中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2015年
2期
118-121
,共4页
谢静%邱志峰%韩扬%李雁凌%宋晓璟%李太生
謝靜%邱誌峰%韓颺%李雁凌%宋曉璟%李太生
사정%구지봉%한양%리안릉%송효경%리태생
HIV%获得性免疫缺陷综合征%CD4+ T细胞%淋巴细胞计数
HIV%穫得性免疫缺陷綜閤徵%CD4+ T細胞%淋巴細胞計數
HIV%획득성면역결함종합정%CD4+ T세포%림파세포계수
HIV%Acquired immunodeficiency syndrome%CD4+ T cell%Lymphocyte count
目的 对淋巴细胞计数预测CD4+ T细胞计数的准确性进行评价,为临床应用提供支持.方法 在全国23个分中心共筛查2 013例未接受抗病毒治疗的HIV/AIDS患者,经流式细胞术检测CD4+ T细胞计数,分析血常规当中的淋巴细胞计数和CD4+ T细胞计数之间的相关性,绘制ROC曲线判断淋巴细胞计数预测CD4+T细胞计数的准确性,并计算其敏感度、特异度、阳性预测值和阴性预测值.结果 2 013例HIV/AIDS患者的淋巴细胞计数和CD4+ T细胞计数分别为(1 600±670)×106/L和(244±148)×106/L,两者呈现显著正相关性(r=0.482,P＜0.000 1),以淋巴细胞计数预测CD4T细胞计数＜100×106/L、＜200×106/L和＜350×106/L的AUCROC分别为0.790(95％ CI0.761 ～0.818,P＜0.000 1),0.733(95％ CI0.710 ～0.755,P ＜0.000 1)和0.732 (95％ CI0.706 ～0.758,P ＜0.000 1).结论 在HIV/AIDS患者的临床诊治中,用淋巴细胞计数预测CD4+ T细胞计数有其实用价值,可以考虑在不具备CD4+ T细胞计数直接检测时作为替代指标用于监测疾病进展,也可以在获得CD4+ T细胞计数结果之前用来初步快速判断患者病情.
目的 對淋巴細胞計數預測CD4+ T細胞計數的準確性進行評價,為臨床應用提供支持.方法 在全國23箇分中心共篩查2 013例未接受抗病毒治療的HIV/AIDS患者,經流式細胞術檢測CD4+ T細胞計數,分析血常規噹中的淋巴細胞計數和CD4+ T細胞計數之間的相關性,繪製ROC麯線判斷淋巴細胞計數預測CD4+T細胞計數的準確性,併計算其敏感度、特異度、暘性預測值和陰性預測值.結果 2 013例HIV/AIDS患者的淋巴細胞計數和CD4+ T細胞計數分彆為(1 600±670)×106/L和(244±148)×106/L,兩者呈現顯著正相關性(r=0.482,P＜0.000 1),以淋巴細胞計數預測CD4T細胞計數＜100×106/L、＜200×106/L和＜350×106/L的AUCROC分彆為0.790(95％ CI0.761 ～0.818,P＜0.000 1),0.733(95％ CI0.710 ～0.755,P ＜0.000 1)和0.732 (95％ CI0.706 ～0.758,P ＜0.000 1).結論 在HIV/AIDS患者的臨床診治中,用淋巴細胞計數預測CD4+ T細胞計數有其實用價值,可以攷慮在不具備CD4+ T細胞計數直接檢測時作為替代指標用于鑑測疾病進展,也可以在穫得CD4+ T細胞計數結果之前用來初步快速判斷患者病情.
목적 대림파세포계수예측CD4+ T세포계수적준학성진행평개,위림상응용제공지지.방법 재전국23개분중심공사사2 013례미접수항병독치료적HIV/AIDS환자,경류식세포술검측CD4+ T세포계수,분석혈상규당중적림파세포계수화CD4+ T세포계수지간적상관성,회제ROC곡선판단림파세포계수예측CD4+T세포계수적준학성,병계산기민감도、특이도、양성예측치화음성예측치.결과 2 013례HIV/AIDS환자적림파세포계수화CD4+ T세포계수분별위(1 600±670)×106/L화(244±148)×106/L,량자정현현저정상관성(r=0.482,P＜0.000 1),이림파세포계수예측CD4T세포계수＜100×106/L、＜200×106/L화＜350×106/L적AUCROC분별위0.790(95％ CI0.761 ～0.818,P＜0.000 1),0.733(95％ CI0.710 ～0.755,P ＜0.000 1)화0.732 (95％ CI0.706 ～0.758,P ＜0.000 1).결론 재HIV/AIDS환자적림상진치중,용림파세포계수예측CD4+ T세포계수유기실용개치,가이고필재불구비CD4+ T세포계수직접검측시작위체대지표용우감측질병진전,야가이재획득CD4+ T세포계수결과지전용래초보쾌속판단환자병정.
Objective To evaluate the accuracy of lymphocyte count as a surrogate for CD4+T cell count in treatment-na(i)ve HIV-infected adults.Methods A total of 2 013 HIV-infected patients were screened at 23 sites in China.CD4+ T cell counts were measured by flow cytometry.Correlation between CD4+ T cell count and peripheral lymphocyte count were analyzed by spearman coefficient.AUCRoc were used to evaluate the performance of lymphocyte count as a surrogate for CD4+ T cell count.Results The lymphocyte count and CD4+T cell count of these 2 013 patients were (1 600±670) × 106/L and (244 ± 148) × 106/L respectively.CDa+ T cell count were positively correlated with lymphocyte count(r =0.482,P ＜0.000 1).AUCROC of lymphocyte count as a surrogate for CD4+ T cell counts of ＜ 100 × 106/L,＜200 × 106/L and ＜ 350 × 106/L were 0.790 (95％ CI 0.761-0.818,P ＜ 0.000 1),0.733 (95％ CI 0.710-0.755,P ＜ 0.000 1) and 0.732 (95％ CI 0.706-0.758,P ＜ 0.000 1) respectively.Conclusion Lymphocyte count could be considerad as a potential surrogate marker for CD4+ T cell count in HIV/AIDS patients not having access to T cell subset test by flowcytometry.
