中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
2期
213-215
,共3页
胆汁淤积性肝硬化%中医药%熊去氧胆酸%益气解毒软肝法
膽汁淤積性肝硬化%中醫藥%熊去氧膽痠%益氣解毒軟肝法
담즙어적성간경화%중의약%웅거양담산%익기해독연간법
Primary biliary cirrhosis%Traditional Chinese medicine%Ursodeoxycholic acid%Yiqijieduruangan method
目的 探讨益气解毒软肝法联合熊去氧胆酸治疗胆汁淤积性肝硬化(PBC)的疗效.方法 选取2009年10月至2014年6月承德医学院附属医院诊治的63例PBC患者,完全随机分为观察组(33例)和对照组(30例),根据2组患者的病情均给予对症治疗,其中对照组患者给予熊去氧胆酸胶囊250 mg/次,3次/d,口服;观察组患者在同样方法应用熊去氧胆酸治疗的基础上给予益气解毒软肝法组方之中药水煎剂,每日1剂(400 ml),早晚各1次,每次200 ml.治疗3个月后评价疗效,观察2组患者临床治疗有效率及治疗前后2组患者血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、血清总胆红素、白蛋白、白蛋白/球蛋白比值的变化.结果 经过3个月的治疗后,2组患者均有一定的临床疗效,观察组患者的临床有效率为81.8％ (27/33),明显高于对照组的60.0％ (18/30),差异有统计学意义(P＜0.05);2组患者治疗后ALT、AST和总胆红素均较治疗前明显下降,白蛋白、白蛋白/球蛋白比值均较治疗前上升,差异有统计学意义(P ＜0.05或P＜0.01),且治疗后观察组患者的以上指标变化与对照组比较,差异均有统计学意义[ALT:(31±8)U/L比(44±11)U/L、AST:(29 ±9) U/L比(43±11)U/L、总胆红素:(20±3)μmol/L比(25±3)μmol/L、白蛋白:(34.8±1.8)g/L比(32.9±1.8) g/L、白蛋白/球蛋白比值:(1.6±0.4)比(1.4±0.4)](P＜0.05或P＜0.01).结论 益气解毒软肝法联合熊去氧胆酸可以明显改善肝功能,治疗PBC有较好的临床疗效.
目的 探討益氣解毒軟肝法聯閤熊去氧膽痠治療膽汁淤積性肝硬化(PBC)的療效.方法 選取2009年10月至2014年6月承德醫學院附屬醫院診治的63例PBC患者,完全隨機分為觀察組(33例)和對照組(30例),根據2組患者的病情均給予對癥治療,其中對照組患者給予熊去氧膽痠膠囊250 mg/次,3次/d,口服;觀察組患者在同樣方法應用熊去氧膽痠治療的基礎上給予益氣解毒軟肝法組方之中藥水煎劑,每日1劑(400 ml),早晚各1次,每次200 ml.治療3箇月後評價療效,觀察2組患者臨床治療有效率及治療前後2組患者血清丙氨痠轉氨酶(ALT)、天鼕氨痠轉氨酶(AST)、血清總膽紅素、白蛋白、白蛋白/毬蛋白比值的變化.結果 經過3箇月的治療後,2組患者均有一定的臨床療效,觀察組患者的臨床有效率為81.8％ (27/33),明顯高于對照組的60.0％ (18/30),差異有統計學意義(P＜0.05);2組患者治療後ALT、AST和總膽紅素均較治療前明顯下降,白蛋白、白蛋白/毬蛋白比值均較治療前上升,差異有統計學意義(P ＜0.05或P＜0.01),且治療後觀察組患者的以上指標變化與對照組比較,差異均有統計學意義[ALT:(31±8)U/L比(44±11)U/L、AST:(29 ±9) U/L比(43±11)U/L、總膽紅素:(20±3)μmol/L比(25±3)μmol/L、白蛋白:(34.8±1.8)g/L比(32.9±1.8) g/L、白蛋白/毬蛋白比值:(1.6±0.4)比(1.4±0.4)](P＜0.05或P＜0.01).結論 益氣解毒軟肝法聯閤熊去氧膽痠可以明顯改善肝功能,治療PBC有較好的臨床療效.
목적 탐토익기해독연간법연합웅거양담산치료담즙어적성간경화(PBC)적료효.방법 선취2009년10월지2014년6월승덕의학원부속의원진치적63례PBC환자,완전수궤분위관찰조(33례)화대조조(30례),근거2조환자적병정균급여대증치료,기중대조조환자급여웅거양담산효낭250 mg/차,3차/d,구복;관찰조환자재동양방법응용웅거양담산치료적기출상급여익기해독연간법조방지중약수전제,매일1제(400 ml),조만각1차,매차200 ml.치료3개월후평개료효,관찰2조환자림상치료유효솔급치료전후2조환자혈청병안산전안매(ALT)、천동안산전안매(AST)、혈청총담홍소、백단백、백단백/구단백비치적변화.결과 경과3개월적치료후,2조환자균유일정적림상료효,관찰조환자적림상유효솔위81.8％ (27/33),명현고우대조조적60.0％ (18/30),차이유통계학의의(P＜0.05);2조환자치료후ALT、AST화총담홍소균교치료전명현하강,백단백、백단백/구단백비치균교치료전상승,차이유통계학의의(P ＜0.05혹P＜0.01),차치료후관찰조환자적이상지표변화여대조조비교,차이균유통계학의의[ALT:(31±8)U/L비(44±11)U/L、AST:(29 ±9) U/L비(43±11)U/L、총담홍소:(20±3)μmol/L비(25±3)μmol/L、백단백:(34.8±1.8)g/L비(32.9±1.8) g/L、백단백/구단백비치:(1.6±0.4)비(1.4±0.4)](P＜0.05혹P＜0.01).결론 익기해독연간법연합웅거양담산가이명현개선간공능,치료PBC유교호적림상료효.
Objective To explore the effect of Yiqijieduruangan method combined with ursodeoxycholic acid on treatment of primary biliary cirrhosis (PBC).Methods Totall 63 PBC patients in Affiliated Hospital of Chengde Medical College from October 2009 to June 2014 were randomly divided into observation group (33 cases) and control group (30 cases).Both the two groups were administrated with symptomatic treatment and ursodeoxycholic acid (250 mg,2 times/d),and the patients in observation group were additionally administrated with Yiqijieduruanganshuijianji method (one dose of Chinese medicine decoction per day,400 ml divided into 2 times,morning and night).Alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin albumin,albumin and albumin/globulin in blood serum were detected before and three months after treatment and compared between the two groups.Results Three months after treatment,clinical curative effects were observed in both the two groups.The efficiency of observation group was significantly higher than that of control group [81.8％ (27/33) vs 60％ (18/30),P ＜ 0.05].In both groups,ALT,AST and total bilirubin after treatment were significantly decreased,albumin and albumin/globulin were significantly increased compared with pretreatment with statistical differences (P ＜0.05 or P ＜0.01).Significant differences of above indices after treatment between observation group and control group were observed [ALT:(31 ± 8)U/L vs (44 ± 11)U/L,AST:(29 ± 9) U/L vs (43 ± 11) U/L,total bilirubin:(20 ± 3) μmol/L vs (25 ± 3) μmol/L,albumin:(34.8 ± 1.8)g/Lvs (32.9±1.8)g/L,albumin/globulin:(1.6±0.4) vs (1.4±0.4)] (P＜0.05 orP＜0.01).Conclusion Yiqijieduruanganshuijianji method combined with ursodeoxycholic acid can effectively improve the liver function,with preferable effect on treatment of PBC.
