中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2015年
1期
71-77
,共7页
血脂异常%患病率%Meta分析
血脂異常%患病率%Meta分析
혈지이상%환병솔%Meta분석
Dyslipidemia%Prevalence rate%Meta-analysis
目的 通过Meta分析了解中国儿童青少年血脂异常患病情况.方法 系统检索1974-2014年中国全文数据总库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)中有关中国儿童血脂异常调查的横断面研究中文文献,检索1946-2014年PubMed数据库中研究现场为中国的外文文献.通过STROBE声明进行文献质量评价,利用Stata 11.0软件估计血脂异常的Meta合并患病率,并对三间分布及时间变化趋势执行亚组分析,采用敏感性分析评价文献质量和不同诊断标准对结果的影响.结果 共纳入24篇文献,总样本量为129 426人,中国儿童青少年合并血脂异常总患病率为25.3％(95％CI:12.7％～37.8％).高TC、高LDL-C、高TG、低HDL-C、高脂血症等血脂异常患病率分别为4.1％(95％a:3.4％～4.9％)、5.3％(95％CI:3.9％～6.7％)、8.5％(95％CI:6.3％ ～ 10.7％)、6.8％(95％CI:3.7％～9.9％)、4.8％(95％CI:0.6％～9.1％).男童高TG患病率(5.6％)高于女童(3.4％),高TC、高LDL-C、低HDL-C、高脂血症及血脂异常总患病率男童均低于女童,差异均有统计学意义(P＜0.05).7～18岁儿童青少年血脂异常总患病率(31.6％)高于2～6岁儿童(9.0％),差异有统计学意义(P＜0.05).高TG、高TC及低HDL-C患病率在不同年龄段、地区、时期差异均无统计学意义.结论 中国儿童青少年血脂异常患病率较高,应适时进行血脂筛查,及早发现异常并实施干预.
目的 通過Meta分析瞭解中國兒童青少年血脂異常患病情況.方法 繫統檢索1974-2014年中國全文數據總庫(CNKI)、萬方數據庫、中國生物醫學文獻數據庫(CBM)中有關中國兒童血脂異常調查的橫斷麵研究中文文獻,檢索1946-2014年PubMed數據庫中研究現場為中國的外文文獻.通過STROBE聲明進行文獻質量評價,利用Stata 11.0軟件估計血脂異常的Meta閤併患病率,併對三間分佈及時間變化趨勢執行亞組分析,採用敏感性分析評價文獻質量和不同診斷標準對結果的影響.結果 共納入24篇文獻,總樣本量為129 426人,中國兒童青少年閤併血脂異常總患病率為25.3％(95％CI:12.7％～37.8％).高TC、高LDL-C、高TG、低HDL-C、高脂血癥等血脂異常患病率分彆為4.1％(95％a:3.4％～4.9％)、5.3％(95％CI:3.9％～6.7％)、8.5％(95％CI:6.3％ ～ 10.7％)、6.8％(95％CI:3.7％～9.9％)、4.8％(95％CI:0.6％～9.1％).男童高TG患病率(5.6％)高于女童(3.4％),高TC、高LDL-C、低HDL-C、高脂血癥及血脂異常總患病率男童均低于女童,差異均有統計學意義(P＜0.05).7～18歲兒童青少年血脂異常總患病率(31.6％)高于2～6歲兒童(9.0％),差異有統計學意義(P＜0.05).高TG、高TC及低HDL-C患病率在不同年齡段、地區、時期差異均無統計學意義.結論 中國兒童青少年血脂異常患病率較高,應適時進行血脂篩查,及早髮現異常併實施榦預.
목적 통과Meta분석료해중국인동청소년혈지이상환병정황.방법 계통검색1974-2014년중국전문수거총고(CNKI)、만방수거고、중국생물의학문헌수거고(CBM)중유관중국인동혈지이상조사적횡단면연구중문문헌,검색1946-2014년PubMed수거고중연구현장위중국적외문문헌.통과STROBE성명진행문헌질량평개,이용Stata 11.0연건고계혈지이상적Meta합병환병솔,병대삼간분포급시간변화추세집행아조분석,채용민감성분석평개문헌질량화불동진단표준대결과적영향.결과 공납입24편문헌,총양본량위129 426인,중국인동청소년합병혈지이상총환병솔위25.3％(95％CI:12.7％～37.8％).고TC、고LDL-C、고TG、저HDL-C、고지혈증등혈지이상환병솔분별위4.1％(95％a:3.4％～4.9％)、5.3％(95％CI:3.9％～6.7％)、8.5％(95％CI:6.3％ ～ 10.7％)、6.8％(95％CI:3.7％～9.9％)、4.8％(95％CI:0.6％～9.1％).남동고TG환병솔(5.6％)고우녀동(3.4％),고TC、고LDL-C、저HDL-C、고지혈증급혈지이상총환병솔남동균저우녀동,차이균유통계학의의(P＜0.05).7～18세인동청소년혈지이상총환병솔(31.6％)고우2～6세인동(9.0％),차이유통계학의의(P＜0.05).고TG、고TC급저HDL-C환병솔재불동년령단、지구、시기차이균무통계학의의.결론 중국인동청소년혈지이상환병솔교고,응괄시진행혈지사사,급조발현이상병실시간예.
Objective To quantify the prevalence of dyslipidemia among children and adolescents in China.Methods Chinese Biomedical Database (CBM),Wanfang Databases,China National Knowledge Infrastructme (CNKI) and PubMed were comprehensively searched.Original reports were selected if data on prevalence estimates of dyslipdemia among children and adolescents in China,was provided under cross-sectional epidemiological studies.Quality of the literature was evaluated through the STROBE statement.The prevalence through Meta was estimated using the Strata 11.0 software.Subgroup analysis was undertaken on gender,age,regions and secular trends issues.Sensitivity analysis was performed to evaluate the impact of quality or standard of diagnosis.Results A total of 24 papers were included in this Meta-analysis,with the whole sample size as 129 426.The overall pooled-prevalence of total dsylipidemia was estimated at 25.3％ (95％ CI:12.7％-37.8％).Prevalence rates of high TC,LDL-C,TG,low HDL-C and hyperlipemia were 4.1％ (95％ CI:3.4％-4.9％),5.3％ (95％ CI:3.9％-6.7％),8.5％ (95％ CI:6.3％-10.7％),6.8％ (95％ CI:3.7％-9.9％),4.8％ (95％CI:0.6％-9.1％),respectively.Girls (3.4％) had lower prevalence of high TG than boys (5.6％),but having higher prevalence of other different types dyslipidemia.Children aged 7-18 years had higher overall prevalence of dyslipidemia (31.6％)when compared to children aged 2-6 years (9.0％).There were no statistically significant differences for subgroups of age,region and period regarding the prevalence rates of high TG,TC and low HDL-C (P＞0.05).Conclusion Prevalence of dyslipidemia was high and with increasing trend among children and adolescents in China.Early screening and prevention programs on abnormal serum lipids should be emphasized and promoted.
