組與對照組術後角膜上皮愈閤時間中位數均為5.00d,差異無統計學意義(Z=-1.723,P=0.085),兩組術後1d、3d、5d、1箇月、3箇月裸眼視力差異均無統計學意義(F=2.086,2.180,2.869,0.143,0.401;P＞0.05).結論 0.1％溴芬痠鈉滴眼液能有效緩解LASEK術後眼部刺激癥狀,患者的耐受性與使用便利性比0.5％酮咯痠氨丁三醇滴眼液更好.
목적 탐토0.1％추분산납수합물적안액대감경준분자격광각막상피판하마양술(LASEK)후안부자격증상적료효.방법 전첨성수궤대조연구.장접수LASEK치료적굴광불정환자64례수궤분위량조,매조선취우안입조관찰,추분산납조재술전3d급술후1d급여0.1％추분산납수합물적안액2차/d,대조조재술전3d급술후1d급여0.5％동각산안정삼순적안액4차/d,재술후1、3、5、7d관찰안부자격증상분급、지속시간、각막상피유합시간이급라안시력,대부합정태분포적계량자료조간비교채용￡검험,비정태분포적계량자료비교채용질화검험,계수자료적비교채용x2검험,중복측량자료채용중복측량설계적방차분석.결과 추분산납조환자적용0.1％추분산납수합물적안액안부무임하불괄,대조조환자적용0.5％동각산안정삼순적안액,87.5％안부유자통、소작감등불괄,지속시간2～3s.추분산납조환자술후안부자격증상0、1、2급적비례분별위31.2％(10/32)、68.8％(22/32)、0.0％ (0/32),여대조조상비차이무통계학의의(Z=-1.625,P=0.104);추분산납조술후자격증상지속시간중위수위2.00d,교대조조축단(Z=-2.895,P=0.004);추분산납조여대조조술후각막상피유합시간중위수균위5.00d,차이무통계학의의(Z=-1.723,P=0.085),량조술후1d、3d、5d、1개월、3개월라안시력차이균무통계학의의(F=2.086,2.180,2.869,0.143,0.401;P＞0.05).결론 0.1％추분산납적안액능유효완해LASEK술후안부자격증상,환자적내수성여사용편리성비0.5％동각산안정삼순적안액경호.
Objective To observe the efficacy of bromfenac sodium eye drops on relieving the irritative symptoms after LASEK surgery.Methods Sixty-four people who had received LASEK surgery were randomly divided into two groups,observing the right eye for each group,group A was given 0.1％ bromfenac sodium eye drops twice a day in three days before surgery and one day after surgery; group B was given 0.5％ ketorolac tromethamine (acular) eye drops four times a day in three days before surgery and on day after surgery.In the 1st,rd,5th and 7th day after surgery,irritative symptoms grade,duration of irritation,time for corneal epithelial healing,and uncorrected visual acuity were observed and compared between the two groups.Results 0.1％ no discomfort in group A with bromfenac sodium eye drops was observed while 0.5％ ketorolac tromethamine eye drops caused tingling,burning discomfort that lasted for 2-3 seconds in 16 of the 28 subjects (87.5％).No significant difference was observed between the irritation grades of group A and B (Z =-1.625,P =0.104) ; the duration of irritative symptom was significantly shorter in group A than that in group B (Z =-2.895,P =0.004).No significant difference was observed between the time of healing and visual acuity recovery of the two groups.Conclusion 0.1％ bromfenac sodium eye drops can effectively relieve the post-LASEK irritative symptoms,and it is better tolerated than 0.5％ ketorolac tromethamine eye drops.
