CAJ | 학술논문

目的探讨膜联蛋白A2(Annexin A2)和锌指转录因子Snail在胶质瘤组织的表达水平及两者与胶质瘤病理学特征的关系.方法应用免疫组织化学法检测52例胶质瘤组织和22例正常脑组织中Annexin A2和Snail表达水平.结果 Annexin A2在胶质瘤组织中阳性表达率明显高于正常脑组织(80.77％比9.09％,P＜0.01),Snail在胶质瘤组织中阳性表达率明显高于正常脑组织(67.31％比13.64％,P＜0.01);Annexin A2及Snail表达水平与胶质瘤组织学分级有关(P＜0.05).结论 Annexin A2及Snail的过度表达与胶质瘤的发生发展和恶性程度有关,联合检测Annexin A2及Snail有助于判断胶质瘤患者预后.
목적 탐토막련단백A2(Annexin A2)화자지전록인자Snail재효질류조직적표체수평급량자여효질류병이학특정적관계.방법 응용면역조직화학법검측52례효질류조직화22례정상뇌조직중Annexin A2화Snail표체수평.결과 Annexin A2재효질류조직중양성표체솔명현고우정상뇌조직(80.77％비9.09％,P＜0.01),Snail재효질류조직중양성표체솔명현고우정상뇌조직(67.31％비13.64％,P＜0.01);Annexin A2급Snail표체수평여효질류조직학분급유관(P＜0.05).결론 Annexin A2급Snail적과도표체여효질류적발생발전화악성정도유관,연합검측Annexin A2급Snail유조우판단효질류환자예후.
Objective To investigate the expression of Annexin A2 and Snail and their relation to pathological features in human brain glioma.Methods The expression levels of Annexin A2 and Snail in 52 cases of human brain glioma tissues and 22 cases of normal brain tissues were detected by using immunohistochemical method.Results The expression rate of Annexin A2 in brain glioma tissues was higher than that of normal brain tissues (80.77％ vs.9.09％,P ＜ 0.01).The expression rate of Snail in in brain glioma tissues was higher than that of normal brain tissues (67.31％ vs.13.64％,P ＜0.01).The expression levels of Annexin A2 and Snail were related to histological grades of brain glioma (P ＜ 0.05).Conclusion The over-expression of Annexin A2 and Snail might be correlated with the onset,progression and the malignant degree of brain glioma.Combined detection of Annexin A2 and Snail could be one helpful index in the prognostic judgment of brain glioma.