中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2015年
1期
31-34
,共4页
李小宝%梅乐园%刘斌%白铁成%李晓勇%刘勇峰%白忠学%高峰%车向明
李小寶%梅樂園%劉斌%白鐵成%李曉勇%劉勇峰%白忠學%高峰%車嚮明
리소보%매악완%류빈%백철성%리효용%류용봉%백충학%고봉%차향명
胃肿瘤%淋巴转移%肿瘤分期%预后
胃腫瘤%淋巴轉移%腫瘤分期%預後
위종류%림파전이%종류분기%예후
Stomach neoplasms%Lymphatic metastasis%Neoplasm staging%Prognosis
目的 探讨淋巴结转移率(metastatic lymph nodes ratio,MLR)对各pT分期胃癌患者预后的评估价值.方法 回顾性分析535例接受手术治疗胃癌患者的临床资料,将MLR与UICC/AJCC pN分期对胃癌患者预后的评价价值进行比较,确定MLR分期方法的特点及优势.分层分析MLR对各个pT分期胃癌患者预后的评价价值.结果 单因素生存分析方法将MLR分为4期:MLR0(0)、MLR1(1% ~9%)、MLR2(10% ~ 20%)、MLR3(>20%),各期患者的5年生存率分别为69.7%、63.5%、31.7%、28.6%,差异有统计学意义(P<0.01),MLR分期越高预后越差.单因素Kaplan-Meier法生存分析显示,MLR与患者预后密切相关;多因素COX比例风险回归模型分析显示,MLR是胃癌患者预后的主要独立危险因素.MLR预测胃癌患者术后5年死亡与否的ROC曲线下面积与pN分期相比差异无统计学意义.MLR对pT2和pT3期胃癌预后有较好的评估价值,差异有统计学意义(P<0.05).结论 MLR是胃癌预后的独立因素,预测胃癌患者预后的准确性较pN分期系统更为可靠,特别是对pT2-pT3期胃癌患者的预后有较好的评估价值.
目的 探討淋巴結轉移率(metastatic lymph nodes ratio,MLR)對各pT分期胃癌患者預後的評估價值.方法 迴顧性分析535例接受手術治療胃癌患者的臨床資料,將MLR與UICC/AJCC pN分期對胃癌患者預後的評價價值進行比較,確定MLR分期方法的特點及優勢.分層分析MLR對各箇pT分期胃癌患者預後的評價價值.結果 單因素生存分析方法將MLR分為4期:MLR0(0)、MLR1(1% ~9%)、MLR2(10% ~ 20%)、MLR3(>20%),各期患者的5年生存率分彆為69.7%、63.5%、31.7%、28.6%,差異有統計學意義(P<0.01),MLR分期越高預後越差.單因素Kaplan-Meier法生存分析顯示,MLR與患者預後密切相關;多因素COX比例風險迴歸模型分析顯示,MLR是胃癌患者預後的主要獨立危險因素.MLR預測胃癌患者術後5年死亡與否的ROC麯線下麵積與pN分期相比差異無統計學意義.MLR對pT2和pT3期胃癌預後有較好的評估價值,差異有統計學意義(P<0.05).結論 MLR是胃癌預後的獨立因素,預測胃癌患者預後的準確性較pN分期繫統更為可靠,特彆是對pT2-pT3期胃癌患者的預後有較好的評估價值.
목적 탐토림파결전이솔(metastatic lymph nodes ratio,MLR)대각pT분기위암환자예후적평고개치.방법 회고성분석535례접수수술치료위암환자적림상자료,장MLR여UICC/AJCC pN분기대위암환자예후적평개개치진행비교,학정MLR분기방법적특점급우세.분층분석MLR대각개pT분기위암환자예후적평개개치.결과 단인소생존분석방법장MLR분위4기:MLR0(0)、MLR1(1% ~9%)、MLR2(10% ~ 20%)、MLR3(>20%),각기환자적5년생존솔분별위69.7%、63.5%、31.7%、28.6%,차이유통계학의의(P<0.01),MLR분기월고예후월차.단인소Kaplan-Meier법생존분석현시,MLR여환자예후밀절상관;다인소COX비례풍험회귀모형분석현시,MLR시위암환자예후적주요독립위험인소.MLR예측위암환자술후5년사망여부적ROC곡선하면적여pN분기상비차이무통계학의의.MLR대pT2화pT3기위암예후유교호적평고개치,차이유통계학의의(P<0.05).결론 MLR시위암예후적독립인소,예측위암환자예후적준학성교pN분기계통경위가고,특별시대pT2-pT3기위암환자적예후유교호적평고개치.
Objective To evaluate the prognostic value of metastatic lymph node ration (MLR) in gastric cancer patients by T stage.Methods Clinical data of 535 patients with gastric cancer undergoing radical gastrectomy and lymphadenectomy were reviewed.MLR classification was compared with pN classification in terms of the accuracy and valid value.The MLR in T stage patients were analyzed retrospectively.Results The MLR was assessed in 4 categories:0,0.01-0.09,0.1-0.2,> 0.2.Kaplan-Meier survival analysis showed that MLR significantly influenced the postoperative survival time and Cox proportional hazard regression model analysis showed MLR was an independent poor prognostic factor.There was no significant difference between the area under the receiver working characteristic curve of MLR and metastatic lymph nodes number in predicting patients 5 year death postoperatively.Conclusions MLR is an independent prognostic factor of patients with gastric cancer.MLR is more reliable factor in predicting the prognosis of gastric cancer patients than the number of metastatic lymph nodes,especially for T2-T3 stage gastric cancer patients.