CAJ | 학술논문

目的探讨Eph受体酪氨酸激酶A2(EphA2)和CD133在胃癌组织中的表达及其与临床病理特征和预后关系.方法采用免疫组织化学法检测82例胃癌患者手术切除的癌组织和癌旁组织中EphA2和CD133表达水平.结果 EphA2在胃癌组织中的表达率明显高于癌旁组织(86.59％比20.73％,P＜0.01),CD133在胃癌组织中的表达率明显高于癌旁组织(67.07％比10.98％,P＜0.01);EphA2表达水平与胃癌TNM分期、淋巴结转移明显相关(P＜0.05),CD133表达水平与胃癌组织学分化程度、TNM分期、淋巴结转移明显相关(P＜0.05).结论 EphA2和CD133过度表达可能在胃癌的发生、发展过程中发挥作用.
목적 탐토Eph수체락안산격매A2(EphA2)화CD133재위암조직중적표체급기여림상병리특정화예후관계.방법 채용면역조직화학법검측82례위암환자수술절제적암조직화암방조직중EphA2화CD133표체수평.결과 EphA2재위암조직중적표체솔명현고우암방조직(86.59％비20.73％,P＜0.01),CD133재위암조직중적표체솔명현고우암방조직(67.07％비10.98％,P＜0.01);EphA2표체수평여위암TNM분기、림파결전이명현상관(P＜0.05),CD133표체수평여위암조직학분화정도、TNM분기、림파결전이명현상관(P＜0.05).결론 EphA2화CD133과도표체가능재위암적발생、발전과정중발휘작용.
Objective To analyze the expression of erythropoietin producing human hepatocellular receptor A2 (EphA2) and CD133 in gastric carcinoma and their relationship with clinicopathological features and the prognosis of gastric carcinoma.Methods Envision immunohistochemical method was used to assess the expression of EphA2 and CD133 in 82 cases of human gastric carcinoma tissues and non-cancerous adjacent gastric tissues.Results The expression rate of EphA2 in gastric carcinoma tissues was higher than that in non-cancerous adjacent gastric tissues (86.59％ vs.20.73％,P ＜ 0.01).The expression rate of CD133 in gastric carcinoma tissues was higher than that in non-cancerous adjacent gastric tissues (67.07％ vs.10.98％,P ＜0.01).The expression of EphA2 was related to TNM stage and lymph node metastasis of gastric carcinoma (P ＜ 0.05).There was a close correlation between the expression of CD133 and histological grade,TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion The overexpression of EphA2 and CD133 may play certain roles in the pathogenesis of gastric carcinoma.