中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
2期
172-176
,共5页
许淑文%李艳%郑红云%戴雯
許淑文%李豔%鄭紅雲%戴雯
허숙문%리염%정홍운%대문
沙美特罗替卡松%孟鲁司特%哮喘
沙美特囉替卡鬆%孟魯司特%哮喘
사미특라체잡송%맹로사특%효천
Salmeterol fluticasone%Montelukast%Asthma
目的 评价沙美特罗替卡松联合孟鲁司特治疗儿童哮喘的疗效.方法 采用计算机检索和手工检索相结合的方法搜索PubMed、Cochrane Library、EMbase、中国期刊全文数据库、中国生物医学文献数据库、维普中文科技期刊数据库、万方医学数据库,时间为从建库至2013年3月.收集沙美特罗替卡松联合孟鲁司特和单用沙美特罗替卡松治疗儿童哮喘的随机对照试验(RCT),对符合纳入标准的研究采用RevMan 5.1软件进行Meta分析.比较沙美特罗替卡松联合孟鲁司特与单用沙美特罗替卡松的疗效.结果 共纳入11篇文献,包括410例沙美特罗替卡松联合孟鲁司特治疗患者和378例单用沙美特罗替卡松治疗患者.Meta分析显示,2组患者治疗后最大峰流量差异有统计学意义[加权均数差(WMD)=6.53,95%置信区间(CI):2.71 ~ 10.36,P <0.01];治疗后第1秒钟用力呼气容积差异有统计学意义(WMD=7.28,95% CI:3.30 ~11.26,P <0.01);哮喘症状评分差异有统计学意义(WMD=-0.25,95% CI:-0.34~-0.17,P <0.01);临床控制率差异有统计学意义[比值比(OR)=1.76,95% CI:1.12 ~2.75,P=0.01];有效率差异有统计学意义(OR=4.32,95% CI:1.63~11.45,P<0.01).结论 孟鲁司特联合沙美特罗替卡松治疗小儿支气管哮喘在疗效方面优于单用沙美特罗替卡松.
目的 評價沙美特囉替卡鬆聯閤孟魯司特治療兒童哮喘的療效.方法 採用計算機檢索和手工檢索相結閤的方法搜索PubMed、Cochrane Library、EMbase、中國期刊全文數據庫、中國生物醫學文獻數據庫、維普中文科技期刊數據庫、萬方醫學數據庫,時間為從建庫至2013年3月.收集沙美特囉替卡鬆聯閤孟魯司特和單用沙美特囉替卡鬆治療兒童哮喘的隨機對照試驗(RCT),對符閤納入標準的研究採用RevMan 5.1軟件進行Meta分析.比較沙美特囉替卡鬆聯閤孟魯司特與單用沙美特囉替卡鬆的療效.結果 共納入11篇文獻,包括410例沙美特囉替卡鬆聯閤孟魯司特治療患者和378例單用沙美特囉替卡鬆治療患者.Meta分析顯示,2組患者治療後最大峰流量差異有統計學意義[加權均數差(WMD)=6.53,95%置信區間(CI):2.71 ~ 10.36,P <0.01];治療後第1秒鐘用力呼氣容積差異有統計學意義(WMD=7.28,95% CI:3.30 ~11.26,P <0.01);哮喘癥狀評分差異有統計學意義(WMD=-0.25,95% CI:-0.34~-0.17,P <0.01);臨床控製率差異有統計學意義[比值比(OR)=1.76,95% CI:1.12 ~2.75,P=0.01];有效率差異有統計學意義(OR=4.32,95% CI:1.63~11.45,P<0.01).結論 孟魯司特聯閤沙美特囉替卡鬆治療小兒支氣管哮喘在療效方麵優于單用沙美特囉替卡鬆.
목적 평개사미특라체잡송연합맹로사특치료인동효천적료효.방법 채용계산궤검색화수공검색상결합적방법수색PubMed、Cochrane Library、EMbase、중국기간전문수거고、중국생물의학문헌수거고、유보중문과기기간수거고、만방의학수거고,시간위종건고지2013년3월.수집사미특라체잡송연합맹로사특화단용사미특라체잡송치료인동효천적수궤대조시험(RCT),대부합납입표준적연구채용RevMan 5.1연건진행Meta분석.비교사미특라체잡송연합맹로사특여단용사미특라체잡송적료효.결과 공납입11편문헌,포괄410례사미특라체잡송연합맹로사특치료환자화378례단용사미특라체잡송치료환자.Meta분석현시,2조환자치료후최대봉류량차이유통계학의의[가권균수차(WMD)=6.53,95%치신구간(CI):2.71 ~ 10.36,P <0.01];치료후제1초종용력호기용적차이유통계학의의(WMD=7.28,95% CI:3.30 ~11.26,P <0.01);효천증상평분차이유통계학의의(WMD=-0.25,95% CI:-0.34~-0.17,P <0.01);림상공제솔차이유통계학의의[비치비(OR)=1.76,95% CI:1.12 ~2.75,P=0.01];유효솔차이유통계학의의(OR=4.32,95% CI:1.63~11.45,P<0.01).결론 맹로사특연합사미특라체잡송치료소인지기관효천재료효방면우우단용사미특라체잡송.
Objective To assess the efficacy of salmeterol fluticasone combined with montelukast in the treatment of asthma in children.Methods Database such as PubMed,Cochrane Library,EMbase,China knowledge Resource Integrated Database,CBMdise and Chinese Journal Literature Database were searched.Results Eleven literatures were reviewed including 410 cases receiving salmeterol fluticasone combined with montelukast and 378 cases receiving salmeterol fluticasone alone.Meta analysis revealed that peak expiratory flow [weighted mean difference (WMD) =6.53,95 % confidence interval (CI) (2.71,10.36),P < 0.01],forced expiratory volume in the first second [WMD =7.28,95% CI (3.30,11.26),P < 0.01],symptom score [WMD =-0.25,95 % CI(-0.34,-0.17),P < 0.01],clinical control rate [odds ratio (OR) =1.76,95 % CI (1.12,2.75),P =0.01] and effective rate [OR =4.32,95 % CI(1.63,11.45),P < 0.01] had statistical differences.Conclusion The efficacy of salmeterol fluticasone combined with montelukast is superior to salmeterol fluticasone alone in the treatment of asthma in children.