中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
2期
185-187
,共3页
姜丽杰%于敏%周莹%侯宇%娄伟
薑麗傑%于敏%週瑩%侯宇%婁偉
강려걸%우민%주형%후우%루위
脑白质病变%不同部位%抑郁
腦白質病變%不同部位%抑鬱
뇌백질병변%불동부위%억욱
White matter lesions%Different parts%Depression
目的 探讨急性脑梗死后不同部位的脑白质病变(WML)对抑郁发生的影响.方法 纳入大连市第三人民医院神经内科2012年3月至2013年4月住院的急性脑梗死患者97例,根据有无脑白质病变分为2组,比较2组间汉密尔顿焦虑量表(HAMA)评分及汉密尔顿抑郁量表(HAMD)评分有无差异.对有WML组行改良Scheltens评分,并将改良Scheltens评分与HAMD评分进行直线相关分析,了解额叶、颞叶、顶叶、枕叶、基底节、侧脑室旁及小脑、脑干等不同部位的白质损害程度与抑郁严重程度的相关性.结果 有WML组HAMD评分(10±6)分,HAMA评分(11±4)分,无WML组HAMD评分(6±4)分,HAMA评分(9±3)分,2组之间HAMD及HAMA评分比较差异均有统计学意义(均P＜0.05);有WML组59例患者HAMD评分(10±6)分与改良Scheltens评分总分(4.39±0.49)分及额叶(2.76±0.43)分、枕叶白质(1.61±0.49)分、额部脑室旁白质(2.85±0.36)分,病变呈明显正相关(r=0.395,P=0.002;r=0.438,P =0.001;r =0.247,P=0.005;r =0.385,P=0.003).结论 急性脑梗死后不同部位的WML与抑郁障碍相关,主要以额部白质病变为主,额部白质病变越严重,抑郁程度越重.
目的 探討急性腦梗死後不同部位的腦白質病變(WML)對抑鬱髮生的影響.方法 納入大連市第三人民醫院神經內科2012年3月至2013年4月住院的急性腦梗死患者97例,根據有無腦白質病變分為2組,比較2組間漢密爾頓焦慮量錶(HAMA)評分及漢密爾頓抑鬱量錶(HAMD)評分有無差異.對有WML組行改良Scheltens評分,併將改良Scheltens評分與HAMD評分進行直線相關分析,瞭解額葉、顳葉、頂葉、枕葉、基底節、側腦室徬及小腦、腦榦等不同部位的白質損害程度與抑鬱嚴重程度的相關性.結果 有WML組HAMD評分(10±6)分,HAMA評分(11±4)分,無WML組HAMD評分(6±4)分,HAMA評分(9±3)分,2組之間HAMD及HAMA評分比較差異均有統計學意義(均P＜0.05);有WML組59例患者HAMD評分(10±6)分與改良Scheltens評分總分(4.39±0.49)分及額葉(2.76±0.43)分、枕葉白質(1.61±0.49)分、額部腦室徬白質(2.85±0.36)分,病變呈明顯正相關(r=0.395,P=0.002;r=0.438,P =0.001;r =0.247,P=0.005;r =0.385,P=0.003).結論 急性腦梗死後不同部位的WML與抑鬱障礙相關,主要以額部白質病變為主,額部白質病變越嚴重,抑鬱程度越重.
목적 탐토급성뇌경사후불동부위적뇌백질병변(WML)대억욱발생적영향.방법 납입대련시제삼인민의원신경내과2012년3월지2013년4월주원적급성뇌경사환자97례,근거유무뇌백질병변분위2조,비교2조간한밀이돈초필량표(HAMA)평분급한밀이돈억욱량표(HAMD)평분유무차이.대유WML조행개량Scheltens평분,병장개량Scheltens평분여HAMD평분진행직선상관분석,료해액협、섭협、정협、침협、기저절、측뇌실방급소뇌、뇌간등불동부위적백질손해정도여억욱엄중정도적상관성.결과 유WML조HAMD평분(10±6)분,HAMA평분(11±4)분,무WML조HAMD평분(6±4)분,HAMA평분(9±3)분,2조지간HAMD급HAMA평분비교차이균유통계학의의(균P＜0.05);유WML조59례환자HAMD평분(10±6)분여개량Scheltens평분총분(4.39±0.49)분급액협(2.76±0.43)분、침협백질(1.61±0.49)분、액부뇌실방백질(2.85±0.36)분,병변정명현정상관(r=0.395,P=0.002;r=0.438,P =0.001;r =0.247,P=0.005;r =0.385,P=0.003).결론 급성뇌경사후불동부위적WML여억욱장애상관,주요이액부백질병변위주,액부백질병변월엄중,억욱정도월중.
Objective To evaluate the relationship between white matter lesions(WML) of different parts of brain after acute cerebral infarction and depressive disorder.Methods The clinical data of 97 patients with acute cerebral infarction were analyzed.All patients were divided into 2 groups according to with or without WML.The differences of Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) between 2 groups were analyzed.The WML group was scored using the semiquatitative rating scale of Scheltens Rating Scale(Scheltens).The correlation between the scheltens of lateral ventricle,frontal lobe,parietal lobe,temporal lobe,occipital lobe,basal ganglia,cerebella,brainstem and HAMD were observed.Results In WML group,the scale of HAMD was 10 ±6 and HAMA was 11 ±4.In without WML group,the scale of HAMD was 6 ±4 and HAMA was 9 ±3.There were significant differences of HAMA and HAMD between WML group and without WML group.HAMD was positively correlated with total scores of total Scheltens scales(4.39 ± 0.49),frontal (2.76 ± 0.43),occipital white matter(1.61 ± 0.49) and frontal periventricular hyperintensities (2.85 ± 0.36) (r =0.395,P =0.002;r =0.439,P =0.001 ;r =0.247,P =0.005 ;r =0.385,P =0.003).Conclusion WML of different parts after acute cerebral infarction is positively correlated with depressive disorder,especially in frontal white matter.
