中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
2期
150-152
,共3页
急性冠状动脉综合征%冠状动脉疾病%基质金属蛋白酶9%相关性
急性冠狀動脈綜閤徵%冠狀動脈疾病%基質金屬蛋白酶9%相關性
급성관상동맥종합정%관상동맥질병%기질금속단백매9%상관성
Acute coronary syndrome%Coronary artery disease%Matrix metalloproteinase-9%Correlation
目的 探讨急性冠状动脉综合征(ACS)患者冠状动脉病变程度与血清基质金属蛋白酶9(M MP-9)表达的相关性.方法 选择2011年8月到2013年12月在湖北医药学院附属东风医院进行诊治的ACS患者80例作为观察组(不稳定型心绞痛45例,急性心肌梗死35例),选择同期无ACS的80例患者作为对照组,对2组临床一般资料、血液生化与血清MMP-9表达进行回顾性分析.结果 观察组血清MMP-9含量明显高于对照组[(125±14) μg/L比(87±14) μg/L,P＜0.05],同时急性心肌梗死患者的血清MMP-9含量明显高于不稳定型心绞痛患者[(146±14) μg/L比(111±14) μg/L,P＜0.05].Logistic回归分析发现MMP-9比值比为1.982,95％置信区间为1.029 ～2.837,P＜0.05;三酰甘油比值比为11.870,95％置信区间为2.819 ～14.822,P＜0.05;总胆固醇比值比为3.782,95％置信区间为1.673 ～ 8.993,P＜0.05.结论 ACS伴随有血清MMP-9含量的增加,并且与冠状动脉病变程度有一定的相关性,MMP-9、冠状动脉病变与脂质因子共同作用能促进ACS的发生.
目的 探討急性冠狀動脈綜閤徵(ACS)患者冠狀動脈病變程度與血清基質金屬蛋白酶9(M MP-9)錶達的相關性.方法 選擇2011年8月到2013年12月在湖北醫藥學院附屬東風醫院進行診治的ACS患者80例作為觀察組(不穩定型心絞痛45例,急性心肌梗死35例),選擇同期無ACS的80例患者作為對照組,對2組臨床一般資料、血液生化與血清MMP-9錶達進行迴顧性分析.結果 觀察組血清MMP-9含量明顯高于對照組[(125±14) μg/L比(87±14) μg/L,P＜0.05],同時急性心肌梗死患者的血清MMP-9含量明顯高于不穩定型心絞痛患者[(146±14) μg/L比(111±14) μg/L,P＜0.05].Logistic迴歸分析髮現MMP-9比值比為1.982,95％置信區間為1.029 ～2.837,P＜0.05;三酰甘油比值比為11.870,95％置信區間為2.819 ～14.822,P＜0.05;總膽固醇比值比為3.782,95％置信區間為1.673 ～ 8.993,P＜0.05.結論 ACS伴隨有血清MMP-9含量的增加,併且與冠狀動脈病變程度有一定的相關性,MMP-9、冠狀動脈病變與脂質因子共同作用能促進ACS的髮生.
목적 탐토급성관상동맥종합정(ACS)환자관상동맥병변정도여혈청기질금속단백매9(M MP-9)표체적상관성.방법 선택2011년8월도2013년12월재호북의약학원부속동풍의원진행진치적ACS환자80례작위관찰조(불은정형심교통45례,급성심기경사35례),선택동기무ACS적80례환자작위대조조,대2조림상일반자료、혈액생화여혈청MMP-9표체진행회고성분석.결과 관찰조혈청MMP-9함량명현고우대조조[(125±14) μg/L비(87±14) μg/L,P＜0.05],동시급성심기경사환자적혈청MMP-9함량명현고우불은정형심교통환자[(146±14) μg/L비(111±14) μg/L,P＜0.05].Logistic회귀분석발현MMP-9비치비위1.982,95％치신구간위1.029 ～2.837,P＜0.05;삼선감유비치비위11.870,95％치신구간위2.819 ～14.822,P＜0.05;총담고순비치비위3.782,95％치신구간위1.673 ～ 8.993,P＜0.05.결론 ACS반수유혈청MMP-9함량적증가,병차여관상동맥병변정도유일정적상관성,MMP-9、관상동맥병변여지질인자공동작용능촉진ACS적발생.
Objective To investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression and coronary artery disease in acute coronary syndrome(ACS) patients.Methods Totally 80 acute coronary syndrome patients from August 2011 to December 2013 in Hubei Medical College Affiliated Dongfeng Hospital were selected for the observation group (45 cases of unstable angina,35 cases of acute myocardial infarction),80 no-acute coronary syndrome patients were selected for the control group.The clinical data and biochemical data of two groups were analyzed retrospectively.Results The serum MMP-9 values in observation group was significantly higher than that in control group [(125 ± 14) μg/L vs (87 ± 14) μg/L,P ＜0.05],at the same time the serum MMP-9 values in patients with acute myocardial infarction were significantly higher than those in patients with stable angina [(146 ± 14) μg/L vs (111 ± 14) μg/L,P ＜0.05].Multivariate logistic regression analysis showed that the odds ratio of matrix MMP-9 was 1.982,the 95％ CI were 1.029-2.837,P ＜0.05 ; odds ratio of triglyceride was 11.870,95％ CI were 2.819-14.822,P ＜0.05 ; the odds ratio of total cholesterol was 3.782,the 95％ CI were 1.673-8.993,P ＜0.05.Conclusion ACS is associated with increased MMP-9 which is also correlated with severity of coronary artery disease.
