CAJ | 학술논문

目的探讨视网膜血管直径与家族性高胆固醇血症(FH)的相关性.方法选取2008年6月至2014年2月于首都医科大学附属北京安贞医院确诊为FH的21例患者为FH组,另外选取38例年龄、性别、血压和血糖相匹配的非FH正常者为对照组.通过彩色眼底照相及计算机辅助软件对视网膜动脉直径(CRAE)、视网膜静脉直径(CRVE)和视网膜动、静脉直径比值(AVR)分别进行测量.比较2组患者视网膜血管直径的测量值,并采用多元线性回归分析视网膜血管直径与FH的相关性.结果 2组患者性别、收缩压、舒张压、空腹血糖比较,差异无统计学意义(P＞0.05).与对照组比较,FH组CRAE和AVR数值均明显降低[CRAE:(147 ±6)μm比(150±4)μm,AVR∶(0.65±0.05)比(0.69±0.08)],差异有统计学意义(P＜0.05).2组患者的CRVE比较,差异无统计学意义(P=0.90).校正年龄及性别后,AVR减小与FH相关(P =0.03),FH越明显,AVR越小.结论 FH患者的AVR较正常人群减小,视网膜血管直径改变对FH具有一定提示作用.
목적 탐토시망막혈관직경여가족성고담고순혈증(FH)적상관성.방법 선취2008년6월지2014년2월우수도의과대학부속북경안정의원학진위FH적21례환자위FH조,령외선취38례년령、성별、혈압화혈당상필배적비FH정상자위대조조.통과채색안저조상급계산궤보조연건대시망막동맥직경(CRAE)、시망막정맥직경(CRVE)화시망막동、정맥직경비치(AVR)분별진행측량.비교2조환자시망막혈관직경적측량치,병채용다원선성회귀분석시망막혈관직경여FH적상관성.결과 2조환자성별、수축압、서장압、공복혈당비교,차이무통계학의의(P＞0.05).여대조조비교,FH조CRAE화AVR수치균명현강저[CRAE:(147 ±6)μm비(150±4)μm,AVR∶(0.65±0.05)비(0.69±0.08)],차이유통계학의의(P＜0.05).2조환자적CRVE비교,차이무통계학의의(P=0.90).교정년령급성별후,AVR감소여FH상관(P =0.03),FH월명현,AVR월소.결론 FH환자적AVR교정상인군감소,시망막혈관직경개변대FH구유일정제시작용.
Objective To examine the relation between retinal vascular caliber and familial hypercholesterolemia (FH).Methods We prospectively recruited 21 cases of FH and 38 control cases with matched age,gender,blood pressure and blood sugar from June 2008 to February 2014.Central retinal artery equivalent (CRAE),central retinal vein equivalent (CRVE) and arteriovenous ratio (AVR) were assessed from baseline retinal photographs using IVAN software.CRAE,CRVE and AVR were compared with the student t test between FH group and controls.Multiple linear regression analysis was performed to evaluate the correlation between retinal vascular caliber and FH.Results CRAE and AVR were decreased in FH group compared with controls[CRAE:(147 ± 6) μm vs (150 ± 4) μm,AVR:(0.65 ± 0.05) vs (0.69 ± 0.08)].The difference between the two groups was significant (P ＜ 0.05).Decreased AVR was associated with FH (P =0.03) after controlling age and sex.Conclusions AVR is effective for patients with FH.The variation of retinal vascular caliber may be useful in the prediction of FH.