中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
1期
13-17
,共5页
肝肿瘤%肝动脉化疗栓塞术%疼痛%盐酸羟考酮
肝腫瘤%肝動脈化療栓塞術%疼痛%鹽痠羥攷酮
간종류%간동맥화료전새술%동통%염산간고동
Liver neoplasms%Transcatheter arterial chemoembolization%Pain%Oxycodone hydrochloride
目的 观察肝肿瘤患者肝动脉化疗栓塞术后应用不同镇痛药物的镇痛效果及不良反应.方法 将98例肝肿瘤介入栓塞术后肝区中度以上疼痛患者按随机数字表法分为A、B、C组.其中A组33例,口服盐酸羟考酮缓释片镇痛;B组27例,外贴芬太尼透皮贴镇痛;C组38例,口服氨酚双氢可待因片镇痛.各组均临时应用吗啡针剂治疗爆发痛.镇痛达标后观察平均镇痛起效时间、平均镇痛达标时间、单药疼痛缓解率、观察时间内吗啡用量以及不良反应情况.结果 A、B、C组平均镇痛起效时间分别为(62±25)、(531 ±227)、(41±20) min;平均镇痛达标时间分别为(38±14)、(49±15)、(28 ±6)h,3组两两比较差异有统计学意义(P＜0.05).3组单药疼痛缓解率分别为A组100.0％(33/33)、B组66.7％ (18/27)、C组86.8％(33/38),解救吗啡用量A组(6±5)mg、B组(13 ±7)mg、C组(11 ±9)mg,A组与其他2组比较,差异有统计学意义(P＜0.05).A、B组与C组不良反应、便秘、嗜睡比较,差异有统计学意义[66.7％(22/33)、37.0％(10/27)比5.3％(2/38)和9.1％ (3/33)、25.9％(7/27)比0,P＜0.05].结论 盐酸羟考酮缓释片治疗肝肿瘤介入栓塞术后肝区疼痛作用稳定,不良反应少,效果较为理想.
目的 觀察肝腫瘤患者肝動脈化療栓塞術後應用不同鎮痛藥物的鎮痛效果及不良反應.方法 將98例肝腫瘤介入栓塞術後肝區中度以上疼痛患者按隨機數字錶法分為A、B、C組.其中A組33例,口服鹽痠羥攷酮緩釋片鎮痛;B組27例,外貼芬太尼透皮貼鎮痛;C組38例,口服氨酚雙氫可待因片鎮痛.各組均臨時應用嗎啡針劑治療爆髮痛.鎮痛達標後觀察平均鎮痛起效時間、平均鎮痛達標時間、單藥疼痛緩解率、觀察時間內嗎啡用量以及不良反應情況.結果 A、B、C組平均鎮痛起效時間分彆為(62±25)、(531 ±227)、(41±20) min;平均鎮痛達標時間分彆為(38±14)、(49±15)、(28 ±6)h,3組兩兩比較差異有統計學意義(P＜0.05).3組單藥疼痛緩解率分彆為A組100.0％(33/33)、B組66.7％ (18/27)、C組86.8％(33/38),解救嗎啡用量A組(6±5)mg、B組(13 ±7)mg、C組(11 ±9)mg,A組與其他2組比較,差異有統計學意義(P＜0.05).A、B組與C組不良反應、便祕、嗜睡比較,差異有統計學意義[66.7％(22/33)、37.0％(10/27)比5.3％(2/38)和9.1％ (3/33)、25.9％(7/27)比0,P＜0.05].結論 鹽痠羥攷酮緩釋片治療肝腫瘤介入栓塞術後肝區疼痛作用穩定,不良反應少,效果較為理想.
목적 관찰간종류환자간동맥화료전새술후응용불동진통약물적진통효과급불량반응.방법 장98례간종류개입전새술후간구중도이상동통환자안수궤수자표법분위A、B、C조.기중A조33례,구복염산간고동완석편진통;B조27례,외첩분태니투피첩진통;C조38례,구복안분쌍경가대인편진통.각조균림시응용마배침제치료폭발통.진통체표후관찰평균진통기효시간、평균진통체표시간、단약동통완해솔、관찰시간내마배용량이급불량반응정황.결과 A、B、C조평균진통기효시간분별위(62±25)、(531 ±227)、(41±20) min;평균진통체표시간분별위(38±14)、(49±15)、(28 ±6)h,3조량량비교차이유통계학의의(P＜0.05).3조단약동통완해솔분별위A조100.0％(33/33)、B조66.7％ (18/27)、C조86.8％(33/38),해구마배용량A조(6±5)mg、B조(13 ±7)mg、C조(11 ±9)mg,A조여기타2조비교,차이유통계학의의(P＜0.05).A、B조여C조불량반응、편비、기수비교,차이유통계학의의[66.7％(22/33)、37.0％(10/27)비5.3％(2/38)화9.1％ (3/33)、25.9％(7/27)비0,P＜0.05].결론 염산간고동완석편치료간종류개입전새술후간구동통작용은정,불량반응소,효과교위이상.
Objective To evaluate the efficacy and main side effects of different analgesics in patients with liver tumors after transcather arterial chemoembolization.Methods A total of 98 patients with moderate pain of liver after embolization were randomly divided into group A,group B and group C.Patients in group A (n =33) were treated with oxycodone hydrochloride controlled-release tablets,while the patients in group B (n =27) received fentanyl transdermal,group C(n =38) accepted paracetamol and dihydrocodeine tablets.In the addition,morphine injections were used to deal with the outbreak of pain during this research.The observation indexes were recorded,including the mean time for onset,up-to-standard of analgesic effect,rate of pain relief with single drug,the average dosage of morphine and side effect.Results The mean time of onset of analgesic effects was (62 ± 25) minutes (group A),(531 ± 227) minutes (group B) and (41 ± 20)minutes (group C) respectively; the mean time ofmeeting analgesic standards was (38 ± 14) hours (group A),(49 ± 15) hours (group B) and (28 ± 6) hours (group C) ; there were significant differences among three groups (P ＜ 0.01).The pain relief rate with single drug was 100.0％ (33/33) (group A),66.7％ (18/27) (group B) and 86.8％ (33/38) (group C) ; meanwhile in each group it was (6 ±5)mg (group A),(13 ±7)mg (group B) and (11 ±9)mg (group C) morphine injection.The incidences of adverse reactions including constipation and drowsiness were significantly different among group A,B and C.[66.7％ (22/33),37.0％ (10/27) vs 5.3％ (2/38) ; 9.1％ (3/33),75.9％ (7/27) vs 0.0％,P ＜ 0.05] Conclusion Oxycodone hydrochloride tablets is effective for liver tumors after embolization.
